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Cited by 607Liver physiology and pathologyDrug-Induced Hepatotoxicity and ProtectionOrgan Transplantation Techniques and Outcomes

The DOI matches its Crossref record; 854 of the 880 references it cites were found in a registry or an index.

Metabolic zonation of the liver: Regulation and implications for liver function

Gebhardt, Rolf·1992·Pharmacology & Therapeutics
DOI 10.1016/0163-7258(92)90055-5
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Abstract

Liver parenchyma shows a remarkable heterogeneity of the hepatocytes along the porto-central axis with respect to ultrastructure and enzyme activities resulting in different cellular functions within different zones of the liver lobuli. According to the concept of metabolic zonation, the spatial organization of the various metabolic pathways and functions forms the basis for the efficient adaptation of liver metabolism to the different nutritional requirements of the whole organism in different metabolic states. The present review summarizes current knowledge about this heterogeneity, its development and determination, as well as about its significance for the understanding of all aspects of liver function and pathology, especially of intermediary metabolism, biotransformation of drugs and zonal toxicity of hepatotoxins.

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Citations

Cites

Research works printed but not linked: 39

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Metadata

Authors
Gebhardt, R.
Affiliations
University of Tübingen (DE)
Corresponding author
Gebhardt, Rolf
Venue
Pharmacology & Therapeutics
Publisher
Elsevier BV
Published
1992-01
Volume
53
Issue
3
Pages
275-354
ISSN
0163-7258 (ISSN-L)
DOI
10.1016/0163-7258(92)90055-5
OpenAlex
W2061717797
Cited by
607
References
880
Citations by year
2026: 17 · 2025: 23 · 2024: 16 · 2023: 30 · 2022: 22 · 2021: 31 · 2020: 33 · 2019: 30 · 2018: 29 · 2017: 19 · 2016: 18 · 2015: 15 · 2014: 19 · 2013: 21 · 2012: 15
FWCI
3.78
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pharmacology & Therapeutics (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
Keywords
metabolic zonation, liver lobule, hepatocyte heterogeneity, intermediary metabolism, drug metabolism, hepatotoxins, liver function, liver pathology
MeSH terms
Animals, Humans, Liver

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