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Cited by 21Sleep and Wakefulness ResearchTreatment of Major DepressionSleep and related disorders

The DOI matches its Crossref record.

Slow wave sleep and 5-HT2 receptor sensitivity during maintenance tricyclic antidepressant treatment

Sharpley, A.L., Gregory, C.A., Solomon, R.A., Cowen, P.J.·1990·Journal of Affective Disorders
DOI 10.1016/0165-0327(90)90105-h
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Abstract

The 5-HT2 receptor antagonist cyproheptadine significantly increased slow wave sleep in 12 healthy control subjects but not in 12 patients with a history of major depression, maintained on tricyclic antidepressant treatment. Cyproheptadine produced a similar reduction in REM sleep in both groups of subjects. The results are consistent with the hypothesis that tricyclic antidepressant treatment alters brain 5-HT2 receptor sensitivity, but a primary abnormality in slow wave sleep regulation in depressed patients cannot be excluded.

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Crossref · 10.1016/0165-0327(90)90105-h

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  • The 5-HT2 receptor site has been implicated in the regulation of sleep.

    “The 5-HT 2 receptor site has been implicated in the regulation of sleep, thus providing a compelling rationale to compare effects of the SARIs to those pro-duced by the SSRIs with respect to sleep physiology [Idzikowski et al., 1989;Sharpley et al., 1990].”

    From Depression, sleep physiology, and antidepressant drugs (2001) · cites this paper as Sharpley et al., 1990

Citations

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Research works printed but not linked: 23

  1. Chen, 1979, Sleep, depression and antidepressants, Br. J. Psychiatry, 135, 385, 10.1192/bjp.135.5.385 · DOI
  2. Cowen, 1987, Platelet 5-HT receptor binding during depressive illness and tricyclic antidepressant treatment, J. Affect. Disord., 13, 45, 10.1016/0165-0327(87)90072-3 · DOI
  3. Farde, 1988, Central D2-dopamine receptor occupancy in schizophrenic patients treated with antipsychotic drugs, Arch. Gen. Psychiatry, 45, 71, 10.1001/archpsyc.1988.01800250087012 · DOI
  4. Friston, 1989, Lithium increases slow wave sleep: possible mediation by brain 5-HT2 receptors?, Psychopharmacology, 98, 139, 10.1007/BF00442020 · DOI
  5. Gillin, 1979, Successful separation of depressed, normal and insomniac subjects by EEG sleep data, Arch. Gen. Psychiatry, 36, 85, 10.1001/archpsyc.1979.01780010091010 · DOI
  6. Goodwin, 1984, 5-HT2 receptor characteristics in frontal cortex and 5-HT2 receptor-mediated head-twitch behaviour following antidepressant treatment to mice, Br. J. Pharmacol., 83, 235, 10.1111/j.1476-5381.1984.tb10140.x · DOI
  7. Hall, 1981, Effects of antidepressant drugs on different receptors in the brain, Eur. J. Pharmacol., 70, 393, 10.1016/0014-2999(81)90172-2 · DOI
  8. Hauri, 1974, Sleep of depressed patients in remission, Arch. Gen. Psychiatry, 31, 386, 10.1001/archpsyc.1974.01760150090013 · DOI
  9. Idzikowski, 1987, A dose-response study of the effects of ritanserin on slow wave sleep, Sleep Res., 16, 93
  10. Idzikowski, 1986, 5-Hydroxytryptamine2 antagonist increases human slow wave sleep, Brain Res., 378, 164, 10.1016/0006-8993(86)90299-4 · DOI
  11. Kupfer, 1976, EEG sleep changes as predictors in depression, Am. J. Psychiatry, 133, 622, 10.1176/ajp.133.6.622 · DOI
  12. Kupfer, 1988, Electroencephalographic sleep profiles in recurrent depression. A longitudinal investigation, Arch. Gen. Psychiatry, 45, 678, 10.1001/archpsyc.1988.01800310088011 · DOI
  13. Leysen, 1981, Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors, Life Sci., 28, 1115, 10.1016/0024-3205(81)90747-5 · DOI
  14. Peroutka, 1980, Long-term antidepressant treatment decreases spiroperidol-labelled serotonin receptor binding, Science, 210, 88, 10.1126/science.6251550 · DOI
  15. Peroutka, 1981, Two distinct serotonin receptors with different physiological functions, Science, 212, 827, 10.1126/science.7221567 · DOI
  16. Reynolds, 1987, Sleep research in affective illness: state of the art circa 1987, Sleep, 10, 199, 10.1093/sleep/10.3.199 · DOI
  17. Rush, 1986, Polysomnographic findings in recently drug-free and clinically remitted depressed patients, Arch. Gen. Psychiatry, 43, 878, 10.1001/archpsyc.1986.01800090068009 · DOI
  18. Sharpley, 1988, Evaluation of first night effect using ambulatory monitoring and automatic sleep stage analysis, Sleep, 11, 273, 10.1093/sleep/11.3.273 · DOI
  19. Sharpley, 1990, Dose-related effects of 5-HT2 receptor antagonists in humans, Psychopharmacology, 10.1007/BF02244239 · DOI
  20. Solomon, 1989, Increased slow wave sleep with 5-HT2 receptor antagonists: detection by ambulatory EEG recording and automatic sleep stage analysis, J. Psychopharmacol., 3, 125, 10.1177/026988118900300301 · DOI
  21. Sovner, 1983, Anorgasmia associated with imipramine but not desipramine: a case report, J. Clin. Psychiatry, 44, 345
  22. Specchio, 1976, Effetti della ciproeptadina sul sonno ell'uomo normale, Boll. Soc. It. Biol. Sper., LII, 1789
  23. Wander, 1986, Antagonism by antidepressants of serotonin S1 and serotonin S2 receptors of normal human brain in vitro, Eur. J. Pharmacol., 132, 115, 10.1016/0014-2999(86)90596-0 · DOI

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Metadata

Authors
Sharpley, A. L., Gregory, C. A., Solomon, R. A., & Cowen, P. J.
Affiliations
  • Littlemore Hospital (GB)
  • University of Oxford (GB)
Corresponding author
Sharpley, A.L.
ORCID
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
1990-08
Volume
19
Issue
4
Pages
273-277
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/0165-0327(90)90105-h
OpenAlex
W2015299723
Cited by
21
References
0
Citations by year
2017: 1 · 2013: 1
FWCI
1.07
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Wellcome Trust
  • Medical Research Council
  • Janssen Pharmaceuticals
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
slow-wave sleep, 5-HT2 receptor, cyproheptadine, tricyclic antidepressants, major depressive disorder, REM sleep, sleep regulation, receptor sensitivity
MeSH terms
Adult, Aged, Amitriptyline, Brain, Cyproheptadine, Depressive Disorder, Dothiepin, Double-Blind Method, Electroencephalography, Female, Humans, Male, Middle Aged, Reaction Time, Receptors, Serotonin, Sleep Stages, Sleep, REM

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