Insulin and insulin-like growth factors in the CNS

Insulin receptors are widely distributed in the central nervous system of the rat

Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116

Cellular Localization of Somatomedin (Insulin-Like Growth Factor) Messenger RNA in the Human Fetus

Han, V. K. M., D’Ercole, A. J., & Lund, P. K. (1987) · Science · doi:10.1126/science.3563497 · Cited by 657

Somatomedin-C/insulin-like growth factor-I and insulin-like growth factor-II mRNAs in rat fetal and adult tissues.

Lund, P. K., Moats‐Staats, B. M., Hynes, M., Simmons, J. G., Jansen, M., D’Ercole, A. J., & Wyk, J. J. V. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)66903-0 · Cited by 532

Tissue Distribution of Insulin-Like Growth Factor I and II Messenger Ribonucleic Acid in the Adult Rat*

Murphy, L. J., Bell, G. I., & Friesen, H. G. (1987) · Endocrinology · doi:10.1210/endo-120-4-1279 · Cited by 418

Autoradiographic localization of insulin receptors in rat brain: Prominence in olfactory and limbic areas

Hill, J. M., Lesniak, M. A., Pert, C. B., & Roth, J. (1986) · Neuroscience · doi:10.1016/0306-4522(86)90082-5 · Cited by 413

Blood-brain barrier transcytosis of insulin in developing rabbits

Duffy, K. R., & Pardridge, W. M. (1987) · Brain Research · doi:10.1016/0006-8993(87)90236-8 · Cited by 358

Insulin In The Brain

Baskin, D. G., Figlewicz, D. P., Woods, S. C., Porte, D., & Dorsa, D. M. (1987) · Annual Review of Physiology · doi:10.1146/annurev.ph.49.030187.002003 · Cited by 344

Developmental regulation of insulin-like growth factor II mRNA in different rat tissues.

Brown, A. L., Graham, D. E., Nissley, S. P., Hill, D. J., Strain, A. J., & Rechler, M. M. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)69282-8 · Cited by 321

Receptor-Mediated Peptide Transport through the Blood-Brain Barrier*

Pardridge, W. M. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-3-314 · Cited by 319

ADVANCES IN METABOLIC DISORDERS

Jordan, A. (1965) · Journal of Clinical Pathology · doi:10.1136/jcp.18.5.692-d · Cited by 296

Insulin, Neuropeptide Y, and Food Intake

Schwartz, M. W., Figlewicz, D. P., Woods, S. C., Porte, D., & Baskin, D. G. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb26206.x · Cited by 59

Growth factors in Parkinson's disease

Unsicker, K. (1994) · Progress in Growth Factor Research · doi:10.1016/0955-2235(94)90018-3 · Cited by 58

Autonomic Dysfunction of the β-Cell and the Pathogenesis of Obesity

Lustig, R. H. (2003) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1021819318484 · Cited by 58

Newborn Basal Forebrain Lesions Disrupt Cortical Cytodifferentiation as Visualized by Rapid Golgi Staining

Höhmann, C. F., Kwiterovich, K. K., Oster‐Granite, M. L., & Coyle, J. T. (1991) · Cerebral Cortex · doi:10.1093/cercor/1.2.143 · Cited by 56

Entorhinal cortex lesion induces differential responses in [125I]insulin-like growth factor I, [125I]insulin-like growth factor II and [125I]insulin receptor binding sites in the rat hippocampal formation

Kar, S., Baccichet, A., Quirion, R., & Poirier, J. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90455-o · Cited by 58

Comparison of the Effects of Amitriptyline and Flunarizine on Weight Gain and Serum Leptin, C Peptide and Insulin Levels when used as Migraine Preventive Treatment

Berilgen, M., Bulut, S., Gönen, M., Tekataş, A., Dağ, E., & Mungen, B. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2005.00956.x · Cited by 57

Glucocorticoids decrease body weight and food intake and inhibit appetite regulatory peptide expression in the hypothalamus of rats

Liu, X., SHI, J.-H., Du, W.-H., Fan, Y., Hu, X., Zhang, C., Xu, H., Miao, Y.-J., Zhou, H., Xiang, P., et al. (2011) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2011.292 · Cited by 58

The insulin‐like growth factor I system in cerebellar degeneration

Torres‐Alemán, I., Barrios, V., Lledó, A., & Berciano, J. (1996) · Annals of Neurology · doi:10.1002/ana.410390310 · Cited by 56

