The many roles of FAS receptor signaling in the immune system

Death Receptors: Signaling and Modulation

Ashkenazi, A., & Dixit, V. M. (1998) · Science · doi:10.1126/science.281.5381.1305 · Cited by 5,866 · see citing works

Apoptosis by Death Factor

Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,908 · see citing works

The BCL-2 protein family: opposing activities that mediate cell death

Youle, R. J., & Strasser, A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2308 · Cited by 4,704 · see citing works

Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Li, H., Zhu, H., Xu, C.-J., & Yuan, J. (1998) · Cell · doi:10.1016/s0092-8674(00)81590-1 · Cited by 4,445 · see citing works

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

Luo, X., Budihardjo, I., Zou, H., Slaughter, C., & Wang, X. (1998) · Cell · doi:10.1016/s0092-8674(00)81589-5 · Cited by 3,626 · see citing works

The Pathophysiology of Mitochondrial Cell Death

Green, D. R., & Kroemer, G. (2004) · Science · doi:10.1126/science.1099320 · Cited by 3,416 · see citing works

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., & Nagata, S. (1998) · Nature · doi:10.1038/34112 · Cited by 3,181 · see citing works

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Watanabe‐Fukunaga, R., Brannan, C., Copeland, N., Jenkins, N., & Nagata, S. (1992) · Nature · doi:10.1038/356314a0 · Cited by 3,153 · see citing works

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046 · see citing works

Two CD95 (APO‐1/Fas) signaling pathways

Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K., Krammer, P. H., & Peter, M. E. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1675 · Cited by 3,000 · see citing works

Signalling pathways of the TNF superfamily: a double-edged sword

Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793 · see citing works

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736 · see citing works

Inhibition of death receptor signals by cellular FLIP

Irmler, M., Thome, M., Hahne, M., Schneider, P., Hofmann, K., Steiner, V., Bodmer, J.-L., Schröter, M., Burns, K., Mattmann, C., et al. (1997) · Nature · doi:10.1038/40657 · Cited by 2,548 · see citing works

Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family

Suda, T., Takahashi, T., Golstein, P., & Nagata, S. (1993) · Cell · doi:10.1016/0092-8674(93)90326-l · Cited by 2,488 · see citing works

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431 · see citing works

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

Boldin, M. P., Goncharov, T. M., Goltseve, Y. V., & Wallach, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81265-9 · Cited by 2,292 · see citing works

Safety and antitumor activity of recombinant soluble Apo2 ligand

Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6926 · Cited by 2,213 · see citing works

Cytotoxicity‐dependent APO‐1 (Fas/CD95)‐associated proteins form a death‐inducing signaling complex (DISC) with the receptor.

Kischkel, F. C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P. H., & Peter, M. E. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00245.x · Cited by 2,181 · see citing works

Caspases: Intracellular Signaling by Proteolysis

Salvesen, G. S., & Dixit, V. M. (1997) · Cell · doi:10.1016/s0092-8674(00)80430-4 · Cited by 2,133 · see citing works

Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege

Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990 · see citing works

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

Smith, C. A., Farrah, T., & Goodwin, R. G. (1994) · Cell · doi:10.1016/0092-8674(94)90372-7 · Cited by 1,909 · see citing works

Lethal effect of the anti-Fas antibody in mice

Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881 · see citing works

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

Dhein, J., Walczak, H., Bäumler, C., Debatin, K., & Krammer, P. (1995) · Nature · doi:10.1038/373438a0 · Cited by 1,814 · see citing works

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

Trauth, B. C., Klas, C., Peters, A. M. J., Matzku, S., Mӧller, P., Falk, W., Debatin, K., & Krammer, P. H. (1989) · Science · doi:10.1126/science.2787530 · Cited by 1,716 · see citing works

CD95's deadly mission in the immune system

Krammer, P. H. (2000) · Nature · doi:10.1038/35037728 · Cited by 1,710 · see citing works

The immune response of Drosophila

Hoffmann, J. A. (2003) · Nature · doi:10.1038/nature02021 · Cited by 1,553 · see citing works

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

Takahashi, T., Tanaka, M., Brannan, C. I., Jenkins, N. A., Copeland, N. G., Suda, T., & Nagata, S. (1994) · Cell · doi:10.1016/0092-8674(94)90375-1 · Cited by 1,527 · see citing works

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

Kägi, D., Vignaux, F., Ledermann, B., Bürki, K., Depraetere, V., Nagata, S., Hengartner, H., & Golstein, P. (1994) · Science · doi:10.1126/science.7518614 · Cited by 1,513 · see citing works

Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome

Fisher, G. H., Rosenberg, F. J., Straus, S. E., Dale, J. K., Middelton, L. A., Lin, A. Y., Strober, W., Lenardo, M. J., & Puck, J. M. (1995) · Cell · doi:10.1016/0092-8674(95)90013-6 · Cited by 1,454 · see citing works

Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity.

Rieux-Laucat, F., Deist, F. L., Hivroz, C., Roberts, I., Debatin, K., Fischer, A., & de Villartay, J. (1995) · Science · doi:10.1126/science.7539157 · Cited by 1,405 · see citing works

A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor.

Yonehara, S., Ishii, A., & Yonehara, M. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1747 · Cited by 1,398 · see citing works

Apoptosis Signaling

Strasser, A., O’Connor, L., & Dixit, V. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.217 · Cited by 1,369 · see citing works

Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

Varfolomeev, E., Schuchmann, M., Luria, V., Chiannilkulchai, N., Beckmann, J., Mett, I., Rebrikov, D., Brodianski, V. M., Kemper, O., Kollet, O., et al. (1998) · Immunity · doi:10.1016/s1074-7613(00)80609-3 · Cited by 1,332 · see citing works

Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas

Brunner, T., Mogil, R. J., LaFace, D., Yoo, N. J., Mahboubi, A., Echeverri, F., Martin, S. J., Force, W. R., Lynch, D. H., Ware, C. F., et al. (1995) · Nature · doi:10.1038/373441a0 · Cited by 1,314 · see citing works

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Varfolomeev, E., Blankenship, J. W., Wayson, S. M., Fedorova, A. V., Kayagaki, N., Garg, P., Zobel, K., Dynek, J. N., Elliott, L. O., Wallweber, H. J. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.030 · Cited by 1,218 · see citing works

FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)

Medema, J. P., Scaffidi, C., Kischkel, F. C., Shevchenko, A., Mann, M., Krammer, P. H., & Peter, M. E. (1997) · The EMBO Journal · doi:10.1093/emboj/16.10.2794 · Cited by 1,189 · see citing works

Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease

Cohen, P. L., & Eisenberg, R. A. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001331 · Cited by 1,169 · see citing works

Bim: a novel member of the Bcl‐2 family that promotes apoptosis

O’Connor, L., Strasser, A., O’Reilly, L. A., Hausmann, G., Adams, J. M., Cory, S., & Huang, D. C. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.384 · Cited by 1,163 · see citing works

A role for CD95 ligand in preventing graft rejection

Bellgrau, D., Gold, D. P., Selawry, H. P., Moore, J. K., Franzusoff, A., & Duke, R. C. (1995) · Nature · doi:10.1038/377630a0 · Cited by 1,147 · see citing works

Structure of Bax

Suzuki, M., Youle, R. J., & Tjandra, N. (2000) · Cell · doi:10.1016/s0092-8674(00)00167-7 · Cited by 1,104 · see citing works

IAP Antagonists Target cIAP1 to Induce TNFα-Dependent Apoptosis

Vince, J. E., Wong, W. W.-L., Khan, N. R., Feltham, R., Chau, D., Ahmed, A. U., Benetatos, C. A., Chunduru, S. K., Condon, S. M., McKinlay, M. A., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.037 · Cited by 1,061 · see citing works

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

Strasser, A., Harris, A. W., & Cory, S. (1991) · Cell · doi:10.1016/0092-8674(91)90362-3 · Cited by 1,054 · see citing works

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

Lowin, B., Hahne, M., Mattmann, C., & Tschopp, J. (1994) · Nature · doi:10.1038/370650a0 · Cited by 1,052 · see citing works

BH3-Only Proteins—Essential Initiators of Apoptotic Cell Death

Huang, D. C. S., & Strasser, A. (2000) · Cell · doi:10.1016/s0092-8674(00)00187-2 · Cited by 1,044 · see citing works

Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

Yin, X.-M., Wang, K., Gross, A., Zhao, Y., Zinkel, S., Klocke, B., Roth, K. A., & Korsmeyer, S. J. (1999) · Nature · doi:10.1038/23730 · Cited by 1,004 · see citing works

A Novel Protein That Interacts with the Death Domain of Fas/APO1 Contains a Sequence Motif Related to the Death Domain

Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H., & Wallach, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.7795 · Cited by 993 · see citing works

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

Friesen, C., Herr, I., Krammer, P. H., & Debatin, K. (1996) · Nature Medicine · doi:10.1038/nm0596-574 · Cited by 975 · see citing works

A Unified Model for Apical Caspase Activation

Boatright, K. M., Renatus, M., Scott, F. L., Sperandio, S., Shin, H., Pedersen, I. M., Ricci, J., Edris, W. A., Sutherlin, D. P., Green, D. R., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00051-0 · Cited by 963 · see citing works

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

Parijs, L. V., & Abbas, A. K. (1998) · Science · doi:10.1126/science.280.5361.243 · Cited by 958 · see citing works

Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944 · see citing works

Fas ligand mediates activation-induced cell death in human T lymphocytes.

Alderson, M. R., Tough, T. W., Davis-Smyth, T., Braddy, S., Falk, B. A., Schooley, K., Goodwin, R. G., Smith, C. A., Ramsdell, F., & Lynch, D. H. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.71 · Cited by 933 · see citing works

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

Yeh, W., de la Pompa, J. L., McCurrach, M. E., Shu, H., Elia, A., Shahinian, A., Ng, M. S. W., Wakeham, A. C., Khoo, W., Mitchell, K., et al. (1998) · Science · doi:10.1126/science.279.5358.1954 · Cited by 886 · see citing works

Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.

Strasser, A., Whittingham, S., Vaux, D. L., Bath, M. L., Adams, J. M., Cory, S., & Harris, A. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8661 · Cited by 861 · see citing works

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

Schneider, P., Holler, N., Bodmer, J.-L., Hahne, M., Frei, K., Fontana, A., & Tschopp, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.8.1205 · Cited by 804 · see citing works

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

Zhang, J., Cado, D., Chen, A., Kabra, N., & Winoto, A. (1998) · Nature · doi:10.1038/32681 · Cited by 792 · see citing works

Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.

Strasser, A., Harris, A. W., Huang, D. C., Krammer, P. H., & Cory, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00304.x · Cited by 784 · see citing works

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

Bouillet, P., Purton, J. F., Godfrey, D. I., Zhang, L.-C., Coultas, L., Puthalakath, H., Pellegrini, M., Cory, S., Adams, J. M., & Strasser, A. (2002) · Nature · doi:10.1038/415922a · Cited by 782 · see citing works

Cell Surface Trafficking of Fas: A Rapid Mechanism of p53-Mediated Apoptosis

Bennett, M. R., Macdonald, K., Chan, S., Luzio, J. P., Simari, R. D., & Weissberg, P. L. (1998) · Science · doi:10.1126/science.282.5387.290 · Cited by 755 · see citing works

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

Stennicke, H. R., Jürgensmeier, J. M., Shin, H., Deveraux, Q. L., Wolf, B. B., Yang, X., Zhou, Q., Ellerby, H. M., Ellerby, L., Bredesen, D. E., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.42.27084 · Cited by 747 · see citing works

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

Puthalakath, H., & Strasser, A. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400998 · Cited by 724 · see citing works

Programmed cell death and extrathymic reduction of Vβ8+CD4+ T cells in mice tolerant to Staphylococcus aureus enterotoxin B

Kawabe, Y., & Ochi, A. (1991) · Nature · doi:10.1038/349245a0 · Cited by 703 · see citing works

The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice

Singer, G. G., & Abbas, A. K. (1994) · Immunity · doi:10.1016/1074-7613(94)90067-1 · Cited by 697 · see citing works

Downregulation of Fas ligand by shedding

Tanaka, M., Itai, T., Adachi, M., & Nagata, S. (1998) · Nature Medicine · doi:10.1038/nm0198-031 · Cited by 666 · see citing works

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations

Siegel, R. M., Frederiksen, J. K., Zacharias, D. A., Chan, F. K.-M., Johnson, M. M., Lynch, D. H., Tsien, R. Y., & Lenardo, M. J. (2000) · Science · doi:10.1126/science.288.5475.2354 · Cited by 659 · see citing works

Expression of the functional soluble form of human fas ligand in activated lymphocytes.

