The design plan of kinesin motors
Abstract
The kinesin superfamily comprises a large and structurally diverse group of microtubule-based motor proteins that produce a variety of force-generating activities within cells. This review addresses how the structures of kinesin proteins provide clues as to their biological functions and motile properties. We discuss structural features common to all kinesin motors, as well as specialized features that enable subfamilies of related motors to carry out specialized activities. We also discuss how the kinesin motor domain uses chemical energy from ATP hydrolysis to move along microtubules.
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Bending of the stalk domain of HC is likely due to helix-disrupting residues in the hinge region.
“Bending of the stalk domain of HC is likely due to helix-disrupting residues in the hinge region (Vale and Fletterick, 1997).”
From Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules (1998) · cites this paper as Vale and Fletterick, 1997
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The Molecular Motor Toolbox for Intracellular Transport
Vale, R. D. (2003) · Cell · doi:10.1016/s0092-8674(03)00111-9 · Cited by 1,982 · see citing works
Self-citationYildiz, A., Tomishige, M., Vale, R. D., & Selvin, P. R. (2004) · Science · doi:10.1126/science.1093753 · Cited by 965 · see citing works
Self-citationA structural change in the kinesin motor protein that drives motility
Rice, S., Lin, A. W., Safer, D., Hart, C. L., Naber, N., Carragher, B. O., Cain, S. M., Pechatnikova, E., Wilson-Kubalek, E. M., Whittaker, M., et al. (1999) · Nature · doi:10.1038/45483 · Cited by 798 · see citing works
Self-citationKin I kinesins are microtubule-destabilizing enzymes
Desai, A., Verma, S., Mitchison, T. J., & Walczak, C. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80960-5 · Cited by 708 · see citing works
Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules
Verhey, K. J., Meyer, D., Deehan, R., Blenis, J., Schnapp, B. J., Rapoport, T. A., & Margolis, B. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.5.959 · Cited by 609 · see citing works
Kinesin Moves by an Asymmetric Hand-Over-Hand Mechanism
Asbury, C. L., Fehr, A. N., & Block, S. M. (2003) · Science · doi:10.1126/science.1092985 · Cited by 511 · see citing works
Microtubule interaction site of the kinesin motor
Woehlke, G., Ruby, A. K., Hart, C. L., Ly, B., Hom-Booher, N., & Vale, R. D. (1997) · Cell · doi:10.1016/s0092-8674(00)80329-3 · Cited by 386 · see citing works
Self-citationMartin, M., Iyadurai, S. J., Gassman, A., Gindhart, J. G., Hays, T. S., & Saxton, W. M. (1999) · Molecular Biology of the Cell · doi:10.1091/mbc.10.11.3717 · Cited by 365 · see citing works
Light Chain– dependent Regulation of Kinesin's Interaction with Microtubules
Verhey, K. J., Lizotte, D. L., Abramson, T., Barenboim, L., Schnapp, B. J., & Rapoport, T. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1053 · Cited by 266 · see citing works
“Bending of the stalk domain of HC is likely due to helix-disrupting residues in the hinge region (Vale and Fletterick, 1997).”
BackgroundDeterminants of Kinesin Motor Polarity
Endow, S. A., & Waligora, K. W. (1998) · Science · doi:10.1126/science.281.5380.1200 · Cited by 176 · see citing works
Kinesin Light Chains Are Essential for Axonal Transport in <i>Drosophila </i>
Gindhart, J. G., Desai, C. J., Beushausen, S., Zinn, K., & Goldstein, L. S. B. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.2.443 · Cited by 179 · see citing works
Mennella, V., Rogers, G. C., Rogers, S. L., Buster, D. W., Vale, R. D., & Sharp, D. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1222 · Cited by 154 · see citing works
Self-citationCargo binding and regulatory sites in the tail of fungal conventional kinesin
Seiler, S., Kirchner, J., Horn, C., Kallipolitou, A., Woehlke, G., & Schliwa, M. (2000) · Nature Cell Biology · doi:10.1038/35014022 · Cited by 147 · see citing works
Microtubule-depolymerizing kinesins
Wordeman, L. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.12.003 · Cited by 114 · see citing works
Lucky 13-microtubule depolymerisation by kinesin-13 motors
Moores, C. A., & Milligan, R. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.03224 · Cited by 92 · see citing works
Protein complexes at the microtubule organizing center regulate bipolar spindle assembly
Rodriguez, A. S., Killilea, A. N., Batac, J., Filopei, J., Simeonov, D., Lin, I., & Paluh, J. L. (2008) · Cell Cycle · doi:10.4161/cc.7.9.5808 · Cited by 38 · see citing works
Gutiérrez-Medina, B., Fehr, A. N., & Block, S. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907133106 · Cited by 37 · see citing works
Coordination between Motor Domains in Processive Kinesins
Sablin, E. P., & Fletterick, R. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r300036200 · Cited by 32 · see citing works
Self-citationProteome and cytoskeleton responses in osteosarcoma cells with reduced OXPHOS activity
Annunen‐Rasila, J., Ohlmeier, S., Tuokko, H., Veijola, J., & Majamaa, K. (2007) · PROTEOMICS · doi:10.1002/pmic.200601031 · Cited by 31 · see citing works
- Authors
- Vale, R. D., & Fletterick, R. J.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 1997-11
- Volume
- 13
- Issue
- 1
- Pages
- 745-777
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W1985709969
- Cited by
- 474
- References
- 109
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 3 · 2016: 13 · 2015: 11 · 2014: 8 · 2013: 16 · 2012: 15
- FWCI
- 2.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- kinesin, kinesin superfamily, microtubule motor proteins, ATP hydrolysis, microtubule sliding, protein structure-function relationship
- MeSH terms
- Adenosine Triphosphate, Amino Acid Sequence, Animals, Energy Metabolism, Humans, Molecular Sequence Data, Protein Conformation, Kinesins, Macromolecular Substances
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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