Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1
Abstract
Motor neurons in the embryonic chick spinal cord express a homeobox gene, Islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of Islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish Islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.
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The prominence of motor neurons at early stages is consistent with the initially high differentiation rate of MN progenitors.
“which is consistent with the initially high differentiation rate of MN progenitors”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Ericson et al., 1992
Cites
A series of normal stages in the development of the chick embryo
Hamburger, V., & Hamilton, H. L. (1951) · Journal of Morphology · doi:10.1002/jmor.1050880104 · Cited by 12,254 · see citing works
Homeobox genes and axial patterning
McGinnis, W., & Krumlauf, R. (1992) · Cell · doi:10.1016/0092-8674(92)90471-n · Cited by 2,674 · see citing works
Erratum: Mouse Small eye results from mutation in a paired-like homebox-containing gene
Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C. C. T., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D., & van Heyningen, V. (1992) · Nature · doi:10.1038/355750a0 · Cited by 1,270 · see citing works
Pax-6, a murine paired box gene, is expressed in the developing CNS
Walther, C., & Gruß, P. (1991) · Development · doi:10.1242/dev.113.4.1435 · Cited by 1,258 · see citing works
Mouse Small eye results from mutations in a paired-like homeobox-containing gene
Hill, R. E., Favor, J., Hogan, B. L. M., Ton, C. C. T., Saunders, G. F., Hanson, I. M., Prosser, J., Jordan, T., Hastie, N. D., & van Heyningen, V. (1991) · Nature · doi:10.1038/354522a0 · Cited by 1,159 · see citing works
Graham, A., Papalopulu, N., & Krumlauf, R. K. (1989) · Cell · doi:10.1016/0092-8674(89)90912-4 · Cited by 1,004 · see citing works
The structure and function of the homeodomain
Scott, M. P., Tamkun, J. W., & Hartzell, G. (1989) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(89)90033-4 · Cited by 995 · see citing works
Duboule, D., & Dollé, P. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03534.x · Cited by 941 · see citing works
Pax‐3, a novel murine DNA binding protein expressed during early neurogenesis.
Goulding, M., Chalepakis, G., Deutsch, U., et al. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb08054.x · Cited by 926 · see citing works
Ton, C. C. T., Hirvonen, H., Miwa, H., Weil, M. M., Monaghan, P., Jordan, T., van Heyningen, V., Hastie, N. D., Meijers-Heijboer, H. E. J., Drechsler, M., et al. (1991) · Cell · doi:10.1016/0092-8674(91)90284-6 · Cited by 862 · see citing works
Chisaka, O., & Capecchi, M. R. (1991) · Nature · doi:10.1038/350473a0 · Cited by 853 · see citing works
Cell Cycle Dependence of Laminar Determination in Developing Neocortex
McConnell, S. K., & Kaznowski, C. E. (1991) · Science · doi:10.1126/science.1925583 · Cited by 712 · see citing works
Yamada, T., Placzek, M., Tanaka, H., Dodd, J., & Jessell, T. M. (1991) · Cell · doi:10.1016/0092-8674(91)90247-v · Cited by 707 · see citing works
Self-citationLufkin, T., Dierich, A., LeMeur, M., Mark, M. P., & Chambon, P. (1991) · Cell · doi:10.1016/0092-8674(91)90034-v · Cited by 696 · see citing works
Karlsson, O. P., Thor, S., Norberg, T., Ohlsson, H., & Edlund, H. (1990) · Nature · doi:10.1038/344879a0 · Cited by 687 · see citing works
Self-citationEpstein, D. J., Vekemans, M. J. J., & Gros, P. (1991) · Cell · doi:10.1016/0092-8674(91)90071-6 · Cited by 670 · see citing works
The Agrin HypothesisPreprint
McMahan, U. J. (1990) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1990.055.01.041 · Cited by 643 · see citing works