Tanaka, M., Suda, T., Takahashi, T., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07096.x · Cited by 639 · see citing works

The role of BH3-only proteins in the immune system

Strasser, A. (2005) · Nature reviews. Immunology · doi:10.1038/nri1568 · Cited by 624 · see citing works

Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis

Petersen, S. L., Wang, L., Yalcin-Chin, A., Li, L., Peyton, M., Minna, J. D., Harran, P. G., & Wang, X. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.029 · Cited by 572 · see citing works

Activated T Cell Death In Vivo Mediated by Proapoptotic Bcl-2 Family Member Bim

Hildeman, D. A., Zhu, Y., Mitchell, T. C., Bouillet, P., Strasser, A., Kappler, J. W., & Marrack, P. (2002) · Immunity · doi:10.1016/s1074-7613(02)00322-9 · Cited by 567 · see citing works

c‐FLIPL is a dual function regulator for caspase‐8 activation and CD95‐mediated apoptosis

Chang, D. W.-W., Xing, Z., Pan, Y., Algeciras‐Schimnich, A., Barnhart, B. C., Yaish‐Ohad, S., Peter, M. E., & Yang, X. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf356 · Cited by 560 · see citing works

Membrane Fas Ligand Kills Human Peripheral Blood T Lymphocytes, and Soluble Fas Ligand Blocks the Killing

Suda, T., Hashimoto, H., Tanaka, M., Ochi, T., & Nagata, S. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.186.12.2045 · Cited by 558 · see citing works

Death Receptor Recruitment of Endogenous Caspase-10 and Apoptosis Initiation in the Absence of Caspase-8

Kischkel, F. C., Lawrence, D. A., Tinel, A., LeBlanc, H. N., Virmani, A. K., Schow, P. W., Gazdar, A. F., Blenis, J., Arnott, D. P., & Ashkenazi, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105102200 · Cited by 536 · see citing works

Fas transduces activation signals in normal human T lymphocytes.

Alderson, M. R., Armitage, R. J., Maraskovsky, E., Tough, T. W., Roux, E. R., Schooley, K., Ramsdell, F., & Lynch, D. H. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.6.2231 · Cited by 520 · see citing works

Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.Preprint

Salmena, L., Lemmers, B., Hakem, A., Matysiak-Zablocki, E., Murakami, K., Au, P. Y. B., Berry, D., Tamblyn, L., Shehabeldin, A., Migon, E., et al. (2003) · Genes & Development · doi:10.1101/gad.1063703 · Cited by 517 · see citing works

Requirement for Casper (c-FLIP) in Regulation of Death Receptor–Induced Apoptosis and Embryonic Development

Yeh, W.-C., Itie, A., Elia, A. J., Ng, M., Shu, H.-B., Wakeham, A., Mirtsos, C., Suzuki, N., Bonnard, M., Goeddel, D. V., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80214-9 · Cited by 515 · see citing works

Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death

Hartley, S. B., Cooke, M. P., Fulcher, D. A., Harris, A. W., Cory, S., Basten, A., & Goodnow, C. C. (1993) · Cell · doi:10.1016/0092-8674(93)90111-3 · Cited by 509 · see citing works

Death receptors in chemotherapy and cancer

Debatin, K., & Krammer, P. H. (2004) · Oncogene · doi:10.1038/sj.onc.1207558 · Cited by 505 · see citing works

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

Newton, K., Harris, A. W., Bath, M. L., Smith, K. G. C., & Strasser, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.3.706 · Cited by 499 · see citing works

The Role of Fas in Autoimmune Diabetes

Chervonsky, A. V., Wang, Y., Wong, F. S., Visintin, I., Flavell, R. A., Janeway, C. A., & Matis, L. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80178-6 · Cited by 489 · see citing works

The Long Form of FLIP Is an Activator of Caspase-8 at the Fas Death-inducing Signaling Complex

Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D. W., Briand, C., & Grütter, M. G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206882200 · Cited by 482 · see citing works

The pleiotropic role of autophagy: from protein metabolism to bactericide

Mizushima, N. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401728 · Cited by 480 · see citing works

FasGene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity

Drappa, J., Vaishnaw, A. K., Sullivan, K. E., Chu, J., & Elkon, K. B. (1996) · New England Journal of Medicine · doi:10.1056/nejm199611283352204 · Cited by 473 · see citing works

CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+T cells

Rathmell, J. C., Cooke, M. P., Ho, W., Grein, J., Townsend, S. E., Davis, M. M., & Goodnow, C. C. (1995) · Nature · doi:10.1038/376181a0 · Cited by 467 · see citing works

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis

Straus, S. E. (2001) · Blood · doi:10.1182/blood.v98.1.194 · Cited by 464 · see citing works

Caspase Activation Is Required for T Cell Proliferation

Kennedy, N. J., Kataoka, T., Tschopp, J., & Budd, R. C. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1891 · Cited by 456 · see citing works

Fas ligand expression in islets of Langerhans does not confer immune privilege and instead targets them for rapid destruction

Kang, S.-M., Schneider, D. B., Lin, Z., Hanahan, D., Dichek, D. A., Stock, P. G., & Bækkeskov, S. (1997) · Nature Medicine · doi:10.1038/nm0797-738 · Cited by 448 · see citing works

Requirement for Caspase-8 in NF-κB Activation by Antigen Receptor

Su, H. C., Bidère, N., Zheng, L., Cubre, A., Sakai, K., Dale, J. K., Salmena, L., Hakem, R., Straus, S. E., & Lenardo, M. J. (2005) · Science · doi:10.1126/science.1104765 · Cited by 427 · see citing works

Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles1

Kang, T., Ben-Moshe, T., Varfolomeev, E., Pewzner‐Jung, Y., Yogev, N., Jurewicz, A., Waisman, A., Brenner, O., Haffner, R., Gustafsson, E., et al. (2004) · Journal of Immunology · doi:10.4049/jimmunol.173.5.2976 · Cited by 425 · see citing works

Protection against Fas-dependent Thl-mediated apoptosis by antigen receptor engagement in B cells

Rothstein, T. L., Wang, J. K., Panka, D. J., Foote, L. C., Wang, Z., Stanger, B. Z., Cui, H., Ju, S., & Marshak‐Rothstein, A. (1995) · Nature · doi:10.1038/374163a0 · Cited by 413 · see citing works

Expansion or Elimination of B Cells In Vivo: Dual Roles for CD40- and Fas (CD95)-Ligands Modulated by the B Cell Antigen Receptor

Rathmell, J. C., Townsend, S. E., Xu, J. C., Flavell, R. A., & Goodnow, C. C. (1996) · Cell · doi:10.1016/s0092-8674(00)81349-5 · Cited by 406 · see citing works

Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide.

Russell, J. H., Rush, B., Weaver, C. T., & Wang, R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4409 · Cited by 398 · see citing works

The CD95 Receptor: Apoptosis Revisited

Peter, M. E., Budd, R. C., Desbarats, J., Hedrick, S. Μ., Hueber, A., Newell, M. K., Owen, L. B., Pope, R. M., Tschopp, J. F., Wajant, H., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.031 · Cited by 396 · see citing works

Cytokine-induced survival of activated T cells in vitro and in vivo

Vella, A. T., DOW, S. W., Potter, T. A., Kappler, J. W., & Marrack, P. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.7.3810 · Cited by 393 · see citing works

Control of Apoptosis in the Immune System: Bcl-2, BH3-Only Proteins and More

Marsden, V. S., & Strasser, A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141029 · Cited by 385 · see citing works

Antigen-induced B-cell death and elimination during germinal-centre immune responses

Shokat, K. M., & Goodnow, C. C. (1995) · Nature · doi:10.1038/375334a0 · Cited by 377 · see citing works

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

Adachi, M., Suematsu, S., Kondo, T., Ogasawara, J., Tanaka, T., Yoshida, N., & Nagata, S. (1995) · Nature Genetics · doi:10.1038/ng1195-294 · Cited by 372 · see citing works

Caspase‐10 is recruited to and activated at the native TRAIL and CD95 death‐inducing signalling complexes in a FADD‐dependent manner but can not functionally substitute caspase‐8

Sprick, M. R., Rieser, E., Stahl, H. F., Große-Wilde, A., Weigand, M. A., & Walczak, H. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf441 · Cited by 364 · see citing works

Transgenic expression of CD95 ligand on islet β cells induces a granulocytic infiltration but does not confer immune privilege upon islet allografts

Allison, J., Georgiou, H. M., Strasser, A., & Vaux, D. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3943 · Cited by 363 · see citing works

The role of B cells in lpr/lpr-induced autoimmunity.

Shlomchik, M. J., Madaio, M. P., Ni, D., et al. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.4.1295 · Cited by 361 · see citing works

Elimination of Antigen-Presenting Cells and Autoreactive T Cells by Fas Contributes to Prevention of Autoimmunity

Stranges, P. B., Watson, J., Cooper, C. J., Choisy-Rossi, C.-M., Stonebraker, A. C., Beighton, R. A., Hartig, H. M., Sundberg, J. P., Servick, S. V., Kaufmann, G. F., et al. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.016 · Cited by 331 · see citing works

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

Pulendran, B., Kannourakis, G., Nouri, S., Smith, K. G. C., & Nossal, G. J. V. (1995) · Nature · doi:10.1038/375331a0 · Cited by 301 · see citing works

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x L

Huang, D. C. S., Hahne, M., Schroeter, M., Frei, K., Fontana, A., Villunger, A., Newton, K., Tschopp, J. F., & Strasser, A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.26.14871 · Cited by 300 · see citing works

Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim inhibits BCR stimulation-induced apoptosis and deletion of autoreactive B cells

Enders, A., Bouillet, P., Puthalakath, H., Xu, Y., Tarlinton, D. M., & Strasser, A. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030411 · Cited by 295 · see citing works

A FADD-dependent innate immune mechanism in mammalian cells

Balachandran, S., Thomas, E., & Barber, G. N. (2004) · Nature · doi:10.1038/nature03124 · Cited by 294 · see citing works

FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells

Bell, B. D., Leverrier, S., Weist, B. M., Newton, R. H., Arechiga, A. F., Luhrs, K. A., Morrissette, N. S., & Walsh, C. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808597105 · Cited by 290 · see citing works

Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes

Kojima, H., Shinohara, N., Hanaoka, S., Shirota-Someya, Y., Takagaki, Y., Ohno, H., Saito, T., Katayama, T., Yagita∥, H., Okumura, K., et al. (1994) · Immunity · doi:10.1016/1074-7613(94)90066-3 · Cited by 286 · see citing works

Activation of CD95 (APO‐1/Fas) signaling by ceramide mediates cancer therapy‐induced apoptosis

Herr, I., Wilhelm, D., Böhler, T., Angel, P., & Debatin, K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6200 · Cited by 279 · see citing works

Apoptosis Regulators Fas and Bim Cooperate in Shutdown of Chronic Immune Responses and Prevention of Autoimmunity

Hughes, P., Belz, G. T., Fortner, K. A., Budd, R. C., Strasser, A., & Bouillet, P. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.017 · Cited by 266 · see citing works

Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

Restifo, N. P. (2000) · Nature Medicine · doi:10.1038/74955 · Cited by 251 · see citing works

FLIP Prevents Apoptosis Induced by Death Receptors But Not by Perforin/Granzyme B, Chemotherapeutic Drugs, and Gamma Irradiation

Kataoka, T., Schröter, M., Hahne, M., Schneider, P., Irmler, M., Thome, M., Froelich, C. J., & Tschopp, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.8.3936 · Cited by 243 · see citing works

Activation of caspases-8 and -10 by FLIPL

Boatright, K. M., Cristina, D. E. I. S., Denault, J., Sutherlin, D. P., & Salvesen, G. S. (2004) · Biochemical Journal · doi:10.1042/bj20040809 · Cited by 242 · see citing works

