The synapsins: Key actors of synapse function and plasticity

Cesca, F.; Baldelli, P.; Valtorta, F.; Benfenati, F.

doi:10.1016/j.pneurobio.2010.04.006

Cited by 654Neuroscience and Neuropharmacology ResearchCellular transport and secretionGenetics and Neurodevelopmental Disorders

The synapsins: Key actors of synapse function and plasticity

Cesca, F., Baldelli, P., Valtorta, F., Benfenati, F.·2010·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2010.04.006

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Abstract

The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in invertebrate and vertebrate organisms. Their best-characterised function is to modulate neurotransmitter release at the pre-synaptic terminal, by reversibly tethering synaptic vesicles (SVs) to the actin cytoskeleton. However, many recent data have suggested novel functions for synapsins in other aspects of the pre-synaptic physiology, such as SV docking, fusion and recycling. Synapsin activity is tightly regulated by several protein kinases and phosphatases, which modulate the association of synapsins to SVs as well as their interaction with actin filaments and other synaptic proteins. In this context, synapsins act as a link between extracellular stimuli and the intracellular signalling events activated upon neuronal stimulation. Genetic manipulation of synapsins in various in vivo models has revealed that, although not essential for the basic development and functioning of neuronal networks, these proteins are extremely important in the fine-tuning of neuronal plasticity, as shown by the epileptic phenotype and behavioural abnormalities characterising mouse lines lacking one or more synapsin isoforms. In this review, we summarise the current knowledge about how the various members of the synapsin family are involved in the modulation of the pre-synaptic physiology. We give a comprehensive description of the molecular basis of synapsin function, as well as an overview of the more recent evidence linking mutations in the synapsin proteins to the onset of severe central nervous system diseases such as epilepsy and schizophrenia.

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Synapsins are critical in synapse function and plasticity.
“These synapsins are critical in synapse function and plasticity.166”
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Opposing Changes in Phosphorylation of Specific Sites in Synapsin I During Ca2+-Dependent Glutamate Release in Isolated Nerve Terminals
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Identification of a functional silencer element involved in neuron-specific expression of the synapsin I gene.
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Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I.
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Deficiency in Protein l-Isoaspartyl Methyltransferase Results in a Fatal Progressive Epilepsy
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Synapsin I is a microtubule-bundling protein
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The Evolutionary Pressure to Inactivate
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Distinct Roles of Synapsin I and Synapsin II during Neuronal Development
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In Vivo Modulation of O-GlcNAc Levels Regulates Hippocampal Synaptic Plasticity through Interplay with Phosphorylation
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Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON
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Opposite Changes in Glutamatergic and GABAergic Transmission Underlie the Diffuse Hyperexcitability of Synapsin I–Deficient Cortical Networks
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Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus
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Retinal Ganglion Cells
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Using the Atomic Force Microscope to Study the Interaction between Two Solid Supported Lipid Bilayers and the Influence of Synapsin I
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Intersectin Is a Negative Regulator of Dynamin Recruitment to the Synaptic Endocytic Zone in the Central Synapse
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Synapsin Is a Novel Rab3 Effector Protein on Small Synaptic Vesicles
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Authors: Cesca, F., Baldelli, P., Valtorta, F., & Benfenati, F.
Affiliations: Italian Institute of Technology (IT)
Vita-Salute San Raffaele University (IT)
Corresponding author: Benfenati, F.
ORCID: Cesca, F.
Baldelli, P.
Valtorta, F.
Benfenati, F.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2010-08
Volume: 91
Issue: 4
Pages: 313-348
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2010.04.006
OpenAlex: W2142790764
Cited by: 654
References: 375
Citations by year: 2026: 35 · 2025: 52 · 2024: 39 · 2023: 34 · 2022: 50 · 2021: 39 · 2020: 38 · 2019: 41 · 2018: 45 · 2017: 44 · 2016: 37 · 2015: 34 · 2014: 36 · 2013: 49 · 2012: 40
FWCI: 3.60
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Padua Research Archive (University of Padova) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: synapsin, synaptic vesicle tethering, neurotransmitter release, synaptic vesicle recycling, actin cytoskeleton, kinase regulation, synaptic plasticity, epilepsy, schizophrenia, central nervous system disorders
MeSH terms: Animals, Models, Biological, Neuronal Plasticity, Neurons, Phosphorylation, Protein Binding, Synapses, Synapsins

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The synapsins: Key actors of synapse function and plasticity

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