Insulin influences astroglial morphology and glial fibrillary acidic protein (GFAP) expression in organotypic cultures

Toran‐Allerand, C. D., Bentham, W. D. L., Miranda, R. C., & Anderson, J. P. (1991) · Brain Research · doi:10.1016/0006-8993(91)90781-p · Cited by 56

Growth Factors in Gliomas Revisited

Hamel, W., & Westphal, M. (2000) · Acta Neurochirurgica · doi:10.1007/s007010050015 · Cited by 53

A C. elegans model to study human metabolic regulation

Hashmi, S., Wang, Y., Parhar, R. S., Collison, K. S., Conca, W., Al-Mohanna, F. A., & Gaugler, R. R. (2013) · Nutrition & Metabolism · doi:10.1186/1743-7075-10-31 · Cited by 53

Staying Slim with Insulin in Mind

Schwartz, M. W. (2000) · Science · doi:10.1126/science.289.5487.2066 · Cited by 52

The Effects of Centrally Administered Porcine Relaxin on Drinking Behaviour in Male and Female Rats

Thornton, S. N., & Fitzsimons, J. T. (1995) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1995.tb00743.x · Cited by 52

Various aspects of feeding behavior can be partially dissociated in the rat by the incentive properties of food and the physiological state.

Barbano, M. F., & Cador, M. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.5.1244 · Cited by 51

Molecular and biochemical trajectories from diabetes to Alzheimer’s disease: A critical appraisal

Sandhir, R., & Gupta, S. N. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i12.1223 · Cited by 49

Potential Neurotrophic Factors in the Mammalian Central Nervous System: Functional Significance in the Developing and Aging Brain

Araujo, D. M., Chabot, J., & Quirion, R. (1990) · International review of neurobiology · doi:10.1016/s0074-7742(08)60582-6 · Cited by 49

Stroke Neuroprotection: Oestrogen and Insulin‐Like Growth Factor ‐1 Interactions and the Role of Microglia

Sohrabji, F., & Williams, M. H. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12059 · Cited by 51

Feeding-related immunoreactive insulin changes in the PVN-VMH revealed by microdialysis

Orosco, M., Gerozissis, K., Rouch, C., & Nicolaı̈dis, S. (1995) · Brain Research · doi:10.1016/0006-8993(94)01347-k · Cited by 49

Insulin-like growth factor II promotes in vitro cholinergic development of mouse septal neurons: comparison with the effects of insulin-like growth factor I

Konishi, Y., Takahashi, K., Chui, D.-H., Rosenfeld, R. G., Himeno, M., & Tabira, T. (1994) · Brain Research · doi:10.1016/0006-8993(94)91048-0 · Cited by 48

Location of phosphotyrosine-containing proteins by immunocytochemistry in the rat forebrain corresponds to the distribution of the insulin receptor.

Moss, A., Unger, J. W., Moxley, R. T., & Livingston, J. N. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.12.4453 · Cited by 47

Brain neuropeptides: actions on central cardiovascular control mechanisms

Gardiner, S. M., & Bennett, T. (1989) · Brain Research Reviews · doi:10.1016/0165-0173(89)90010-6 · Cited by 45

Insulin Responses to a Fat Meal in Hypothalamic Microdialysates and Plasma

Gerozissis, K., Orosco, M., Rouch, C., & Nicolaı̈dis, S. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00195-9 · Cited by 46

Four-day hyperinsulinemia in euglycemic conditions alters local cerebral glucose utilization in specific brain nuclei of freely moving rats

Doyle, P., Cusin, I., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1995) · Brain Research · doi:10.1016/0006-8993(95)00402-c · Cited by 46

Systemic administration of kainic acid induces selective time dependent decrease in [125I]insulin-like growth factor I, [125I]insulin-like growth factor II and [125I]insulin receptor binding sites in adult rat hippocampal formation

Kar, S., Seto, D., Doré, S., Chabot, J. ‐., & Quirion, R. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00185-1 · Cited by 45

Release of Immunoreactive Insulin from Rat Brain Synaptosomes Under Depolarizing Conditions

Wei, L., Matsumoto, H., & Rhoads, D. E. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01219.x · Cited by 45