Opposing Effects of Transmembrane and Soluble FAS Ligand Expression on Inflammation and Tumor Cell Survival

Hohlbaum, A. M., Moe, S., & Marshak‐Rothstein, A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1209 · Cited by 241 · see citing works

Fas engagement accelerates liver regeneration after partial hepatectomy

Desbarats, J., & Newell, M. K. (2000) · Nature Medicine · doi:10.1038/78688 · Cited by 240 · see citing works

Shutdown of an acute T cell immune response to viral infection is mediated by the proapoptotic Bcl-2 homology 3-only protein Bim

Pellegrini, M., Belz, G. T., Bouillet, P., & Strasser, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336198100 · Cited by 238 · see citing works

Reduced Incidence and Delayed Onset of Diabetes in Perforin-deficient Nonobese Diabetic Mice

Kägi, D., Odermatt, B., Seiler, P. J., Zinkernagel, R. M., Mak, T. W., & Hengartner, H. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.989 · Cited by 235 · see citing works

A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling

Gaither, A., PORTER, D. A., Yao, Y., Borawski, J. A., Yang, G., Donovan, J., Sage, D. R., Slisz, J. K., Tran, M., Straub, C. S., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-5173 · Cited by 225 · see citing works

FAS Engagement Induces the Maturation of Dendritic Cells (Dcs), the Release of Interleukin (Il)-1β, and the Production of Interferon γ in the Absence of IL-12 during Dc–T Cell Cognate Interaction

Rescigno, M., Piguet, V., Valzasina, B., Lens, S., Zubler, R. H., French, L. E., Kindler, V., Tschopp, J., & Ricciardi‐Castagnoli, P. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1661 · Cited by 225 · see citing works

Combined Deficiency of Proapoptotic Regulators Bim and Fas Results in the Early Onset of Systemic Autoimmunity

Hutcheson, J., Scatizzi, J. C., Siddiqui, A. M., Haines, G. K., Wu, T., Li, Q., Davis, L. S., Mohan, C., & Perlman, H. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.015 · Cited by 221 · see citing works

Differential Effects of Anti-Fas Ligand and Anti-Tumor Necrosis Factor α Antibodies on Acute Graft-Versus-Host Disease Pathologies

Hattori, K., HIRANO, T., Miyajima, H., Yamakawa, N., Tateno, M., Oshimi, K., Kayagaki, N., Yagita∥, H., & Okumura, K. (1998) · Blood · doi:10.1182/blood.v91.11.4051 · Cited by 216 · see citing works

Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis

Hao, Z., Duncan, G. S., Seagal, J., Su, Y.-W., Hong, C., Haight, J., Chen, N., Elia, A., Wakeham, A. C., Li, W. Y., et al. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.016 · Cited by 211 · see citing works

The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest

Kaufmann, T., Tai, L., Ekert, P. G., Huang, D. C. S., Norris, F., Lindemann, R. K., Johnstone, R. W., Dixit, V. M., & Strasser, A. (2007) · Cell · doi:10.1016/j.cell.2007.03.017 · Cited by 206 · see citing works

T Cell Death and Memory

Sprent, J., & Tough, D. F. (2001) · Science · doi:10.1126/science.1062416 · Cited by 202 · see citing works

Apoptosis Regulators Bim and Fas Function Concurrently to Control Autoimmunity and CD8+ T Cell Contraction

Weant, A. E., Michalek, R. D., Khan, I. U., Holbrook, B. C., Willingham, M. C., & Grayson, J. M. (2008) · Immunity · doi:10.1016/j.immuni.2007.12.014 · Cited by 194 · see citing works

Delivering the kiss of death

Trambas, C., & Griffiths, G. M. (2003) · Nature Immunology · doi:10.1038/ni0503-399 · Cited by 191 · see citing works

Spontaneous Development of Plasmacytoid Tumors in Mice with Defective Fas–Fas Ligand Interactions

Davidson, W. F., Giese, T., & Fredrickson, T. N. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.11.1825 · Cited by 190 · see citing works

T-lymphocyte death during shutdown of an immune response

Strasser, A., & Pellegrini, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.08.012 · Cited by 183 · see citing works

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO‐1)‐transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

Smith, K. G. C., Strasser, A., & Vaux, D. L. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00901.x · Cited by 169 · see citing works

Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2–inhibitable Pathway Mediated by Bim

Davey, G. M., Kurts, C., Miller, J. F. A. P., Bouillet, P., Strasser, A., Brööks, A. G., Carbone, F., & Heath, W. R. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020827 · Cited by 162 · see citing works

A Role for Fas in Negative Selection of Thymocytes In Vivo

Kishimoto, H., Surh, C. D., & Sprent, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1427 · Cited by 161 · see citing works

Disparate roles for TNF-alpha and Fas ligand in concanavalin A-induced hepatitis.

Ksontini, R., Colagiovanni, D. B., Josephs, M. D., Edwards, C. K., Tannahill, C. L., Solórzano, C. C., Norman, J., Denham, W., Clare-Salzler, M. J., MacKay, S. L., et al. (1998) · PubMed · Cited by 156 · see citing works

Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

Russell, J. H., & Wang, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230951 · Cited by 147 · see citing works

FADD/MORT1 regulates the pre‐TCR checkpoint and can function as a tumour suppressor

Newton, K., Harris, A. W., & Strasser, A. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.931 · Cited by 144 · see citing works

Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling

Newton, K., & Strasser, A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.1.195 · Cited by 144 · see citing works

T Cell–specific Ablation of Fas Leads to Fas Ligand–mediated Lymphocyte Depletion and Inflammatory Pulmonary Fibrosis

Hao, Z., Hampel, B., Yagita∥, H., & Rajewsky, K. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20032196 · Cited by 139 · see citing works

Mutation of a Self-Processing Site in Caspase-8 Compromises Its Apoptotic but Not Its Nonapoptotic Functions in Bacterial Artificial Chromosome-Transgenic Mice

Kang, T., Oh, G., Scandella, E., Bolinger, B., Ludewig, B., Kovalenko, A., & Wallach, D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2522 · Cited by 138 · see citing works

Fatal Hepatitis Mediated by Tumor Necrosis Factor TNFα Requires Caspase-8 and Involves the BH3-Only Proteins Bid and Bim

Kaufmann, T., Jost, P. J., Pellegrini, M., Puthalakath, H., Gugasyan, R., Gerondakis, S., Cretney, E., Smyth, M. J., Silke, J., Hakem, R., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.10.017 · Cited by 137 · see citing works

Peripheral T cells undergoing superantigen-induced apoptosis in vivo express B220 and upregulate Fas and Fas ligand.

