Proenkephalin and prodynorphin mRNA level in brain of rats with absence epilepsy
Abstract
An in situ hybridization method was used to estimate the proenkephalin (PENK) and prodynorphin (PDYN) mRNA levels in the brain of epileptic 6-month-old WAG/Rij rats in comparison with non-epileptic: 3-month-old WAG/Rij rats, 3-month-old ACI rats and 6-month-old ACI rats. The epileptic rats had a significantly higher level of PENK mRNA in the striatum as compared to non-epileptic controls. The PDYN mRNA level was significantly elevated only in the hippocampus of epileptic rats, whereas age- or strain-related changes in the striatal and cortical PDYN mRNA levels were found in both epileptic and non-epileptic rats. The changes in the biosynthetic activity of endogenous opioid peptide systems may be important for the occurrence of epileptic discharges in these animals.
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Several altered genes in P21-P60 that were detected in GWAS (e.g., Ddn, Slc17a6, Penk) imply direct association with major neuronal functions.
“several altered genes in P21-P60 that were detected in GWAS for example, Ddn58, Slc17a659 or Penk60 imply direct association with major neuronal functions.”
From Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction (2019) · cites this paper as [60]
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Bhattacherjee, A., Djekidel, M. N., Chen, R., Chen, W., Tuesta, L. M., & Zhang, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-12054-3 · Cited by 174 · see citing works
- Authors
- Lasoń, W., Przewłocka, B., Van Luijtelaar, G., & Coenen, A.
- Affiliations
- Maj Institute of Pharmacology (PL)
- Corresponding author
- Przewłocka, B.
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 27
- Issue
- 6
- Pages
- 343-347
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2045340672
- Cited by
- 26
- References
- 15
- Citations by year
- 2019: 1 · 2016: 1 · 2013: 1 · 2012: 3
- FWCI
- 0.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- proenkephalin, prodynorphin, mRNA expression, absence epilepsy, WAG/Rij rats, striatum, hippocampus, endogenous opioids, epileptic discharges, age-related changes, ACI rats
- MeSH terms
- Aging, Animals, Brain, Cerebral Cortex, Corpus Striatum, Enkephalins, Epilepsy, Absence, Hippocampus, Male, Protein Precursors, RNA, Messenger, In Situ Hybridization, Rats
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