A Potential Role of Central Insulin in Learning and Memory Related to Feeding

Gerozissis, K., Rouch, C., Lemierre, S., Nicolaı̈dis, S., & Orosco, M. (2001) · Cellular and Molecular Neurobiology · doi:10.1023/a:1012606206116 · Cited by 45

Increase of extracellular insulin-like growth factor I (IGF-I) concentration following electrolytical lesion in rat hippocampus

Yamaguchi, F., Itano, T., Miyamoto, O., Janjua, N. A., Ohmoto, T., Hosokawa, K., & Hatase, O. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90278-2 · Cited by 45

Effect of calorie-protein supplementation on the cognitive recovery of patients with subacute stroke

Aquilani, R., Scocchi, M., Boschi, F., Viglio, S., Iadarola, P., Pastoris, O., & Verri, M. (2008) · Nutritional Neuroscience · doi:10.1179/147683008x301586 · Cited by 44

Truncation of IGF-I yields two mitogens for retinal Müller glial cells

Ikeda, T., Waldbillig, R. J., & Puro, D. G. (1995) · Brain Research · doi:10.1016/0006-8993(95)00473-4 · Cited by 44

Expression of IGF-II, IGFBP-2, -5, and -6 in Meningiomas with Different Brain Invasiveness

Nordqvist, A. S., & Mathiesen, T. I. (2002) · Journal of Neuro-Oncology · doi:10.1023/a:1015765613544 · Cited by 43

Effects of Age on Elements of Insulin-Signaling Pathway in Central Nervous System of Rats

Fernandes, M. L. D. L. A., Saad, M. J. A., & Velloso, L. A. (2001) · Endocrine · doi:10.1385/endo:16:3:227 · Cited by 42

P HYSIOLOGIC D ETERMINANTS OF THE A NOREXIA OF A GING : Insights from Animal Studies

Horwitz, B. A., Blanton, C. A., & McDonald, R. B. (2002) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.22.120301.071049 · Cited by 42

Insulin-like growth factor I (IGF-I) distribution in the tissue and extracellular compartment in different regions of rat brain

Yamaguchi, F., Itano, T., Mizobuchi, M., Miyamoto, O., Jangua, N. A., Matsui, H., Tokuda, M., Ohmoto, T., Hosokawa, K., & Hatase, O. (1990) · Brain Research · doi:10.1016/0006-8993(90)91361-j · Cited by 41

Basic fibroblast growth factor regulates the conversion of pro- luteinizing hormone-releasing hormone (Pro-LHRH) to LHRH in immortalized hypothalamic neurons

Wetsel, W. C., Hill, D. F., & Ojeda, S. R. (1996) · Endocrinology · doi:10.1210/endo.137.6.8641215 · Cited by 41

The effects of maternal diabetes on expression of insulin-like growth factor-1 and insulin receptors in male developing rat hippocampus

Hami, J., Sadr‐Nabavi, A., Sankian, M., Balali‐Mood, M., & Haghir, H. (2012) · Brain Structure and Function · doi:10.1007/s00429-011-0377-y · Cited by 40

Effect of cerebroventricular infusion of insulin and (or) glucose on hypothalamic expression of leptin receptor and pituitary secretion of LH in diet-restricted ewes☆

Daniel, J. A., Thomas, M. G., Hale, C. S., Simmons, J. M., & Keisler, D. H. (2000) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(99)00077-6 · Cited by 40

Insulin-like growth factor-I receptor densities in human frontal cortex and white matter during aging, in Alzheimer's disease, and in Huntington's disease

Keyser, J. D., Wilczak, N., & Goossens, A. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90670-x · Cited by 40

Genome-wide identification and comparative analysis of the TUBBY-like protein gene family in maize

Yulong, C., Wei, D., Baoming, S., Yang, Z., & Ma, Q. (2015) · Genes & Genomics · doi:10.1007/s13258-015-0338-6 · Cited by 39

Potential of progenitors from postnatal cerebellar neuroepithelium and white matter: lineage specified vs. multipotent fate

Milosevic, A., & Goldman, J. E. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.02.008 · Cited by 39

Insulin-like growth factor-I modulation of cerebellar cell populations is developmentally stage-dependent and mediated by specific intracellular pathways

Torres‐Alemán, I., Villalba, M., & Nieto‐Bona, M. P. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00367-9 · Cited by 39

Aspects of neural plasticity in the central nervous system—VII. Theoretical aspects of brain communication and computation☆