Renno, T., Hahne, M., Tschopp, J., & MacDonald, H. R. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.2.431 · Cited by 132 · see citing works

Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor

Aggarwal, B. B., Singh, S., LaPushin, R., & Tótpál, K. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00339-b · Cited by 130 · see citing works

Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice

Sidman, C. L., Marshall, J. D., & von Boehmer, H. (1992) · European Journal of Immunology · doi:10.1002/eji.1830220231 · Cited by 130 · see citing works

Germinal centers: form and function

Tarlinton, D. M. (1998) · Current Opinion in Immunology · doi:10.1016/s0952-7915(98)80161-1 · Cited by 128 · see citing works

Flice-Inhibitory Protein Is a Key Regulator of Germinal Center B Cell Apoptosis

Hennino, A., Berard, M., Krammer, P. H., & Defrance, T. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.447 · Cited by 125 · see citing works

An essential role for c-FLIP in the efficient development of mature T lymphocytes

Zhang, N., & He, Y.-W. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050117 · Cited by 123 · see citing works

Massive upregulation of the Fas ligand in lpr and gld mice: implications for Fas regulation and the graft-versus-host disease-like wasting syndrome.

Chu, J. L., Ramos, P. S., Rosendorff, A., Nikolić‐Žugić, J., Lacy, E., Matsuzawa, A., & Elkon, K. B. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.1.393 · Cited by 121 · see citing works

A Function of Fas-Associated Death Domain Protein in Cell Cycle Progression Localized to a Single Amino Acid at Its C-Terminal Region

Hua, Z. C., Sohn, S. J., Kang, C., Cado, D., & Winoto, A. (2003) · Immunity · doi:10.1016/s1074-7613(03)00083-9 · Cited by 119 · see citing works

Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis.

Lagresle‐Peyrou, C., Mondière, P., Bella, C., et al. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.4.1377 · Cited by 116 · see citing works

Constitutive activation of the Fas ligand gene in mouse lymphoproliferative disorders.

Watanabe, D., Suda, T., Hashimoto, H., & Nagata, S. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb06970.x · Cited by 115 · see citing works

Proapoptotic BH3-only protein Bim is essential for developmentally programmed death of germinal center-derived memory B cells and antibody-forming cells

Fischer, S. F., Bouillet, P., O’Donnell, K., Light, A., Tarlinton, D. M., & Strasser, A. (2007) · Blood · doi:10.1182/blood-2007-05-091306 · Cited by 111 · see citing works

Association of lpr gene with graft-vs.-host disease-like syndrome.

Theofilopoulos, A. N., BALDERAS, R. S., Gozes, Y., Aguado, M. T., Hang, L. M., Morrow, P. R., & Dixon, F. J. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.1.1 · Cited by 108 · see citing works

Significant Role for Fas in the Pathogenesis of Autoimmune Diabetes

Su, X., Hu, Q., Kristan, J., Costa, C., Shen, Y. M., Gerő, D., Matis, L. A., & Wang, Y. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.5.2523 · Cited by 107 · see citing works

Mechanisms of β cell death in diabetes: A minor role for CD95

Allison, J., & Strasser, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13818 · Cited by 95 · see citing works

Proapoptotic BH3-Only Protein Bid Is Essential For Death Receptor–Induced Apoptosis of Pancreatic β-Cells

McKenzie, M. D., Carrington, E. M., Kaufmann, T., Strasser, A., Huang, D. C. S., Kay, T. W. H., Allison, J., & Thomas, H. E. (2008) · Diabetes · doi:10.2337/db07-1692 · Cited by 93 · see citing works

Technical Note: Aberrant Detection of Cell Surface Fas Ligand with Anti-Peptide Antibodies

Smith, D. G., Sieg, S. F., & Kaplan, D. R. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.9.4159 · Cited by 84 · see citing works

Role of caspase‐8 in hepatocyte response to infection and injury in mice†

Moshe, T. B., Barash, H., Kang, T., Kim, J., Kovalenko, A., Gross, E., Schuchmann, M., Abramovitch, R., Galun, E., & Wallach, D. (2007) · Hepatology · doi:10.1002/hep.21495 · Cited by 83 · see citing works

The Fas-Associated Death Domain Protein Is Required in Apoptosis and TLR-Induced Proliferative Responses in B Cells

Imtiyaz, H. Z., Rosenberg, S., Zhang, Y., Rahman, Z. S. M., Hou, Y.-J., Manser, T. L., & Zhang, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.6852 · Cited by 79 · see citing works

Transgenic Expression of Fas in T Cells Blocks Lymphoproliferation But Not Autoimmune Disease in MRL- lpr Mice

Fukuyama, H., Adachi, M., Suematsu, S., et al. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.8.3805 · Cited by 78 · see citing works

Effects of a dominant interfering mutant of FADD on signal transduction in activated T cells

Newton, K., Kurts, C., Harris, A. W., & Strasser, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00067-7 · Cited by 76 · see citing works

Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune systemPreprint

Newton, K., & Strasser, A. (2003) · Genes & Development · doi:10.1101/gad.1077403 · Cited by 75 · see citing works

Death of a T cell

Strasser, A. (1995) · Nature · doi:10.1038/373385a0 · Cited by 74 · see citing works

Negative selection of semimature CD4 + 8 - HSA + thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

Villunger, A., Marsden, V. S., Zhan, Y., Erlacher, M., Lew, A. M., Bouillet, P., Berzins, S. P., Godfrey, D. I., Heath, W. R., & Strasser, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0305757101 · Cited by 70 · see citing works

Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes

Rubio, C., Kench, J. A., Russell, D. M., et al. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.157.1.65 · Cited by 68 · see citing works

