Cited by 474Microtubule and mitosis dynamicsProtein Structure and DynamicsCellular Mechanics and Interactions

The design plan of kinesin motors

Vale, Ronald D., Fletterick, Robert J.·1997·Annual Review of Cell and Developmental Biology

Abstract

The kinesin superfamily comprises a large and structurally diverse group of microtubule-based motor proteins that produce a variety of force-generating activities within cells. This review addresses how the structures of kinesin proteins provide clues as to their biological functions and motile properties. We discuss structural features common to all kinesin motors, as well as specialized features that enable subfamilies of related motors to carry out specialized activities. We also discuss how the kinesin motor domain uses chemical energy from ATP hydrolysis to move along microtubules.

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Crossref · 10.1146/annurev.cellbio.13.1.745

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109 of 109 references verified0 citation errors · 0 not checkable

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  • Bending of the stalk domain of HC is likely due to helix-disrupting residues in the hinge region.

    “Bending of the stalk domain of HC is likely due to helix-disrupting residues in the hinge region (Vale and Fletterick, 1997).”

    From Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules (1998) · cites this paper as Vale and Fletterick, 1997

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Authors
Vale, R. D., & Fletterick, R. J.
Affiliations
Howard Hughes Medical Institute (US)
Venue
Annual Review of Cell and Developmental Biology
Published
1997-11
Volume
13
Issue
1
Pages
745-777
ISSN
  • 1081-0706 (ISSN-L)
  • 1530-8995
OpenAlex
W1985709969
Cited by
474
References
109
Citations by year
2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 13 · 2015: 11 · 2014: 8 · 2013: 16 · 2012: 15
FWCI
2.98
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Cell and Developmental Biology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords
kinesin, kinesin superfamily, microtubule motor proteins, ATP hydrolysis, microtubule sliding, protein structure-function relationship
MeSH terms
Adenosine Triphosphate, Amino Acid Sequence, Animals, Energy Metabolism, Humans, Molecular Sequence Data, Protein Conformation, Kinesins, Macromolecular Substances

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