CoChat
Sign Up
Cited by 277Lipoproteins and Cardiovascular HealthCardiovascular Health and Risk FactorsSex and Gender in Healthcare

The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.

Relation between coronary risk and coronary mortality in women of the Renfrew and Paisley survey: comparison with men

Isles, C.G., Hole, D.J., Hawthorne, V.M., Lever, A.F.·1992·The Lancet
DOI 10.1016/0140-6736(92)90599-x
Open this paper in CoChat — free account

Abstract

Most epidemiological and intervention studies in patients with coronary artery disease have focused on men, the assumption being that such data can be extrapolated to women. However, there is little evidence to support this belief. We have completed a fifteen-year follow-up of 15,399 adults, including 8262 women, who lived in Renfrew and Paisley and were aged 45-64 years when screened between 1972 and 1976. We identified 490 deaths from coronary heart disease (CHD) in women and 878 in men. Women were more likely to have high cholesterol, to be obese, and to come from lower social classes than men, but they smoked less and had similar blood pressures. The relative risk--top to bottom quintile (95% Cl)--of cholesterol for coronary death after adjustment for all other risk markers was slightly greater in women (1.77 [1.45,2.16]) than in men (1.56 [1.32, 1.85]), but absolute and attributable risk were lower. Thus, women in the top quintile for cholesterol had lower coronary mortality (6.1 deaths per thousand patient years) than men in the bottom quintile (6.8 deaths per thousand patient years). Moreover, it was estimated that there would have been only 103 (21%) fewer CHD deaths in women, yet 211 (24%) fewer in men, if mortality had been the same for women and men in the lowest quintiles of cholesterol. Trends showing similar relative risks in these women, but lower absolute and attributable risks than in men, were present for smoking, diastolic blood pressure, and social class. There was no relation between obesity and coronary death after adjustment for other risks. Our results suggest that some other factors protect women against CHD. The potential for women to reduce their risk of CHD by changes in lifestyle may be less than for men.

Overview

Integrity signals

Registry

Crossref · 10.1016/0140-6736(92)90599-x

Cites

27 of 27 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Citations

Cites

Show all 26 references

Research works printed but not linked: 1

  1. Medical Research Council Working Party, 1985, MRC trial of treatment of mild hypertension: principal results, Br Med J, 2, 97

Cited by

Sorted by citations

Items 101–200 of 276

Related

See all

Metadata

Authors
Isles, C. G., Hole, D. J., Hawthorne, V. M., & Lever, A. F.
Affiliations
  • Dumfries and Galloway Royal Infirmary (GB)
  • Ruchill Hospital (GB)
  • University of Michigan (US)
  • Western Infirmary (GB)
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
1992-03
Volume
339
Issue
8795
Pages
702-706
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/0140-6736(92)90599-x
OpenAlex
W2045337129
Cited by
277
References
26
Citations by year
2025: 1 · 2024: 1 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 2 · 2015: 7 · 2014: 13 · 2013: 8 · 2012: 7
FWCI
17.11
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
  • Deep Blue (University of Michigan) (acceptedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Keywords
coronary heart disease mortality, women, coronary risk factors, cholesterol, sex differences, attributable risk, social class, smoking, blood pressure, obesity, middle-aged adults
MeSH terms
Age Factors, Blood Pressure, Cholesterol, Coronary Disease, Female, Humans, Male, Middle Aged, Risk Factors, Scotland, Sex Factors, Smoking, Social Class, Body Mass Index

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review