Way, J. C., & Chalfie, M. (1988) · Cell · doi:10.1016/0092-8674(88)90174-2 · Cited by 564 · see citing works
Freyd, G., Kim, S. K., & Horvitz, H. R. (1990) · Nature · doi:10.1038/344876a0 · Cited by 548 · see citing works
A distinct Hox code for the branchial region of the vertebrate head
Hunt, P., Gulisano, M., Cook, M., Sham, M. H., Faiella, A., Wilkinson, D. G., Boncinelli, E., & Krumlauf, R. K. (1991) · Nature · doi:10.1038/353861a0 · Cited by 498 · see citing works
Frank, E., & Fischbach, G. D. (1979) · The Journal of Cell Biology · doi:10.1083/jcb.83.1.143 · Cited by 347 · see citing works
Thor, S., Ericson, J., Brännström, T., & Edlund, H. (1991) · Neuron · doi:10.1016/0896-6273(91)90334-v · Cited by 333 · see citing works
Self-citationMesodermal Control of Neural Cell Identity: Floor Plate Induction by the Notochord
Placzek, M., Tessier‐Lavigne, M., Yamada, T., Jessell, T. M., & Dodd, J. (1990) · Science · doi:10.1126/science.2237443 · Cited by 302 · see citing works
Self-citationAn autoradiographic study of the formation of the lateral motor column in the chick embryo
Hollyday, M., & Hamburger, V. (1977) · Brain Research · doi:10.1016/0006-8993(77)90416-4 · Cited by 297 · see citing works
Lineage, arrangement, and death of clonally related motoneurons in chick spinal cord
Leber, S., Breedlove, S., & Sanes, J. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-07-02451.1990 · Cited by 262 · see citing works
Pathway selection by chick lumbosacral motoneurons during normal development
Lance-Jones, C. C., & Landmesser, L. T. (1981) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1981.0079 · Cited by 228 · see citing works
The origin and development of the visceral in the spinal cord of the chick embryo
Levi‐Montalcini, R. (1950) · Journal of Morphology · doi:10.1002/jmor.1050860203 · Cited by 210 · see citing works
Behavior of neuro‐epithelial cells during closure of the neural tube
Langman, J., Guerrant, R. L., & Freeman, B. G. (1966) · The Journal of Comparative Neurology · doi:10.1002/cne.901270308 · Cited by 202 · see citing works
Molecular cloning and expression of a novel adhesion molecule, SC1
Tanaka, H., Matsui, T., Agata, A., Tomura, M., Kubota, I., McFarland, K., Kohr, B., Lee, A. L., PHILLIPS, H. S., & Shelton, D. L. (1991) · Neuron · doi:10.1016/0896-6273(91)90366-8 · Cited by 188 · see citing works
Oppenheim, R. W., Maderdrut, J. L., & Wells, D. J. (1982) · The Journal of Comparative Neurology · doi:10.1002/cne.902100208 · Cited by 146 · see citing works
Formation and migration of neuroblasts in the spinal cord of the chick embryo
Langman, J., & Haden, C. C. (1970) · The Journal of Comparative Neurology · doi:10.1002/cne.901380403 · Cited by 134 · see citing works
Determination of Primary Motoneuron Identity in Developing Zebrafish Embryos
Eisen, J. S. (1991) · Science · doi:10.1126/science.1708527 · Cited by 133 · see citing works
Tanaka, H., & Obata, K. (1984) · Developmental Biology · doi:10.1016/0012-1606(84)90057-5 · Cited by 124 · see citing works
Bloch‐Gallego, E., Huchet, M., M’Hamdi, H., et al. (1991) · Development · doi:10.1242/dev.111.1.221 · Cited by 97 · see citing works
Role of cell-cycle in regulating neuroepithelial cell shape during bending of the chick neural plate
Smith, J., & Schoenwolf, G. C. (1988) · Cell and Tissue Research · doi:10.1007/bf00216636 · Cited by 96 · see citing works
Onset and development of intersegmental projections in the chick embryo spinal cord
Oppenheim, R. W., Shneiderman, A., Shimizu, I., et al. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902750202 · Cited by 83 · see citing works
