Oxygen-dependent and oxygen-independent mechanisms of microbicidal activity of neutrophils
Abstract
The essential role of the phagocyte in host defense against the enormous variety of microbial predators in our environment requires the availability of a "universal" weapon effective against most microbes, or an arsenal of different agents with specificity for different classes and species of microorganisms. Both polymorphonuclear leukocytes (PMN) and mononuclear phagocytes possess, or can produce, a wide range of antimicrobial agents providing these cells with an "overkill" capacity [1] that will usually bypass microbial defenses against a given antimicrobial device of the phagocyte. In this brief review we focus on the PMN because its antimicrobial systems have been analyzed most extensively. However, the killing mechanisms of mononuclear phagocytes and PMN are sufficiently similar to permit the insights gained from the study of the PMN to be applied to all phagocytes, including macrophages.
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Neutrophils use both O2-dependent and O2-independent mechanisms to kill micro-organisms.
“Ultimately, neutrophils use both O2-dependent and O2-independent mechanisms to kill micro-organisms [85].”
From The Role of Reactive Species on Innate Immunity (2022) · cites this paper as [85]
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- Authors
- Elsbach, P., & Weiss, J.
- Affiliations
- NYU Langone Health (US)
- ORCID
- Weiss, Jerrold
- Venue
- Immunology Letters
- Publisher
- Elsevier BV
- Published
- 1985-01
- Volume
- 11
- Issue
- 3-4
- Pages
- 159-163
- ISSN
- 0165-2478 (ISSN-L)
- OpenAlex
- W1991397191
- Cited by
- 52
- References
- 21
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2016: 1 · 2012: 1
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Immunology Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01am005472-24)
- U.S. Public Health Service
- National Institute of Allergy and Infectious Diseases (AI-18571)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- neutrophils, microbicidal activity, oxygen-dependent killing, polymorphonuclear leukocytes, phagocytes, antimicrobial mechanisms, mononuclear phagocytes, macrophages, host defense
- MeSH terms
- Animals, Blood Bactericidal Activity, Blood Proteins, Calcium, Cytotoxicity, Immunologic, Escherichia coli, Humans, Magnesium, Membrane Proteins, Neutrophils, Oxygen, Phagocytes, Rabbits, Antimicrobial Cationic Peptides, In Vitro Techniques
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