Cited by 367Acute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processesGenomics and Chromatin Dynamics

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The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

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Nguyen, Hung Q., Hoffman-Liebermann, Barbara, Liebermann, Dan A.·1993·Cell

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Abstract

We have isolated cDNA clones of myeloid differentiation primary response (MyD) genes, activated in the absence of de novo protein synthesis following induction for differentiation along either the macrophage or granulocyte lineage in human myeloblastic leukemia HL-60 cells. One cDNA clone of a primary response gene, expressed upon macrophage differentiation, encoded for Egr-1, a zinc finger transcription factor. The Egr-1 gene was observed to be transcriptionally silent in HL-60 cells, but active in U-937 and M1 cells, the latter two being predetermined for macrophage differentiation. Egr-1 antisense oligomers in the culture media blocked macrophage differentiation in both myeloid leukemia cell lines and normal myeloblasts. HL-60 cells constitutively expressing an Egr-1 transgene (HL-60Egr-1) could be induced for macrophage, but not granulocyte, differentiation. These observations indicate that expression of Egr-1 is essential for and restricts differentiation of myeloblasts along the macrophage lineage.

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Authors: Nguyen, H. Q., Hoffman-Liebermann, B., & Liebermann, D. A.
Affiliations: University of Pennsylvania (US)
ORCID: Nguyen, Hung Q.
Liebermann, Dan A.
Venue: Cell
Publisher: Elsevier BV
Published: 1993-01
Volume: 72
Issue: 2
Pages: 197-209
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(93)90660-i
OpenAlex: W1993004730
Cited by: 367
References: 76
Citations by year: 2026: 3 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 5 · 2014: 6 · 2013: 7 · 2012: 7
FWCI: 21.10
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 4619 d)
Locations: Cell (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ca043618-12)
National Cancer Institute (1RO1CA43618-01)
Topics: Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: EGR1, zinc finger transcription factor, macrophage differentiation, granulocytic differentiation, HL-60 cells, U937 cells, M1 cells, antisense oligomers, transgene expression, myeloblasts, transcriptional regulation
MeSH terms: Animals, Base Sequence, Binding Sites, Bone Marrow, Bone Marrow Cells, Cell Differentiation, Cell Nucleus, Dimethyl Sulfoxide, DNA-Binding Proteins, DNA, Neoplasm, Granulocytes, Hematopoietic Stem Cells, Humans, Macrophages, Mice, Inbred Strains, Molecular Sequence Data, Poly A, RNA, RNA, Messenger, Tetradecanoylphorbol Acetate, Transcription Factors, Transcription, Genetic, Transfection, Tumor Cells, Cultured, Leukemia, Promyelocytic, Acute, Gene Expression, Zinc Fingers, Oligonucleotides, Antisense, Immediate-Early Proteins, Mice, Early Growth Response Protein 1

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The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

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