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Control of Drosophila body pattern by the hunchback morphogen gradient
Open accessAbstract
Most of the thoracic and abdominal segments of Drosophila are specified early in embryogenesis by the overlapping activities of the hunchback (hb), Krüppel, knirps, and giant gap genes. The orderly expression of these genes depends on two maternal determinants: bicoid, which activates hb transcription anteriorly, and nanos, which blocks translation of hb transcripts posteriorly. Here we provide evidence that the resulting gradient of hb protein dictates where the Krüppel, knirps, and giant genes are expressed by providing a series of concentration thresholds that regulate each gene independently. Thus, hb protein functions as a classical morphogen, triggering several distinct responses as a function of its graded distribution.
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Cites
The chemical basis of morphogenesis
Turing, A. M. (1952) · Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences · doi:10.1098/rstb.1952.0012 · Cited by 11,733
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Metadata
- Authors
- Struhl, G., Johnston, P., & Lawrence, P. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1992-04
- Volume
- 69
- Issue
- 2
- Pages
- 237-249
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2121040242
- Cited by
- 283
- References
- 1
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Struhl, G., Johnston, P., & Lawrence, P. A. (1992). Control of Drosophila body pattern by the hunchback morphogen gradient. Cell. https://doi.org/10.1016/0092-8674(92)90405-2
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
