Cited by 903Nitric Oxide and Endothelin EffectsAsthma and respiratory diseasesRedox biology and oxidative stress

Nitric oxide in health and disease of the respiratory system

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Ricciardolo, Fabio L. M., Sterk, Peter J., Gaston, Benjamin, Folkerts, Gert·2004·Physiological Reviews

Abstract

During the past decade a plethora of studies have unravelled the multiple roles of nitric oxide (NO) in airway physiology and pathophysiology. In the respiratory tract, NO is produced by a wide variety of cell types and is generated via oxidation of l-arginine that is catalyzed by the enzyme NO synthase (NOS). NOS exists in three distinct isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO derived from the constitutive isoforms of NOS (nNOS and eNOS) and other NO-adduct molecules (nitrosothiols) have been shown to be modulators of bronchomotor tone. On the other hand, NO derived from iNOS seems to be a proinflammatory mediator with immunomodulatory effects. The concentration of this molecule in exhaled air is abnormal in activated states of different inflammatory airway diseases, and its monitoring is potentially a major advance in the management of, e.g., asthma. Finally, the production of NO under oxidative stress conditions secondarily generates strong oxidizing agents (reactive nitrogen species) that may modulate the development of chronic inflammatory airway diseases and/or amplify the inflammatory response. The fundamental mechanisms driving the altered NO bioactivity under pathological conditions still need to be fully clarified, because their regulation provides a novel target in the prevention and treatment of chronic inflammatory diseases of the airways.

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Crossref · 10.1152/physrev.00034.2003

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  • NO activity derived from dietary nitrate and constitutive NOS might be protective against COPD largely through S-nitrosothiol-mediated mechanisms including inhibition of noncholinergic nonadrenergic nerve activity, bronchial smooth muscle relaxation, reduction of airway hyperresponsiveness, downregulation of proinflammatory T lymphocyte activity, and antimicrobial defense.

    “NO activity derived from dietary nitrate and constitutive NOS might be protective against COPD largely through the S-nitrosothiol-mediated mechanism including inhibition of the noncholinergic nonadrenergic nerve activity, bronchial smooth muscle relaxation, reduction of airway hyperresponsiveness, downregulation of the proinflammatory activity of T lymphocytes, and antimicrobial defense [127].”

    From NO-Rich Diet for Lifestyle-Related Diseases (2015) · cites this paper as [127]

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Authors
Ricciardolo, F. L. M., Sterk, P. J., Gaston, B., & Folkerts, G.
Affiliations
Utrecht University (NL)
Venue
Physiological Reviews
Published
2004-07
Volume
84
Issue
3
Pages
731-765
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
OpenAlex
W2157430977
Cited by
903
References
485
Citations by year
2026: 18 · 2025: 13 · 2024: 22 · 2023: 26 · 2022: 29 · 2021: 42 · 2020: 31 · 2019: 27 · 2018: 28 · 2017: 42 · 2016: 34 · 2015: 52 · 2014: 48 · 2013: 61 · 2012: 65
FWCI
5.09
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
nitric oxide, nitric oxide synthase, neuronal nitric oxide synthase, inducible nitric oxide synthase, endothelial nitric oxide synthase, S-nitrosothiols, bronchomotor tone, airway inflammation, asthma, exhaled nitric oxide, reactive nitrogen species, oxidative stress, chronic inflammatory airway diseases, immunomodulation
MeSH terms
Administration, Inhalation, Animals, Asthma, Health, Humans, Nitric Oxide, Respiration Disorders, Respiratory System, Respiratory Physiological Phenomena, Oxidative Stress, Exhalation

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