Cited by 620Developmental Biology and Gene RegulationNeurogenesis and neuroplasticity mechanismsAxon Guidance and Neuronal Signaling

Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

Ericson, Johan, Thor, Stefan, Edlund, Thomas, Jessell, Thomas M., Yamada, Toshiya·1992·Science

Abstract

Motor neurons in the embryonic chick spinal cord express a homeobox gene, Islet-1, soon after their final mitotic division and before the appearance of other differentiated motor neuron properties. The expression of Islet-1 by neural cells is regulated by inductive signals from the floor plate and notochord. These results establish Islet-1 as the earliest marker of developing motor neurons. The molecular nature of the Islet-1 protein suggests that it may be involved in the establishment of motor neuron fate.

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Crossref · 10.1126/science.1350865

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39 of 39 references verified0 citation errors · 0 not checkable

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Authors
Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T.
Affiliations
  • Umeå University (SE)
  • Department of Microbiology, Umeå University, Umeå S-90187, Sweden.
  • Howard Hughes Medical Institute (US)
Venue
Science
Published
1992-06-12
Volume
256
Issue
5063
Pages
1555-1560
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1977350867
Cited by
620
References
39
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 13 · 2021: 5 · 2020: 14 · 2019: 17 · 2018: 10 · 2017: 2 · 2016: 9 · 2015: 11 · 2014: 15 · 2013: 16 · 2012: 15
FWCI
10.53
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Keywords
Islet1, homeobox genes, motor neuron differentiation, floor plate, notochord, spinal cord development, chick embryo, neural induction, neuronal differentiation markers
MeSH terms
Animals, Cell Differentiation, Chick Embryo, Embryonic Induction, Genes, Homeobox, Immunoenzyme Techniques, Motor Neurons, Notochord, Spinal Cord, Gene Expression

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