The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
Open accessAbstract
In transgenic mice, self-reactive B lymphocytes are eliminated if they encounter membrane-bound self antigens during their development within the bone marrow. We show here that two separate and sequential events, arrested development and cell death, bring about B cell elimination. Developmental arrest is an early outcome of antigen binding in immature B cells, blocks acquisition of adhesion molecules and receptors important for B cell migration and activation, and is rapidly reversible by removal of antigen. Death of the arrested B cells occurs within 1 to 3 days and can be delayed by expression of a bcl-2 transgene, which results in escape of large numbers of self-reactive B cells from the bone marrow but fails to override the developmental arrest. These findings define a novel pathway for B cell elimination, involving an initial stage vulnerable to breakdown in autoimmune disease.
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Cites
McDonnell, T. J., Deane, N., Platt, F. M., Nunez, G., Jaeger, U., McKearn, J. P., & Korsmeyer, S. J. (1989) · Cell · doi:10.1016/0092-8674(89)90174-8 · Cited by 1,213
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Cited by
Hardy, R. R., & Hayakawa, K. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.595 · Cited by 1,235
The many roles of FAS receptor signaling in the immune system
Strasser, A., Jost, P. J., & Nagata, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.001 · Cited by 968
Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.
Strasser, A., Harris, A. W., Huang, D. C., Krammer, P. H., & Cory, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00304.x · Cited by 784
Self-citationNegative selection of lymphocytes
Nossal, G. J. V. (1994) · Cell · doi:10.1016/0092-8674(94)90331-x · Cited by 785
Thien, M., Phan, T. G., Gardam, S., Amesbury, M., Basten, A., Mackay, F., & Brink, R. (2004) · Immunity · doi:10.1016/j.immuni.2004.05.010 · Cited by 746
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Metadata
- Authors
- Hartley, S. B., Cooke, M. P., Fulcher, D. A., Harris, A. W., Cory, S., Basten, A., & Goodnow, C. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-02
- Volume
- 72
- Issue
- 3
- Pages
- 325-335
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2052438035
- Cited by
- 509
- References
- 2
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hartley, S. B., Cooke, M. P., Fulcher, D. A., Harris, A. W., Cory, S., Basten, A., & Goodnow, C. C. (1993). Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death. Cell. https://doi.org/10.1016/0092-8674(93)90111-3
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