CD14 and other recognition molecules for lipopolysaccharide: A review
Abstract
Lipopolysaccharide (LPS) or endotoxin elicits a broad, non-specific cascade of events in vivo, resulting in secretion of a variety of potent mediators and cytokines produced primarily by activated macrophages and monocytes. The overproduction of these effector molecules, such as interleukin-1 and tumor necrosis factor-alpha, contributes to the pathophysiology of endotoxic shock. Cellular recognition of LPS involves several different molecules, including cluster of differentiation antigen CD14. A thorough understanding of the interaction of LPS with cells of the immune system is necessary before effective preventative or therapeutic measures can be designed to limit the host response to endotoxin. This review discusses the role of CD14 and other LPS-recognition molecules in LPS-mediated macrophage activation.
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LPS triggers massive inflammatory responses caused mainly by mitochondrial abnormalities.
“it is already well established that LPS, the bacterial endotoxin par excellence, triggers massive inflammatory responses caused mainly by mitochondrial abnormalities [39].”
From Effects of Mangiferin on LPS-Induced Inflammation and SARS-CoV-2 Viral Adsorption in Human Lung Cells (2022) · cites this paper as [39]
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Tomás-Camardiel, M., Rite, I., Herrera, A. J., de Pablos, R. M., Cano, J., Machado, A., & Venero, J. L. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.01.010 · Cited by 203 · see citing works
de Pablos, R. M., Herrera, A. J., Espinosa-Oliva, A. M., Sarmiento, M., Muñoz, M. F., Machado, A., & Venero, J. L. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-34 · Cited by 201 · see citing works
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“Indeed, it is already well established that LPS, the bacterial endotoxin par excellence, triggers massive inflammatory responses caused mainly by mitochondrial abnormalities [39].”
Background
- Authors
- Kielian, T. L., & Blecha, F.
- Affiliations
- Kansas State University (US)
- Corresponding author
- Blecha, Frank
- ORCID
- Kielian, Tammy L.
- Venue
- Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 29
- Issue
- 3
- Pages
- 187-205
- ISSN
- 0162-3109 (ISSN-L)
- OpenAlex
- W2088895956
- Cited by
- 152
- References
- 0
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 7 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 3 · 2012: 1
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- lipopolysaccharide, endotoxin, CD14, macrophage activation, endotoxic shock, interleukin-1, TNF-α, monocytes
- MeSH terms
- Lipopolysaccharide-Binding Protein, Acute-Phase Proteins, Carrier Proteins, Lipopolysaccharides, Macrophage Activation, Membrane Glycoproteins, Monocytes, Receptors, Immunologic, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Cytokines, Models, Immunological, CD18 Antigens, Lipopolysaccharide Receptors
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