The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Strong association of the third hypervariable region of HLA-DRβ1 with autism
Abstract
We reported that the major histocompatibility complex (MHC) including the null allele of the C4B gene and the extended haplotype B44-C30-DR4 is associated with autism. We report now that the third hypervariable region (HVR-3) of certain DR beta 1 alleles have very strong association with autism. The HVR-3 of DR beta 1* 0401 or the shared HVR-3 alleles DR beta 1* 0404 and DR beta 1* 0404 and DR *0101, was expressed on extended haplotypes in 23 of 50 (46%) autistic subjects as compared to only 6 of 79 (7.5%) normal subjects. Another HVR-3 sequence, the DR beta 1* 0701 allele, was carried on extended haplotypes in 16 (32.0%) of the autistic subjects as compared to 8 (10.1%) of the normal subjects.
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“The hypervariable region 3 of DRB1*0401 has been associated with an increased relative risk for autism in children from Utah (Warren et al, 1996).”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Warren et al, 1996
Citations
Cites
Biology of the Autistic Syndromes
Coleman, M., & Cillberg, C. (1994) · Pediatric Physical Therapy · doi:10.1097/00001577-199400610-00026 · Cited by 468
Antibodies to Myelin Basic Protein in Children with Autistic Behavior
Singh, V. K., Warren, R. P., Odell, J. D., Warren, W. L., & Cole, P. (1993) · Brain, Behavior, and Immunity · doi:10.1006/brbi.1993.1010 · Cited by 274
Self-citationAncestral haplotypes: conserved population MHC haplotypes
Degli‐Esposti, M. A., Leaver, A. L., Christiansen, F., Witt, C. S., Abraham, L. J., & Dawkins, R. L. (1992) · Human Immunology · doi:10.1016/0198-8859(92)90023-g · Cited by 250
Immune abnormalities in patients with autism
Warren, R. P., Margaretten, N. C., Pace, N. C., & Foster, A. (1986) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01531729 · Cited by 207
Self-citationDepressed lymphocyte responsiveness in autistic children
Stubbs, E. G., Crawford, M. L., Burger, D. R., & Vandenbark, A. A. (1977) · Journal of Autism and Childhood Schizophrenia · doi:10.1007/bf01531114 · Cited by 202
Reduced Natural Killer Cell Activity in Autism
WARREN, R. P., FOSTER, A., & MARGARETTEN, N. C. (1987) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198705000-00008 · Cited by 190
Self-citationThe biology of the autistic syndromes
Naruse, H. (1993) · Brain and Development · doi:10.1016/0387-7604(93)90090-u · Cited by 161
Schaffer, F. M., Palermos, J., Zhu, Z. B., Barger, B. O., Cooper, M. D., & Volanakis, J. E. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.20.8015 · Cited by 157
Abnormal immune response to brain tissue antigen in the syndrome of autism
Weizman, A., Weizman, R., Szekely, G. A., Wijsenbeek, H., & Livni, E. (1982) · American Journal of Psychiatry · doi:10.1176/ajp.139.11.1462 · Cited by 136
Volanakis, J. E., Zhu, Z. B., Schaffer, F. M., Macon, K. J., Palermos, J., Barger, B. O., Go, R. C. P., Campbell, R. D., Schroeder, H. W., & Cooper, M. D. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115797 · Cited by 126
Research works printed but not linked: 1
- Plioplys, 1994, Immunoglobulin reactivity in autism and Rett's syndrome, Develop. Brain Dys., 7, 12
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The Epidemiology of Autism Spectrum Disorders
Newschaffer, C. J., Croen, L. A., Daniels, J., Giarelli, E., Grether, J. K., Levy, S. E., Mandell, D. S., Miller, L. A., Pinto-Martin, J., Reaven, J., et al. (2007) · Annual Review of Public Health · doi:10.1146/annurev.publhealth.28.021406.144007 · Cited by 1,228
Microglial Activation in Young Adults With Autism Spectrum Disorder
Suzuki, K., Sugihara, G., Ouchi, Y., Nakamura, K., Futatsubashi, M., Takebayashi, K., Yoshihara, Y., Omata, K., Matsumoto, K., Tsuchiya, K. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.272 · Cited by 523
The Role of the Immune System in Autism Spectrum Disorder
Meltzer, A., & Van de Water, J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.158 · Cited by 533
Belmonte, M. K., Cook, E. H., Anderson, G. M., Rubenstein, J. L. R., Greenough, W. T., Beckel-Mitchener, A., Courchesne, E., Boulanger, L. M., Powell, S. B., Levitt, P. R., et al. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001499 · Cited by 442
Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders
Atladóttir, H. O., Pedersen, M. G., Thorsen, P., Mortensen, P. B., Deleuran, B., Eaton, W. W., & Parner, E. T. (2009) · Pediatrics · doi:10.1542/peds.2008-2445 · Cited by 404
Metadata
- Authors
- Warren, R. P., Odell, J. D., Warren, W. L., Burger, R. A., Maciulis, A., Daniels, W. W., & Torres, A. R.
- Affiliations
- Utah State University (US)
- Corresponding author
- Warren, Reed P.
- ORCID
- Torres, Anthony R.
- Venue
- Journal of Neuroimmunology
- Publisher
- Elsevier BV
- Published
- 1996-07
- Volume
- 67
- Issue
- 2
- Pages
- 97-102
- ISSN
- 0165-5728 (ISSN-L)
- OpenAlex
- W2070318406
- Cited by
- 130
- References
- 23
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 4 · 2015: 4 · 2014: 4 · 2013: 1 · 2012: 7
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neuroimmunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh042119-10)
- National Institute of Mental Health (MH-42119)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, HLA-DRB1, major histocompatibility complex, genetic association, extended haplotypes, HLA-DR4
- MeSH terms
- Alleles, Autistic Disorder, Chromosomes, Female, Haplotypes, Humans, Immunoglobulin Variable Region, Male, HLA-DR1 Antigen
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