Involvement of Fas-Mediated Apoptosis in the Hematopoietic Progenitor Cells of Graft-Versus-Host Reaction-Associated Myelosuppression

Mori, T., Nishimura, T., Ikeda, Y., et al. (1998) · Blood · doi:10.1182/blood.v92.1.101.413k14_101_107 · Cited by 67 · see citing works

The Requirements for Fas-Associated Death Domain Signaling in Mature T Cell Activation and Survival

Beisner, D. R., Chu, I. H., Arechiga, A. F., Hedrick, S. Μ., & Walsh, C. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.247 · Cited by 66 · see citing works

Increased cytotoxicity of soluble Fas ligand by fusing isoleucine zipper motif

Shiraishi, T., Suzuyama, K., Okamoto, H., Mineta, T., Tabuchi, K., Nakayama, K., Shimizu, Y. I., Tohma, J., Ogihara, T., Naba, H., et al. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.098 · Cited by 62 · see citing works

The shared tumor-specific antigen encoded by mouse geneP1A is a target not only for cytolytic T lymphocytes but also for tumor rejection

Brändle, D., Bilsborough, J., Rülicke, T., Uyttenhove, C., Boon, T., & den Eynde, B. J. V. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199812)28:12 · Cited by 62 · see citing works

FADD and caspase-8 are required for cytokine-induced proliferation of hemopoietic progenitor cells

Pellegrini, M., Bath, S., Marsden, V. S., Huang, D. C. S., Metcalf, D., Harris, A. W., & Strasser, A. (2005) · Blood · doi:10.1182/blood-2005-01-0284 · Cited by 59 · see citing works

Secretory phospholipases A2 induce cytokine release from blood and synovial fluid monocytes

Triggiani, M., Granata, F., Oriente, A., Gentile, M., Petraroli, A., Balestrieri, B., & Marone, G. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200201)32:1 · Cited by 59 · see citing works

BH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection

Fischer, S. F., Belz, G. T., & Strasser, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706913105 · Cited by 59 · see citing works

Life and death during hematopoietic differentiation

Opferman, J. T. (2007) · Current Opinion in Immunology · doi:10.1016/j.coi.2007.06.002 · Cited by 58 · see citing works

A novel murine anti-human Fas mAb which mitigates lymphadenopathy without hepatotoxicity

Ichikawa, K., Yoshida-Kato, H., Ohtsuki, M., et al. (2000) · International Immunology · doi:10.1093/intimm/12.4.555 · Cited by 54 · see citing works

bcl-2 transgenic Lpr mice show profound enhancement of lymphadenopathy

Reap, E. A., Felix, N. J., Wolthusen, P. A., et al. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.11.5455 · Cited by 53 · see citing works

Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes

O’Reilly, L. A., Divisekera, U., Newton, K., Scalzo‐Inguanti, K., Kataoka, T., Puthalakath, H., Ito, M., Huang, D. C. S., & Strasser, A. (2004) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401408 · Cited by 47 · see citing works

Spatial differences in active caspase-8 defines its role in T-cell activation versus cell death

Koenig, A., Russell, J. Q., Rodgers, W., et al. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.100 · Cited by 47 · see citing works

Fas-Mediated Apoptosis of the Hematopoietic Progenitor Cells in Mice Infected With Murine Cytomegalovirus

Mori, T., Ando, K., TANAKA, K. A., et al. (1997) · Blood · doi:10.1182/blood.v89.10.3565.3565_3565_3573 · Cited by 39 · see citing works

Prevention of Autoimmunity and Control of Recall Response to Exogenous Antigen by Fas Death Receptor Ligand Expression on T Cells

Mabrouk, I., Buart, S., Hasmim, M., Michiels, C., Connault, E., Opolon, P., Chiocchia, G., Lévi‐Strauss, M., Chouaı̈b, S., & Karray, S. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.007 · Cited by 39 · see citing works

Fas-Mediated Apoptosis of the Hematopoietic Progenitor Cells in Mice Infected With Murine Cytomegalovirus

Mori, T., Ando, K., TANAKA, K. A., et al. (1997) · Blood · doi:10.1182/blood.v89.10.3565 · Cited by 36 · see citing works

Suicide by order: Some open questions about the cell-killing activities of the TNF ligand and receptor families

Wallach, D. (1996) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(96)00032-9 · Cited by 33 · see citing works

Inhibition of Apoptosis and Augmentation of Lymphoproliferation inbcl-2Transgenic Fas/Fas Ligand-Defective Mice

Tamura, A., Katsumata, M., Greene, M. I., et al. (1996) · Cellular Immunology · doi:10.1006/cimm.1996.0069 · Cited by 24 · see citing works

NF-κB Is Required for Surface Ig-Induced Fas Resistance in B Cells

Schram, B. R., & Rothstein, T. L. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.6.3118 · Cited by 24 · see citing works

Severe impairment of B cell function in lpr/lpr mice expressing transgenic Fas selectively on B cells

Komano, H., Ikegami, Y., Yokoyama, M., et al. (1999) · International Immunology · doi:10.1093/intimm/11.7.1035 · Cited by 20 · see citing works

A FAScinating Receptor in Self-Tolerance

Ramaswamy, M., & Siegel, R. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.05.004 · Cited by 11 · see citing works

Untitled work

Tsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6

Untitled work

Bischof, A. (2000) · doi:10.1002/1521-4141(200003)30:3

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

Czabotar, P. E., Lessene, G., Strasser, A., & Adams, J. M. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3722 · Cited by 3,219 · see citing works

Overview of the immune response

Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235 · see citing works

Programmed Cell Death in Animal Development and Disease

Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915 · see citing works

How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression

Aubrey, B. J., Kelly, G. L., Janic, A., Herold, M. J., & Strasser, A. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.169 · Cited by 1,395 · see citing works

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Godoy, P., Hewitt, N. J., Albrecht, U., Andersen, M. E., Ansari, N., Bhattacharya, S., Bode, J. G., Bolleyn, J., Borner, C., Böttger, J., et al. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1078-5 · Cited by 1,280 · see citing works

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

Zengerle, M., Chan, K.-H., & Ciulli, A. (2015) · ACS Chemical Biology · doi:10.1021/acschembio.5b00216 · Cited by 1,056 · see citing works

