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Leukocyte cell-derived chemotaxin 2 regulates epithelial-mesenchymal transition and cancer stemness in hepatocellular carcinoma

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Dynamic change in expression of LECT2 during liver regeneration after partial hepatectomy in mice

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Common Molecular Targets of a Quinolone Based Bumped Kinase Inhibitor in Neospora caninum and Danio rerio

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New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study

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Expression, high-pressure refolding and purification of human leukocyte cell-derived chemotaxin 2 (LECT2)

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Prognostic value of LECT2 and relevance to immune infiltration in hepatocellular carcinoma

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Renal Amyloidosis

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A transmembrane C-type lectin receptor mediates LECT2 effects on head kidney-derived monocytes/macrophages in a teleost, Plecoglossus altivelis

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Updates on the role of leukocyte cell-derived chemotaxin-2 in inflammation regulation and immunomodulation

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Genomic organization, promoter characterization and expression analysis of the leukocyte cell-derived chemotaxin-2 gene in Epinephelus akaraa

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TGF-β1-Mediated Leukocyte Cell-Derived Chemotaxin 2 Is Associated With Liver Fibrosis in Biliary Atresia

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Tissue Specific Transcriptome Changes Upon Influenza A Virus Replication in the Duck

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Alleviation of lipopolysaccharide/ d -galactosamine-induced liver injury in leukocyte cell-derived chemotaxin 2 deficient mice

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Chicken mim-1 Protein, P33, Is a Heterophil Chemotactic Factor Present in Salmonella Enteritidis Immune Lymphokine

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Loss of LECT2 promotes ovarian cancer progression by inducing cancer invasiveness and facilitating an immunosuppressive environment

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Identification and expression analysis of the leukocyte cell-derived chemotaxin-2 (LECT2) gene in duck (Anas platyrhynchos)

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Leukemogenesis: Small differences in Myb have large effects

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Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy

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rP33 Activates Bacterial Killing by Chicken Peripheral Blood Heterophils

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LECT2 mediates antibacterial immune response induced by Nocardia seriolae infection in the northern snakehead

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Delving into the amyloidogenic core of human leukocyte chemotactic factor 2

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Expressed sequence tags (ESTs) based identification of genes and expression analysis of leukocyte cell-derived chemotaxin-2 (LECT2) from Epinephelus bruneus

Harikrishnan, R., Kim, J.-S., Kim, M., Balasundaram, C., & Heo, M. (2011) · Gene · doi:10.1016/j.gene.2011.08.029 · Cited by 8

LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH

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ALECT2 amyloidosis: a new type of systemic amyloid highly prevalent in the Hispanic population.

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Serum Leukocyte Cell-Derived Chemotaxin 2 (LECT2) Level Is Associated with Osteoporosis

Wang, Q., Xu, F., Chen, J., Xie, Y., Xu, S., & He, W. (2022) · Laboratory Medicine · doi:10.1093/labmed/lmac080 · Cited by 7

Other Systemic Forms of Amyloidosis

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Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans

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Novel ACE2 protein interactions relevant to COVID-19 predicted by evolutionary rate correlations

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Effect of a LECT2 on the immune response of peritoneal lecukocytes against Vibrio anguillarum in roughskin sculpin

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Cloning, characterization and expression of the LECT2 gene in grass carp

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Renal amyloidogenic leukocyte chemotactic factor 2 combined with IgA nephropathy: A case report

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Leukocyte cell-derived chemotaxin-2 and fibroblast growth factor 21 in alcohol-induced liver cirrhosis

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Leukocyte cell‐derived chemotaxin 2 correlates with pediatric non‐alcoholic fatty liver disease

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Plasma half-life and tissue distribution of leukocyte cell-derived chemotaxin 2 in mice

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Crystallization and preliminary X-ray analysis of human leukocyte cell-derived chemotaxin 2 (LECT2)

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M1-type polarized macrophage contributes to brain damage through CXCR3.2/CXCL11 pathways after RGNNV infection in grouper

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Role of LECT2 in exacerbating atopic dermatitis: insight from in vivo and in vitro models via NF-κB signaling pathway

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Hepatokine leukocyte cell‐derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction‐associated steatotic liver disease in the general population

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Serum leukocyte cell-derived chemotaxin 2 level is associated with atopic dermatitis patients

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Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core

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Elevated serum levels of leukocyte cell-derived chemotaxin 2 are associated with the prevalence of metabolic syndrome

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Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Chen, T., Qin, X., Jiang, J., & He, B. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1424246 · Cited by 5

LECT 2 Antagonizes FOXM1 Signaling via Inhibiting MET to Retard PDAC Progression

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Preparation of recombinant six-histidine-tagged human LECT2, a chemotactic protein to neutrophils, in Escherichia coli

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Amyloid

Gilbertson, J. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-7020-6864-5.00015-3 · Cited by 4

Multiple morphological phenotypes of monoclonal immunoglobulin disease on renal biopsy: Significance of treatment

