The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structurally distinct and stage-specific adenylyl cyclase genes play different roles in dictyostelium development
Open accessAbstract
We have isolated two adenylyl cyclase genes, designated ACA and ACG, from Dictyostelium. The proposed structure for ACA resembles that proposed for mammalian adenylyl cyclases: two large hydrophilic domains and two sets of six transmembrane spans. ACG has a novel structure, reminiscent of the membrane-bound guanylyl cyclases. An aca- mutant, created by gene disruption, has little detectable adenylyl cyclase activity and fails to aggregate, demonstrating that cAMP is required for cell-cell communication. cAMP is not required for motility, chemotaxis, growth, and cell division, which are unaffected. Constitutive expression in aca- cells of either ACA or ACG, which is normally expressed only during germination, restores aggregation and the ability to complete the developmental program. ACA expression restores receptor and guanine nucleotide-regulated adenylyl cyclase activity, while activity in cells expressing ACG is insensitive to these regulators. Although they lack ACA, which has a transporter-like structure, the cells expressing ACG secrete cAMP constitutively.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits
Tang, W.-J., & Gilman, A. G. (1991) · Science · doi:10.1126/science.1962211 · Cited by 1,091
The Drosophila learning and memory gene rutabaga encodes a - adenylyl cyclase
Levin, L. R., Han, P.-L., Hwang, P. M., Feinstein, P. G., Davis, R. L., & Reed, R. R. (1992) · Cell · doi:10.1016/0092-8674(92)90185-f · Cited by 517
Self-citation
Cited by
Mammalian Membrane-bound Adenylyl Cyclases
Taussig, R., & Gilman, A. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.1 · Cited by 721
Tumor Suppressor PTEN Mediates Sensing of Chemoattractant Gradients
Iijima, M., & Devreotes, P. (2002) · Cell · doi:10.1016/s0092-8674(02)00745-6 · Cited by 677
Self-citationSwaney, K. F., Huang, C.-H., & Devreotes, P. N. (2010) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.093008.131228 · Cited by 494
Self-citationOrganization and Ca2+Regulation of Adenylyl Cyclases in cAMP Microdomains
Willoughby, D., & Cooper, D. M. F. (2007) · Physiological Reviews · doi:10.1152/physrev.00049.2006 · Cited by 451
Loovers, H. M., Postma, M., Keizer-Gunnink, I., Huang, Y. E., Devreotes, P. N., & van Haastert, P. J. M. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-09-0825 · Cited by 104
Self-citation
Metadata
- Authors
- Pitt, G. S., Milona, N., Borleis, J., Lin, K. C., Reed, R. R., & Devreotes, P. N.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1992-04
- Volume
- 69
- Issue
- 2
- Pages
- 305-315
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2158040291
- Cited by
- 311
- References
- 3
- FWCI
- 26.63
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Structurally distinct and stage-specific adenylyl cyclase genes play different roles in dictyostelium development. https://app.cochat.ai/papers/10.1016/0092-8674(92)90411-5
- The paper
- Pitt, G. S., Milona, N., Borleis, J., Lin, K. C., Reed, R. R., & Devreotes, P. N. (1992). Structurally distinct and stage-specific adenylyl cyclase genes play different roles in dictyostelium development. Cell. https://doi.org/10.1016/0092-8674(92)90411-5
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
