The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
Open accessAbstract
The first cleavage of C. elegans is asymmetric, generating daughter cells with different sizes, cytoplasmic components, and fates. Mutations in the par-1 gene disrupt this asymmetry. We report here that par-1 encodes a putative Ser/Thr kinase with similarity to kinases from yeasts and mammals. Two strong alleles have mutations in the kinase domain, suggesting that kinase activity is essential for par-1 function. PAR-1 protein is localized to the posterior periphery of the zygote and is distributed in a polar fashion preceding the asymmetric divisions of the germline lineage. Because PAR-1 distribution in the germline correlates with the distribution of germline-specific P granules, it is possible that PAR-1 functions in germline development as well as in establishing embryonic polarity.
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Metadata
- Authors
- Guo, S., & Kemphues, K. J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1995-05
- Volume
- 81
- Issue
- 4
- Pages
- 611-620
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2149871164
- Cited by
- 1,122
- References
- 42
- FWCI
- 13.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. https://app.cochat.ai/papers/10.1016/0092-8674(95)90082-9
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- Guo, S., & Kemphues, K. J. (1995). par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell. https://doi.org/10.1016/0092-8674(95)90082-9
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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