Low-dose inhalational nitric oxide in persistent pulmonary hypertension of the newborn
Abstract
We studied the effects of inhaled nitric oxide (NO) in 9 newborn infants with severe persistent pulmonary hypertension (PPHN) who were candidates for extracorporeal membrane oxygenation treatment. With low doses of NO (10-20 ppm) all showed rapid improvement in oxygenation without reduction of systemic blood pressure. In 6 infants treated with inhaled NO for 24 h, clinical improvement was sustained at 6 ppm.
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Complex I inhibition appears to occur through S-nitrosylation of cysteine thiol residues.
“Complex I inhibition appears to occur through S-nitrosylation of cysteine thiol residues, although the exact details still need to be elucidated.152,153”
From Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care (2010) · cites this paper as [152]
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- Authors
- KINSELLA, J.
- Affiliations
- University of Colorado Denver (US)
- Corresponding author
- KINSELLA, J
- ORCID
- KINSELLA, J
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1992-10
- Volume
- 340
- Issue
- 8823
- Pages
- 819-820
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2140036859
- Cited by
- 730
- References
- 0
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 16
- FWCI
- 79.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K08HL001932, HL46481, HL41012, HL-01932, P50HL046481)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Pulmonary Hypertension Research and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Keywords
- inhaled nitric oxide, persistent pulmonary hypertension of the newborn, oxygenation, systemic blood pressure, extracorporeal membrane oxygenation, neonatal respiratory failure
- MeSH terms
- Administration, Inhalation, Blood Pressure, Carbon Dioxide, Humans, Infant, Newborn, Methemoglobin, Nitric Oxide, Oxygen, Persistent Fetal Circulation Syndrome, Extracorporeal Membrane Oxygenation
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