Agnati, L. F., Zoli, M., Pich, E. M., Benfenati, F., & Fuxé, K. (1990) · Neurochemistry International · doi:10.1016/0197-0186(90)90008-h · Cited by 39

Insulin-like growth factor I increases myelination and inhibits demyelination in cultured organotypic nerve tissue

Roth, G. A., Spada, V., Hamill, K., & Bornstein, M. B. (1995) · Developmental Brain Research · doi:10.1016/0165-3806(95)00088-u · Cited by 39

Developmental Regulation of Insulin-Like Growth Factor-I-Stimulated Glucose Transporter in Rat Brain Astrocytes*

Masters, B. A., Werner, H., Roberts, C. T., LeRoith, D., & Raizada, M. K. (1991) · Endocrinology · doi:10.1210/endo-128-5-2548 · Cited by 39

Stimulation of Immunoreactive Insulin Release by Glucose in Rat Brain Synaptosomes

Santos, M. S., Pereira, E. M., & Carvaho, A. P. (1999) · Neurochemical Research · doi:10.1023/a:1020971812098 · Cited by 38

Obesogenic phenotype of offspring of dams fed a high multivitamin diet is prevented by a post-weaning high multivitamin or high folate diet

Cho, C. E., Sánchez‐Hernández, D., Reza‐López, S. A., Huot, P. S. P., Kim, Y., & Anderson, G. H. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.210 · Cited by 38

Effect of Experimental Diabetes on the Catecholamine Metabolism in Rat Brain

Gupta, G., Azam, M., & Baquer, N. Z. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09282.x · Cited by 37

Insulin-like growth factors in central nervous system tumors

Glick, R. P., Lichtor, T., & Unterman, T. G. (1997) · Journal of Neuro-Oncology · doi:10.1023/a:1005876819455 · Cited by 36

Nerve growth factor increases the mitogenicity of certain growth factors for cultured human keratinocytes: A comparison with epidermal growth factor

Wilkinson, D. I., Theeuwes, M. J., & Farber, E. M. (1994) · Experimental Dermatology · doi:10.1111/j.1600-0625.1994.tb00283.x · Cited by 36

Neonatal repetitive maternal separation causes long-lasting alterations in various neurotrophic factor expression in the cerebral cortex of rats

Lee, K., Miki, T., YOKOYAMA, T., Ueki, M., Warita, K., Suzuki, S., Ohta, K., Wang, Z., Jamal, M., Yakura, T., et al. (2012) · Life Sciences · doi:10.1016/j.lfs.2012.01.021 · Cited by 37

Low Insulin-like Growth Factor-II Levels Predict Weight Gain in Normal Weight Subjects with Type 2 Diabetes

Heald, A. H., Kärvestedt, L., Anderson, S. G., McLaughlin, J., Knowles, A., Wong, L., Grill, V., Cruickshank, J. K., White, A. E., Gibson, M., et al. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.08.001 · Cited by 35

Denervation and hyperinnervation in the nervous system of diabetic animals. II. Monoaminergic and peptidergic alterations in the diabetic encephalopathy

Giulio, A. M. D., Tenconi, B., Croix, R. L., Mantegazza, P., Abbracchio, M. P., Cattabeni, F., & Gorio, A. (1989) · Journal of Neuroscience Research · doi:10.1002/jnr.490240304 · Cited by 35

Synthesis and neuroprotective activity of analogues of glycyl-l-prolyl-l-glutamic acid (GPE) modified at the α-carboxylic acid

Trotter, N. S., Brimble, M. A., Harris, P. W. R., Callis, D. J., & Sieg, F. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.10.005 · Cited by 34

Insulin‐like growth factor I is an afferent trophic signal that modulates calbindin‐28kD in adult Purkinje cells

Nieto‐Bona, M. P., Busiguina, S., & Torres‐Alemán, I. (1995) · Journal of Neuroscience Research · doi:10.1002/jnr.490420311 · Cited by 34

Brain Insulin Response to Feeding in the Rat Is Both Macronutrient and Area Specific

Gerozissis, K., Rouch, C., Nicolaı̈dis, S., & Orosco, M. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00061-x · Cited by 33

Insulin and insulin-like growth factors in central nervous system tumors

Glick, R. P., Unterman, T. G., der Woude, M. V., & Blaydes, L. Z. (1992) · Journal of neurosurgery · doi:10.3171/jns.1992.77.3.0445 · Cited by 33

