Cited by 607Liver physiology and pathologyDrug-Induced Hepatotoxicity and ProtectionOrgan Transplantation Techniques and Outcomes

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Metabolic zonation of the liver: Regulation and implications for liver function

Gebhardt, Rolf·1992·Pharmacology & Therapeutics

DOI 10.1016/0163-7258(92)90055-5

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Abstract

Liver parenchyma shows a remarkable heterogeneity of the hepatocytes along the porto-central axis with respect to ultrastructure and enzyme activities resulting in different cellular functions within different zones of the liver lobuli. According to the concept of metabolic zonation, the spatial organization of the various metabolic pathways and functions forms the basis for the efficient adaptation of liver metabolism to the different nutritional requirements of the whole organism in different metabolic states. The present review summarizes current knowledge about this heterogeneity, its development and determination, as well as about its significance for the understanding of all aspects of liver function and pathology, especially of intermediary metabolism, biotransformation of drugs and zonal toxicity of hepatotoxins.

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Authors: Gebhardt, R.
Affiliations: University of Tübingen (DE)
Corresponding author: Gebhardt, Rolf
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 1992-01
Volume: 53
Issue: 3
Pages: 275-354
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/0163-7258(92)90055-5
OpenAlex: W2061717797
Cited by: 607
References: 880
Citations by year: 2026: 17 · 2025: 23 · 2024: 16 · 2023: 30 · 2022: 22 · 2021: 31 · 2020: 33 · 2019: 30 · 2018: 29 · 2017: 19 · 2016: 18 · 2015: 15 · 2014: 19 · 2013: 21 · 2012: 15
FWCI: 3.78
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords: metabolic zonation, liver lobule, hepatocyte heterogeneity, intermediary metabolism, drug metabolism, hepatotoxins, liver function, liver pathology
MeSH terms: Animals, Humans, Liver

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Metabolic zonation of the liver: Regulation and implications for liver function

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