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Cited by 159

The DOI matches its Crossref record.

Preliminary report: effects of interleukin-1 on platelet counts

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Tewari, A., Starnes, H.F., Buhles, W.C.·1990·The Lancet
DOI 10.1016/0140-6736(90)92206-w
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Abstract

Recombinant human interleukin-1 beta was given in 5 daily intravenous infusions to ten patients with metastatic malignant disorders as part of an antineoplastic trial. All ten patients experienced transient increases in heart rate, low-grade fevers, and rigors. A neutrophil-dominated 100% rise in leucocyte counts occurred 4-8 h after treatment. Leucocyte counts returned to baseline levels within 24 h of interleukin-1 beta infusion. A 50% rise in platelets occurred in response to interleukin-1 beta; the increase in platelet counts was first noted 6 days after treatment began and was sustained for 24 days after treatment. Interleukin-1 beta may therefore be beneficial in the treatment of conditions of thrombocytopenia associated with haematological disorders and chemotherapy for malignant disorders.

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Metadata

Authors
Tewari, A., Starnes, H. F., & Buhles, W. C.
Venue
The Lancet
Publisher
Elsevier BV
Published
1990-09
Volume
336
Issue
8717
Pages
712-714
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/0140-6736(90)92206-w
OpenAlex
W1993194389
Cited by
159
References
0
FWCI
12.94
Type
journal article
Language
en
Status
Retracted
Open access
hybrid

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CoChat. (2026). Citation check: Preliminary report: effects of interleukin-1 on platelet counts. https://app.cochat.ai/papers/10.1016/0140-6736(90)92206-w
The paper
Tewari, A., Starnes, H. F., & Buhles, W. C. (1990). Preliminary report: effects of interleukin-1 on platelet counts. The Lancet. https://doi.org/10.1016/0140-6736(90)92206-w

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.