Insulin binding in the hypothalamus of lean and genetically obese Zucker rats

Wilcox, B. J., Corp, E. S., Dorsa, D. M., Figlewicz, D. P., Greenwood, M. R. C., Woods, S. C., & Baskin, D. G. (1989) · Peptides · doi:10.1016/0196-9781(89)90008-9 · Cited by 32

Shared signaling pathways in Alzheimer’s and metabolic disease may point to new treatment approaches

Suresh, J., Khor, I. W., Kaur, P., Heng, H. L., Torta, F. T., Dawe, G. S., Tai, E. S., & Tolwinski, N. S. (2020) · FEBS Journal · doi:10.1111/febs.15540 · Cited by 34

Sex differences and left–right asymmetries in expression of insulin and insulin-like growth factor-1 receptors in developing rat hippocampus

Hami, J., Sadr‐Nabavi, A., Sankian, M., & Haghir, H. (2011) · Brain Structure and Function · doi:10.1007/s00429-011-0358-1 · Cited by 32

Potential interactions of zinc in the neuroendocrine-endocrine disturbances of diabetes mellitus type 2

Tallman, D. L., & Taylor, C. G. (1999) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y99-111 · Cited by 32

Trophic Actions of IGF-I, IGF-II and Insulin on Cholinergic and Dopaminergic Brain Neurons

Knüsel, B., & Hefti, F. F. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5949-4_31 · Cited by 32

Insulin-like growth factor I modulates voltage-dependent Ca2+ channels in neuronal cells

Kleppisch, T., Klinz, F., & Hescheler, J. (1992) · Brain Research · doi:10.1016/0006-8993(92)91709-n · Cited by 32

Interferon‐γ inhibits DNA synthesis and insulin‐like growth factor‐II expression in human neuroblastoma cells

Martin, D. M., Carlson, R. O., & Feldman, E. L. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490340502 · Cited by 32

Memory of Conditioned Taste Aversion Is Erased by Inhibition of PI3K in the Insular Cortex

Slouzkey, I., Rosenblum, K., & Maroun, M. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.20 · Cited by 30

Neurotrophic factors in neurodegenerative disorders: Model of parkinson’s disease

de Yébenes, J. G., & Mena, M. A. (2000) · Neurotoxicity Research · doi:10.1007/bf03033789 · Cited by 31

Growth factor treatment to overcome Alzheimer's dysfunctional signaling

Lauzon, M.-A., Daviau, A., Marcos, B., & Faucheux, N. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.02.018 · Cited by 30

Synthesis and secretion of insulin-like growth factor (IGF)-II and IGF binding protein-2 by cultivated brain meningeal cells

Ishikawa, K., Ohe, Y., & Tatemoto, K. (1995) · Brain Research · doi:10.1016/0006-8993(95)00798-u · Cited by 30

Radioimmunoassay of insulin-like growth factors in cyst fluid of central nervous system tumors

Glick, R. P., Unterman, T. G., & Hollis, R. (1991) · Journal of neurosurgery · doi:10.3171/jns.1991.74.6.0972 · Cited by 30

Beneficial Flavonoid in Foods and Anti-obesity Effect

Liu, J., Cao, J., Li, Y., & Guo, F. (2021) · Food Reviews International · doi:10.1080/87559129.2021.1923730 · Cited by 29

Central Nervous Effects of Leptin and Insulin on Hippocampal Leptin and Insulin Receptor Expression following a Learning Task in Wistar Rats

Paulus, K., Schulz, C., & Lehnert, H. (2005) · Neuropsychobiology · doi:10.1159/000084167 · Cited by 29

Differential Regulation of Leptin Receptor Expression by Insulin and Leptin in Neuroblastoma Cells

Hikita, M., Bujo, H., Hirayama, S., Takahashi, K., Morisaki, N., & Saitō, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2692 · Cited by 29

Soluble factors involved in glioma invasion

Mueller, M. M., Werbowetski‐Ogilvie, T. E., & Maestro, R. F. D. (2003) · Acta Neurochirurgica · doi:10.1007/s00701-003-0132-0 · Cited by 29

Dysregulation of energy homeostasis in mice overexpressing insulin-like growth factor-binding protein 6 in the brain

