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REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons

Chong, Jayhong A, Tapia-Ramirez, José, Kim, Sandra, Toledo-Aral, Juan J, Zheng, Yingcong, Boutros, Michael C, Altshuller, Yelena M, Frohman, Michael A, Kraner, Susan D, Mandel, Gail·1995·Cell
DOI 10.1016/0092-8674(95)90298-8
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Abstract

Expression of the type II voltage-dependent sodium channel gene is restricted to neurons by a silencer element active in nonneuronal cells. We have cloned cDNA coding for a transcription factor (REST) that binds to this silencer element. Expression of a recombinant REST protein confers the ability to silence type II reporter genes in neuronal cell types lacking the native REST protein, whereas expression of a dominant negative form of REST in nonneuronal cells relieves silencing mediated by the native protein. REST transcripts in developing mouse embryos are detected ubiquitously outside of the nervous system. We propose that expression of the type II sodium channel gene in neurons reflects a default pathway that is blocked in nonneuronal cells by the presence of REST.

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Metadata

Authors
Chong, J. A., Tapia-Ramirez, J., Kim, S., Toledo-Aral, J. J., Zheng, Y., Boutros, M. C., Altshuller, Y. M., Frohman, M. A., Kraner, S. D., & Mandel, G.
Venue
Cell
Publisher
Elsevier BV
Published
1995-03
Volume
80
Issue
6
Pages
949-957
ISSN
0092-8674
DOI
10.1016/0092-8674(95)90298-8
Cited by
967
References
1
Language
en
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