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Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

Shultz, Leonard D., Schweitzer, Peter A., Rajan, T.V., Yi, Taolin, Ihle, James N., Matthews, R. James, Thomas, Matthew L., Beier, David R.·1993·Cell
DOI 10.1016/0092-8674(93)90369-2
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Abstract

Mice homozygous for the recessive allelic mutation motheaten (me) or viable motheaten (mev) on chromosome 6 develop severe defects in hematopoiesis. In this paper we present the findings that the me and mev mutations are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. High resolution mapping localized me to an area tightly linked to Hcph on chromosome 6. Abnormalities of the Hcph protein product were demonstrated by Western blot analysis and by activity assays in both me/me and mev/mev mice. Molecular analysis of the Hcph cDNA identified abnormal transcripts in both mutants. DNA sequence analyses of cDNA and genomic clones revealed that both the me and mev mutations are point mutations that result in aberrant splicing of the Hcph transcript. These findings provide the first available animal models for a specific protein-tyrosine phosphatase deficiency, thus facilitating determination of the precise role of this signaling molecule in hematopoiesis.

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Metadata

Authors
Shultz, L. D., Schweitzer, P. A., Rajan, T. V., Yi, T., Ihle, J. N., Matthews, R. J., Thomas, M. L., & Beier, D. R.
Venue
Cell
Publisher
Elsevier BV
Published
1993-07
Volume
73
Issue
7
Pages
1445-1454
ISSN
0092-8674
DOI
10.1016/0092-8674(93)90369-2
Cited by
581
References
0
Language
en
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