Polymodal dose-response curve for oxytocin in the social recognition test
Abstract
Available data concerning the effect of oxytocin on memory are often inconsistent. In the present study it was found that oxytocin, intracerebroventricularly injected to adult male rats in a dose range of 1 fg-10 ng/rat immediately after a 5-minute encounter with a juvenile, significantly reduces the social investigation time of the adult rat towards the same juvenile during a second encounter (120 min later) with two peaks of activity, at 10 fg and 1 ng/rat. Larger doses of oxytocin were ineffective. The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin, injected 5 min before oxytocin by the same route and at the same doses, while being ineffective per se, completely abolished the memory-improving effect of a low dose of oxytocin (1 ng/rat) and, on the other hand, turned into memory-improving the effect of a high dose of oxytocin (500 ng/rat).
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ICV OT improved social recognition in male, but not female, rats.
“ICV OT improved social recognition in male (Benelli et al., 1995), but not in female (Engelmann et al., 1998) rats.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Benelli et al., 1995
Dose-dependent effects of OT on social behavior in animals and humans indicate that lower doses of OT may be more efficacious.
“Dose-dependent effects of OT on social behavior in animals (Benelli et al., 1995;Popik et al., 1992) and humans (Cardoso et al., 2013;Hall et al., 2012;Quintana et al., 2015b) that indicate that lower doses of OT may be more efficacious warrants further research.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Benelli et al., 1995
The data are in line with animal research that has associated a lower OT dose with stronger increases in social recognition.
“Furthermore, the data are in line with animal research that has associated a lower OT dose with stronger increases in social recognition (Benelli et al., 1995;Popik et al., 1992), which is pertinent given the crucial role of the amygdala in social cognition and behavior.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Benelli et al., 1995
Pre-clinical research demonstrates that lower doses of oxytocin may be more efficacious.
“despite pre-clinical research demonstrating that lower doses may be more efficacious.36, 37”
Research is increasingly pointing towards lower oxytocin doses being more (or at least equivalently) efficacious than higher doses.
“Research is increasingly pointing towards lower oxytocin doses being more (or at least equivalently) efficacious than higher doses.36, 37, 72, 73”
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References 28 · Cited by 128
- Authors
- Benelli, A., Bertolini, A., Poggioli, R., Menozzi, B., Basaglia, R., & Arletti, R.
- Affiliations
- University of Modena and Reggio Emilia (IT)
- Corresponding author
- Benelli, A
- Venue
- Neuropeptides
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 28
- Issue
- 4
- Pages
- 251-255
- ISSN
- 0143-4179 (ISSN-L)
- OpenAlex
- W2021232354
- Cited by
- 128
- References
- 28
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 6 · 2017: 14 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 7 · 2012: 4
- FWCI
- 2.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuropeptides (publishedVersion)
- PubMed (publishedVersion)
- IRIS UNIMORE (University of Modena and Reggio Emilia) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, social recognition memory, dose-response relationship, intracerebroventricular administration, memory enhancement, rats
- MeSH terms
- Animals, Behavior, Animal, Dose-Response Relationship, Drug, Injections, Intraventricular, Male, Memory, Short-Term, Oxytocin, Social Behavior, Vasotocin, Rats, Wistar, Rats
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