The DOI matches its Crossref record; 61 of the 76 references it cites were found in a registry or an index.
The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage
Open accessAbstract
We have isolated cDNA clones of myeloid differentiation primary response (MyD) genes, activated in the absence of de novo protein synthesis following induction for differentiation along either the macrophage or granulocyte lineage in human myeloblastic leukemia HL-60 cells. One cDNA clone of a primary response gene, expressed upon macrophage differentiation, encoded for Egr-1, a zinc finger transcription factor. The Egr-1 gene was observed to be transcriptionally silent in HL-60 cells, but active in U-937 and M1 cells, the latter two being predetermined for macrophage differentiation. Egr-1 antisense oligomers in the culture media blocked macrophage differentiation in both myeloid leukemia cell lines and normal myeloblasts. HL-60 cells constitutively expressing an Egr-1 transgene (HL-60Egr-1) could be induced for macrophage, but not granulocyte, differentiation. These observations indicate that expression of Egr-1 is essential for and restricts differentiation of myeloblasts along the macrophage lineage.
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“It is interesting to note that ICSBP induces a zinc finger transcription factor Egr-1 that has been implicated in macrophage differentiation, (57)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [57]
In the citing paper
“It is interesting to note that ICSBP induces a zinc finger transcription factor Egr-1 that has been implicated in macrophage differentiation, (57)”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [57]
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Metadata
- Authors
- Nguyen, H. Q., Hoffman-Liebermann, B., & Liebermann, D. A.
- Affiliations
- University of Pennsylvania (US)
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1993-01
- Volume
- 72
- Issue
- 2
- Pages
- 197-209
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1993004730
- Cited by
- 367
- References
- 76
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 7
- FWCI
- 21.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Cell (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ca043618-12)
- National Cancer Institute (1RO1CA43618-01)
- Topics
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- EGR1, zinc finger transcription factor, macrophage differentiation, granulocytic differentiation, HL-60 cells, U937 cells, M1 cells, antisense oligomers, transgene expression, myeloblasts, transcriptional regulation
- MeSH terms
- Animals, Base Sequence, Binding Sites, Bone Marrow, Bone Marrow Cells, Cell Differentiation, Cell Nucleus, Dimethyl Sulfoxide, DNA-Binding Proteins, DNA, Neoplasm, Granulocytes, Hematopoietic Stem Cells, Humans, Macrophages, Mice, Inbred Strains, Molecular Sequence Data, Poly A, RNA, RNA, Messenger, Tetradecanoylphorbol Acetate, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Leukemia, Promyelocytic, Acute, Gene Expression, Zinc Fingers, Oligonucleotides, Antisense, Immediate-Early Proteins, Mice, Early Growth Response Protein 1
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