van Straaten, H. W. M., Thors, F., Wiertz-Hoessels, L., et al. (1985) · Developmental Biology · doi:10.1016/0012-1606(85)90081-8 · Cited by 82 · see citing works
Carpenter, E. M., & Hollyday, M. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90014-8 · Cited by 39 · see citing works
McEvoy, P. (1988) · PubMed · Cited by 4 · see citing works
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Conversion of <i>Xenopus</i> Ectoderm into Neurons by NeuroD, a Basic Helix-Loop-Helix Protein
Lee, J. E., Hollenberg, S. M., Snider, L., Turner, D. L., Lipnick, N., & Weintraub, H. (1995) · Science · doi:10.1126/science.7754368 · Cited by 1,023 · see citing works
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Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A. (1998) · Science · doi:10.1126/science.280.5369.1603 · Cited by 848 · see citing works
Novitch, B. G., Chen, A. I., & Jessell, T. M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00407-x · Cited by 615 · see citing works
Self-citationEricson, J., Muhr, J., Placzek, M., Lints, T., Jessel, T. M., & Edlund, T. (1995) · Cell · doi:10.1016/0092-8674(95)90536-7 · Cited by 553 · see citing works
Self-citationDe Vries, G. J., Rissman, E. F., Simerly, R. B., Yang, L.-Y., Scordalakes, E. M., Auger, C. J., Swain, A., Lovell-Badge, R., Burgoyne, P. S., & Arnold, A. P. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-20-09005.2002 · Cited by 509 · see citing works
Delile, J., Rayon, T., Melchionda, M., Edwards, A., Briscoe, J., & Sagner, A. (2019) · Development · doi:10.1242/dev.173807 · Cited by 356 · see citing works
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Kim, S. K., Hebrok, M., & Melton, D. A. (1997) · Development · doi:10.1242/dev.124.21.4243 · Cited by 405 · see citing works
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Sances, S., Bruijn, L. I., Chandran, S., Eggan, K., Ho, R., Klim, J. R., Livesey, M. R., Lowry, E., Macklis, J. D., Rushton, D., et al. (2016) · Nature Neuroscience · doi:10.1038/nn.4273 · Cited by 289 · see citing works
Fragkouli, A., van Wijk, N. V., Lopes, R., Kessaris, N., & Pachnis, V. (2009) · Development · doi:10.1242/dev.038083 · Cited by 135 · see citing works
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Liang, X., Song, M.-R., Xu, Z., Lanuza, G. M., Liu, Y., Zhuang, T., Chen, Y., Pfaff, S. L., Evans, S. M., & Sun, Y. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.04.007 · Cited by 100 · see citing works
Sagner, A., Gaber, Z. B., Delile, J., Kong, J. H., Rousso, D. L., Pearson, C. A., Weicksel, S. E., Melchionda, M., Mousavy Gharavy, S. N., Briscoe, J., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2003127 · Cited by 96 · see citing works
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- Authors
- Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T.
- Affiliations
- Umeå University (SE)
- Department of Microbiology, Umeå University, Umeå S-90187, Sweden.
- Howard Hughes Medical Institute (US)
- Venue
- Science
- Published
- 1992-06-12
- Volume
- 256
- Issue
- 5063
- Pages
- 1555-1560
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977350867
- Cited by
- 620
- References
- 39
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 5 · 2020: 14 · 2019: 17 · 2018: 10 · 2017: 2 · 2016: 9 · 2015: 11 · 2014: 15 · 2013: 16 · 2012: 15
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Keywords
- Islet1, homeobox genes, motor neuron differentiation, floor plate, notochord, spinal cord development, chick embryo, neural induction, neuronal differentiation markers
- MeSH terms
- Animals, Cell Differentiation, Chick Embryo, Embryonic Induction, Genes, Homeobox, Immunoenzyme Techniques, Motor Neurons, Notochord, Spinal Cord, Gene Expression
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