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

Kaiser, W. J., Upton, J. W., Long, A. B., Livingston-Rosanoff, D., Daley-Bauer, L. P., Hakem, R., Caspary, T., & Mocarski, E. S. (2011) · Nature · doi:10.1038/nature09857 · Cited by 1,057 · see citing works

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Galluzzi, L., Bravo-San Pedro, J. M., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Alnemri, E. S., Altucci, L., Andrews, D., Annicchiarico-Petruzzelli, M., et al. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.137 · Cited by 1,002 · see citing works

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

Yuan, J., Amin, P., & Ofengeim, D. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0093-1 · Cited by 967 · see citing works

XIAP discriminates between type I and type II FAS-induced apoptosis

Jost, P. J., Grabow, S., Gray, D., McKenzie, M. D., Nachbur, U., Huang, D. C. S., Bouillet, P., Thomas, H. E., Borner, C., Silke, J., et al. (2009) · Nature · doi:10.1038/nature08229 · Cited by 482 · see citing works

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

Roederer, M., Quaye, L., Mangino, M., Beddall, M. H., Mahnke, Y., Chattopadhyay, P., Tosi, I., Napolitano, L., Terranova Barberio, M., Menni, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.046 · Cited by 296 · see citing works

The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation

Birkinshaw, R. W., & Czabotar, P. E. (2017) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2017.04.001 · Cited by 229 · see citing works

Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor

Fu, Q., Fu, T.-M., Cruz, A. C., Sengupta, P., Thomas, S. K., Wang, S., Siegel, R. M., Wu, H., & Chou, J. J. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.009 · Cited by 191 · see citing works

Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model

Schleich, K., Warnken, U., Fricker, N., Öztürk, S., Richter, P., Kammerer, K., Schnölzer, M., Krammer, P. H., & Lavrik, I. N. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.05.006 · Cited by 198 · see citing works

Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex

Fu, T.-M., Li, Y., Lu, A., Li, Z., Vajjhala, P. R., Cruz, A. C., Srivastava, D. B., DiMaio, F., Penczek, P. A., Siegel, R. M., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.009 · Cited by 196 · see citing works

Apoptosis and other immune biomarkers predict influenza vaccine responsiveness

Furman, D., Jojic, V., Kidd, B., Shen‐Orr, S., Price, J., Jarrell, J., Tse, T., Huang, H., Lund, P., Maecker, H. T., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.15 · Cited by 184 · see citing works

Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies

Roth, T. L., Li, P. J., Blaeschke, F., Nies, J. F., Apathy, R., Mowery, C., Yu, R., Nguyen, M. L. T., Lee, Y., Truong, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.039 · Cited by 186 · see citing works

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

Horiguchi, H., Loftus, T. J., Hawkins, R. B., Raymond, S. L., Stortz, J. A., Hollen, M. K., Weiss, B. P., Miller, E. S., Bihorac, A., Larson, S. D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00595 · Cited by 164 · see citing works

Cytokine and Chemokine Signals of T‐Cell Exclusion in Tumors

Zhang, Y., Guan, X.-Y., & Jiang, P. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594609 · Cited by 133 · see citing works

Hsp90: A New Player in DNA Repair?

Pennisi, R., Ascenzi, P., & Di Masi, A. (2015) · Biomolecules · doi:10.3390/biom5042589 · Cited by 112 · see citing works

Consequences of the combined loss of BOK and BAK or BOK and BAX

Ke, F., Bouillet, P., Kaufmann, T., Strasser, A., Kerr, J., & Voss, A. K. (2013) · Cell Death & Disease · doi:10.1038/cddis.2013.176 · Cited by 72 · see citing works

The Tumor Necrosis Factor Family: Family Conventions and Private Idiosyncrasies

Wallach, D. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028431 · Cited by 66 · see citing works

Mesenchymal stem cells inhibit multiple myeloma cells via the Fas/Fas ligand pathway

Atsuta, I., Liu, S., Miura, Y., Akiyama, K., Chen, C., An, Y., Shi, S., & Chen, F.-M. (2013) · Stem Cell Research & Therapy · doi:10.1186/scrt322 · Cited by 57 · see citing works

Mitochondrial DNA and Exercise: Implications for Health and Injuries in Sports

Zanini, G., De Gaetano, A., Selleri, V., Savino, G., Cossarizza, A., Pinti, M., Mattioli, A. V., & Nasi, M. (2021) · Cells · doi:10.3390/cells10102575 · Cited by 46 · see citing works

Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family

Schilling, T., Schleithoff, E. S., Kairat, A., Melino, G., Stremmel, W., Oren, M., Krammer, P. H., & Müller, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.07.063 · Cited by 43 · see citing works

MOAP-1 Mediates Fas-Induced Apoptosis in Liver by Facilitating tBid Recruitment to Mitochondria

Tan, C. T., Zhou, Q.-L., Su, Y.-C., Fu, N. Y., Chang, H.-C., Tao, R. N., Sukumaran, S. K., Baksh, S., Tan, Y.-J., Sabapathy, K., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.068 · Cited by 35 · see citing works

Functional categories of immune inhibitory receptors

Rumpret, M., Drylewicz, J., Ackermans, L. J. E., Borghans, J. A. M., Medzhitov, R. M., & Meyaard, L. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0352-z · Cited by 92 · see citing works

Inhibitory and Coactivating Receptors Recognising the Same Ligand: Immune Homeostasis Exploited by Pathogens and Tumours

Levi‐Schaffer, F., & Mandelboim, O. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.10.001 · Cited by 27 · see citing works

Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease

Agnati, L. F., Leo, G., Genedani, S., et al. (2007) · The Scientific World JOURNAL · doi:10.1100/tsw.2007.166 · Cited by 2 · see citing works

Molecular Aspects of Cannabinoid Receptors

Matsuda, L. A. (1997) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v11.i2-3.30 · Cited by 132 · see citing works

BINDING OF SOLUBLE IMMUNE COMPLEXES TO HUMAN LYMPHOBLASTOID CELLS

Theofilopoulos, A. N., Dixon, F. J., & Bokisch, V. A. (1974) · The Journal of Experimental Medicine · doi:10.1084/jem.140.4.877 · Cited by 147 · see citing works