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Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene
Open accessAbstract
The Drosophila eye consists of a reiterative hexagonal array of photoreceptor cell clusters, the ommatidia. During normal morphogenesis, the clusters in the dorsal or ventral halves of the disc rotate 90 degrees in opposite directions, forming mirror images across a dorsoventral equator. In the mutant nemo (nmo), there is an initial turning of approximately 45 degrees, but further rotation is blocked. Genetic mosaic analysis indicates that the nmo gene acts upon each cluster as a whole; normal nmo function in one or more photoreceptor cells appears to be sufficient to induce full rotation. The nmo gene sequence encodes a serine/threonine protein kinase homolog, suggesting that the kinase is required to initiate the second step of rotation. In another mutant, roulette, excessive rotation through varying angles occurs in many ommatidia. This defect is suppressed by nmo, indicating that nmo acts upstream in a rotation-regulating pathway.
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“NLK is an evolutionarily conserved serine/threonine protein kinase (Choi and Benzer, 1994; Banfi et al., 1996; Brott et al., 1998; Meneghini et al., 1999).”
From Polyglutamine Disease Toxicity Is Regulated by Nemo-like Kinase in Spinocerebellar Ataxia Type 1 (2013) · cites this paper as Choi and Benzer, 1994
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“was originally identified in 1994 as the Drosophila gene nemo required for proper rotation of photoreceptor cells in the eye during ommatidia morphogenesis [14].”
From Nemo-Like Kinase in Development and Diseases: Insights from Mouse Studies (2020) · cites this paper as [14]
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Metadata
- Authors
- Choi, K.-W., & Benzer, S.
- Affiliations
- California Institute of Technology (US)
- ORCID
- Choi, Kwang-Wook
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1994-07
- Volume
- 78
- Issue
- 1
- Pages
- 125-136
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1975803734
- Cited by
- 339
- References
- 49
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 10
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (cc-by)
- Funders
- National Science Foundation (8908154)
- James G. Boswell Foundation
- National Institutes of Health
- National Eye Institute (EY0 9278)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- NEMO gene, serine/threonine kinase
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Cloning, Molecular, Drosophila, Eye, Female, Male, Molecular Sequence Data, Mutation, Suppression, Genetic, Gene Expression, Genes, Insect, Protein Serine-Threonine Kinases, Sequence Homology, Amino Acid, Sequence Analysis, DNA, Photoreceptor Cells, Invertebrate, Mitogen-Activated Protein Kinases, Drosophila Proteins
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