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Cited by 465

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

Open access
Yamada, Toshiya, Pfaff, Samuel L., Edlund, Thomas, Jessell, Thomas M.·1993·Cell

Abstract

The identity of cell types generated along the dorsoventral axis of the neural tube depends on inductive signals that derive from both mesodermal and neural cells. To define the nature of these signals, we have analyzed the differentiation of cells in neural plate explants. Motor neurons and neural crest cells differentiate in vitro from appropriate regions of the neural plate, indicating that the specification of cell fate along the dorsoventral axis of the neural tube begins at the neural plate stage. Motor neuron differentiation can be induced by a diffusible factor that derives initially from the notochord and later from floor plate cells. By contrast, floor plate induction requires contact with the notochord. Thus, the identity and patterning of neural cell types appear to involve distinct contact-mediated and diffusible signals from the notochord and floor plate.

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Crossref · 10.1016/0092-8674(93)90248-o

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Metadata

Authors
Yamada, T., Pfaff, S. L., Edlund, T., & Jessell, T. M.
Venue
Cell
Publisher
Elsevier BV
Published
1993-05
Volume
73
Issue
4
Pages
673-686
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2049859215
Cited by
465
References
47
FWCI
18.86
Type
journal article
Language
en
Open access
hybrid

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CoChat. (2026). Citation check: Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate. https://app.cochat.ai/papers/10.1016/0092-8674(93)90248-o
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Yamada, T., Pfaff, S. L., Edlund, T., & Jessell, T. M. (1993). Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate. Cell. https://doi.org/10.1016/0092-8674(93)90248-o

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.