Bienvenu, G., Seurin, D., Bouc, Y. L., Even, P. C., Babajko, S., & Magnan, C. (2005) · Diabetologia · doi:10.1007/s00125-005-1767-6 · Cited by 28

Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression

Naidu, K. A., Tang, J., Naidu, K. A., Prockop, L. D., Nicosia, S. V., & Coppola, D. (2001) · Journal of Neuro-Oncology · doi:10.1023/a:1012545311054 · Cited by 28

Denervation and hyperinnervation in the nervous system of diabetic animals: III. Functional alterations of G proteins in diabetic encephalopathy

Abbracchio, M. P., Luca, M. D., Giulio, A. M. D., Cattabeni, F., Tenconi, B., & Gorio, A. (1989) · Journal of Neuroscience Research · doi:10.1002/jnr.490240409 · Cited by 28

Obesity, Metabolic Syndrome and Disorders of Energy Balance

Han, J. C., & Weiss, R. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-62520-3.00024-5 · Cited by 27

Synthesis and pharmacological evaluation of glycine-modified analogues of the neuroprotective agent glycyl-l-prolyl-l-glutamic acid (GPE)

Lai, M. Y. H., Brimble, M. A., Callis, D. J., Harris, P. W. R., Levi, M. S., & Sieg, F. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.10.004 · Cited by 27

Molecular mechanisms for generation of neural diversity and specificity: roles of polypeptide factors in development of postmitotic neurons

Yamamori, T. (1992) · Neuroscience Research · doi:10.1016/0168-0102(92)90064-j · Cited by 27

Gender Differences and Lateralization in the Distribution Pattern of Insulin-Like Growth Factor-1 Receptor in Developing Rat Hippocampus: An Immunohistochemical Study

Hami, J., Kheradmand, H., & Haghir, H. (2013) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-013-0005-x · Cited by 26

Mitogenically Uncoupled Insulin and IGF-I Receptors of Differentiated Human Neuroblastoma Cells Are Functional and Mediate Ligand-Induced Signals

Mattsson, M. E. K., Hammerling, U., Mohall, E., Hall, K. E., & Påhlman, S. (1990) · Growth Factors · doi:10.3109/08977199009078013 · Cited by 26

Involvement of protein kinase C and nitric oxide in the modulation by insulin-like growth factor-I of glutamate-induced GABA release in the cerebellum

Castro‐Alamancos, M. A., Arévalo, M., & Torres‐Alemán, I. (1996) · Neuroscience · doi:10.1016/0306-4522(95)00472-6 · Cited by 25

Appetite and Body Weight Regulation

Vasselli, J. R. (2012) · Wiley eBooks · doi:10.1002/9781394323142.ch8 · Cited by 25

Whole body hypothermia broadens the therapeutic window of intranasally administered IGF-1 in a neonatal rat model of cerebral hypoxia–ischemia

Lin, S., Rhodes, P. G., & Cai, Z. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.013 · Cited by 24

Growth promoting effects of IGF‐I on fetal hypothalamic cell lines under serum‐free culture conditions

Torres‐Alemán, I., Naftolin, F. N., & Robbins, R. J. (1989) · International Journal of Developmental Neuroscience · doi:10.1016/0736-5748(89)90069-5 · Cited by 24

Brain insulin response to feeding in the rat is both macronutrient and area specific

Gerozissis, K., Rouch, C., Nicolaı̈dis, S., & Orosco, M. (1998) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00158-9 · Cited by 24

The effect of insulin and insulin-like growth factor-1 on the expression of calretinin and calbindin D-28k in rat embryonic neurons in culture

Yamaguchi, T., Keino‐Masu, K., & Fukuda, J. (1995) · Neurochemistry International · doi:10.1016/0197-0186(94)00127-g · Cited by 24

The effects of induced type-I diabetes on developmental regulation of insulin & insulin like growth factor-1 (IGF-1) receptors in the cerebellum of rat neonates

Haghir, H., Rezaee, S. A., Sankian, M., Kheradmand, H., & Hami, J. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-013-9386-2 · Cited by 23

Specific Binding of Insulin to Membranes from Dendrodendritic Synaptosomes of Rat Olfactory Bulb

Matsumoto, H., & Rhoads, D. E. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb13321.x · Cited by 23

Growth and neurotrophic factors regulating development and maintenance of sympathetic preganglionic neurons