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Regulation of katanin-P60 levels by LECT2 adjusts microtubular morphology

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Leukocyte cell-derived chemotaxin 2 (LECT2) regulates liver ischemia–reperfusion injury

Dong, M.-Q., Xie, Y., Tang, Z.-L., Zhao, X.-W., Lin, F.-Z., Zhang, G., Huang, Z.-H., Liu, Z., Yuan, L., Liu, F., et al. (2024) · Liver Research · doi:10.1016/j.livres.2024.09.004 · Cited by 3

Neurodevelopment: Three’s a Crowd, Four Is a Receptor Complex

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Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review

Liu, W., Wang, Q., Yeerlan, J., Yan, Y., Xu, L., Jia, C., Liu, X., & Zhang, L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1413466 · Cited by 3

Clinical Case Report: LECT2-Associated Adrenal Amyloidosis

Rauschecker, M., Cologna, S. M., Xekouki, P., Nilubol, N., Shamburek, R. D., Merino, M., Backlund, P. S., Yergey, A. L., Kebebew, E., Balow, J. E., et al. (2015) · AACE Clinical Case Reports · doi:10.4158/ep13443.cr · Cited by 3

Amyloid

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Plasma Leukocyte Cell-Derived Chemotaxin-2 as a Risk Factor of Sarcopenia: Korean Frailty and Aging Cohort Study

Roh, E., Hwang, S. Y., Kim, M., Won, C. W., & Choi, K. M. (2025) · Nutrients · doi:10.3390/nu17081342 · Cited by 1

Elevated LECT2 and PEDF in Pediatric MAFLD: Diagnostic Performance and Metabolic Correlations

Yang, L., Ni, H., Deng, M., Guo, T., Zhang, J., Sun, B., & Yang, W. (2025) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s555108 · Cited by 1

Structural polymorphism of ex-vivo ALECT2 amyloid fibrils revealed by cryo-EM

Afrin, S., Nguyen, B. A., Singh, V. P., Singh, P., Bassett, P. T., Pękała, M., Evers, B. M., López, C., Ahmed, Y., Li, L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71223-3 · Cited by 2

Contribution of Neutrophils to Aspergillus Infection.

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Letter to the Editor: 1H, 13C, 15N resonance assignments of the cytokine LECT2

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Ectopic Fat Accumulation in the Liver and Glucose Homeostasis

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Leukocyte Cell-Derived Chemotaxin 2 Amyloidosis (ALECT2)

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Effects of ammonia on the disease susceptibility of fish

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Beta-Catenin and the Survival of Hepatocytes

Nejak‐Bowen, K. N., & Monga, S. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-58106-4_6

The roles of leukocyte cell-derived chemotaxin 2 (LECT2) in hepatocellular carcinoma invasion and angiogenesis

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An amyloidosis-associated polymorphism does not alter LECT2 stability in vitroPreprint

Belonogov, L., Taylor, P. E., Wong, S., & Morgan, G. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.01.482540

Identification of a immune-related gene signature as a novel prognostic biomarker of cholangiocarcinomaPreprint

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LECT2 Amyloidosis and COVID-19: An Autopsy Case Report

Bluhm, L., Reisler, J., & Aronson, M. A. J. (2023) · Annals of Case Reports · doi:10.29011/2574-7754.101437

Primary membranous nephropathy combined with ALECT-2 renal amyloidosis：a case reportPreprint

Yang, Y., Yan, B., & Liu, X. (2023) · Research Square · doi:10.21203/rs.3.rs-3654855/v1

Renal Amyloidogenic Leukocyte Chemotactic Factor 2 Combined with Immunoglobulin A Nephropathy: 2 Case Reports and literature reviewPreprint

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The Unicorn of Nephrology: Leukocyte Chemotactic Factor 2 (ALECT2) Amyloidosis with Rare Associations - A Case Series

Singh, G., Damor, J. R., Agarwal, A., Malhotra, V., & Singh, A. P. (2025) · Indian Journal of Nephrology · doi:10.25259/ijn_112_2025

Assessing Liver Fibrosis in Chronic Hepatitis B Using LECT2: A Reliable New Biomarker

Shetty, A., & Lakshmi, S. (2025) · Journal of MedVerse Research & Practice · doi:10.65188/nurexus.1055

Rôle de LECT2 dans les maladies stéatosiques non alcooliques du foie

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Pathogenesis and kidney prognosis of renal amyloidosis

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Cryo-EM structures of ALECT2 filaments from human renal biopsies

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The V-Myb Oncogene

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Characterization of Leukocyte-Derived Neutrophil Chemotactic Factor-2 and Its Possible Roles in Neutrophil Infiltration in Allergic Inflammation in Rats

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The mechanism of neutrophil chemotactic factor production and the characteristics of the neutrophil chemotactic factor produced by the infiltrated leukocytes in allergic inflammation.

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