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Cited by 201

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Temperament predicts clomipramine and desipramine response in major depression

Joyce, Peter R., Mulder, Roger T., Cloninger, C.Robert·1994·Journal of Affective Disorders
DOI 10.1016/0165-0327(94)90149-x
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Abstract

Clinical predictors of drug response in major depression have been weak and inconsistent. Eighty-four patients suffering from a current major depressive episode completed a 6-week double-blind trial of either clomipramine or desipramine. Temperament, as measured by the Tridimensional Personality Questionnaire, accounted for 35% of the variance in treatment outcome, compared with less than 5% predicted by clinical variables. In the more severely depressed patients, temperament predicted nearly 50% of the variance in treatment outcome, which is the first time that such a substantial predictor of drug response has been identified. Within depressed women, temperament also predicted response to different antidepressant drugs. The potential importance of temperament, and the need for replication of these findings is discussed.

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Metadata

Authors
Joyce, P. R., Mulder, R. T., & Cloninger, C. R.
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
1994-01
Volume
30
Issue
1
Pages
35-46
ISSN
0165-0327 (ISSN-L)
DOI
10.1016/0165-0327(94)90149-x
OpenAlex
W2005004022
Cited by
201
References
7
FWCI
7.84
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Temperament predicts clomipramine and desipramine response in major depression. https://app.cochat.ai/papers/10.1016/0165-0327(94)90149-x
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Joyce, P. R., Mulder, R. T., & Cloninger, C. R. (1994). Temperament predicts clomipramine and desipramine response in major depression. Journal of Affective Disorders. https://doi.org/10.1016/0165-0327(94)90149-x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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