Schober, A., & Unsicker, K. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)05002-1 · Cited by 23

Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-l-prolyl-l-glutamic acid (GPE)

Brimble, M. A., Trotter, N. S., Harris, P. W. R., & Sieg, F. (2004) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2004.10.006 · Cited by 23

Presence and differential internalization of two distinct insulin-like growth factor receptors in rat hippocampal neurons

Doré, S., Kar, S., & Quirion, R. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00594-5 · Cited by 23

Neuropeptide Receptors and Astrocytes

Krisch, B., & Mentlein, R. (1994) · International review of cytology · doi:10.1016/s0074-7696(08)62407-9 · Cited by 22

Selective delivery of insulin into the brain: Intraolfactory absorption

Gizurarson, S. S., Thorvaldsson, T., Sigurdsson, P., & Gunnarsson, E. (1997) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(97)97185-4 · Cited by 22

Hypothalamic Monoamines and Insulin in Relation to Feeding in the Genetically Obese Zucker Rat as Revealed by Microdialysis

Orosco, M., Gerozissis, K., Rouch, C., Meile, M.-J., & Nicolaı̈dis, S. (1995) · Obesity Research · doi:10.1002/j.1550-8528.1995.tb00483.x · Cited by 22

Protein Phosphotyrosine in Mouse Brain: Developmental Changes and Regulation by Epidermal Growth Factor, Type I Insulin‐Like Growth Factor, and Insulin

Girault, J., Chamak, B., Bertuzzi, G., Tixier, H., Wang, J. K. T., Pang, D. T., & Greengard, P. (1992) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1992.tb09751.x · Cited by 22

Effect of Leptin on Hypothalamic Gene Expression in Calorie-Restricted Rats

Komatsu, T., Chiba, T., Yamaza, H., To, K., Toyama, H., Higami, Y., & Shimokawa, I. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.9.890 · Cited by 20

Alzheimer’s phenotypes induced by overexpression of human presenilin 2 mutant proteins stimulate significant changes in key factors of glucose metabolism

Lee, Y. J., Kim, J. E., Hwang, I. S., Kwak, M. H., Lee, J. H., Jung, Y. J., An, B. S., Kwon, H. S., Kim, B. C., KIM, S. J., et al. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1404 · Cited by 22

Hormones and the Cytoskeleton of Animals and Plants

LOOF, A. D., Broeck, J. V., & Janssen, I. (1996) · International review of cytology · doi:10.1016/s0074-7696(08)62505-x · Cited by 21

Growth Factors and Lymphokines: Modulators of Cholinergic Neuronal Activity

Quirion, R., Araujo, D. M., Lapchak, P. A., Seto, D., & Chabot, J. (1991) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/s0317167100032510 · Cited by 21

Reduction of insulin binding in the arcuate nucleus of the rat hypothalamus after 6-hydroxydopamine treatment

Wilcox, B. J., Matsumoto, A. M., Dorsa, D. M., & Baskin, D. G. (1989) · Brain Research · doi:10.1016/0006-8993(89)90308-9 · Cited by 21

Regulation of cerebroside sulfotransferase activity in cultured oligodendrocytes: Effect of growth factors and insulin

Fressinaud, C., Sarliève, L. L., & Labourdette, G. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041410327 · Cited by 21

Insulin-Like Growth Factor Receptors in the Brain

Baskin, D. G., Bohannon, N. J. V., & Figlewicz, D. P. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5380-5_19 · Cited by 5

Insulin and insulin-like growth fadors in the CN$

Baskin, D. G., Wilcox, B. J., & Dorsa, D. M. (1988)

Receptors for Insulin and Insulin Related Peptides in the CNS: Studies of Localization in Rat Brain

Hill, J. M., Lesniak, M. A., Rojeshi, M., Pert, C. B., & Roth, J. (1987) · Springer eBooks · doi:10.1007/978-1-4684-5380-5_20 · Cited by 4

Regulation and Physiological Function of Insulin-Like Growth Factors in the Central Nervous System

Lauterio, T. J. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5949-4_37 · Cited by 7

Analysis of Insulin and Insulin-Like Growth Factor-I Receptors in Neural Tissues

Adamo, M. L., Raizada, M. K., Shemer, J., Ota, A., Sumners, C., Olson, J. A., & LeRoith, D. (2003) · Humana Press eBooks · doi:10.1385/0-89603-199-3:227