Cited by 339Developmental Biology and Gene RegulationAxon Guidance and Neuronal SignalingNeurobiology and Insect Physiology Research

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Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene

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Choi, Kwang-Wook, Benzer, Seymour·1994·Cell

DOI 10.1016/0092-8674(94)90579-7

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Abstract

The Drosophila eye consists of a reiterative hexagonal array of photoreceptor cell clusters, the ommatidia. During normal morphogenesis, the clusters in the dorsal or ventral halves of the disc rotate 90 degrees in opposite directions, forming mirror images across a dorsoventral equator. In the mutant nemo (nmo), there is an initial turning of approximately 45 degrees, but further rotation is blocked. Genetic mosaic analysis indicates that the nmo gene acts upon each cluster as a whole; normal nmo function in one or more photoreceptor cells appears to be sufficient to induce full rotation. The nmo gene sequence encodes a serine/threonine protein kinase homolog, suggesting that the kinase is required to initiate the second step of rotation. In another mutant, roulette, excessive rotation through varying angles occurs in many ommatidia. This defect is suppressed by nmo, indicating that nmo acts upstream in a rotation-regulating pathway.

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Authors: Choi, K.-W., & Benzer, S.
Affiliations: California Institute of Technology (US)
ORCID: Choi, Kwang-Wook
Venue: Cell
Publisher: Elsevier BV
Published: 1994-07
Volume: 78
Issue: 1
Pages: 125-136
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/0092-8674(94)90579-7
OpenAlex: W1975803734
Cited by: 339
References: 49
Citations by year: 2025: 2 · 2024: 4 · 2023: 4 · 2022: 10 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 4 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 9 · 2012: 10
FWCI: 7.22
Type: journal article
Language: en
Open access: green
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Zenodo (CERN European Organization for Nuclear Research) (cc-by)
Funders: National Science Foundation (8908154)
James G. Boswell Foundation
National Institutes of Health
National Eye Institute (EY0 9278)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: NEMO gene, serine/threonine kinase
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, Cloning, Molecular, Drosophila, Eye, Female, Male, Molecular Sequence Data, Mutation, Suppression, Genetic, Gene Expression, Genes, Insect, Protein Serine-Threonine Kinases, Sequence Homology, Amino Acid, Sequence Analysis, DNA, Photoreceptor Cells, Invertebrate, Mitogen-Activated Protein Kinases, Drosophila Proteins

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Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene

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