Cited by 467Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on BehaviorDeep Brain Stimulation and Movement Disorders

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Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

Di Chiara, Gaetano, Morelli, Micaela, Consolo, Silvana·1994·Trends in Neurosciences

DOI 10.1016/0166-2236(94)90005-1

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Abstract

The striatum is viewed as a structure performing fast neurotransmitter-mediated operations through somatotopically organized projections to medium-size spiny neurons. This view is contrasted with another view that depicts the striatum as a site of diffuse modulatory influences mediated by cholinergic interneurons and by dopamine and N-methyl-D-aspartate receptors. These two operational and organizational modes both contribute, through their mutual interaction, to the function of basal ganglia. Detailed knowledge of the neural mechanisms by which such interactions take place and are expressed into behaviour, can provide new insight into the physiopathology and new clues for therapy of disorders of basal ganglia.

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Authors: Di Chiara, G., Morelli, M., & Consolo, S.
Affiliations: University of Cagliari (IT)
Mario Negri Institute for Pharmacological Research (IT)
ORCID: Morelli, Micaela
Venue: Trends in Neurosciences
Publisher: Elsevier BV
Published: 1994-06
Volume: 17
Issue: 6
Pages: 228-233
ISSN: 0166-2236 (ISSN-L)
DOI: 10.1016/0166-2236(94)90005-1
OpenAlex: W1990162104
Semantic Scholar: 6620d60a424c6c77bf86292e9bd8b24706c6c57f
Cited by: 467
References: 72
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 11 · 2016: 9 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 13
FWCI: 4.49
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Trends in Neurosciences (publishedVersion)
PubMed (publishedVersion)
UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: striatum, acetylcholine, dopamine, NMDA receptor, cholinergic interneurons, medium spiny neurons, basal ganglia, neurotransmitter interactions, basal ganglia disorders, neuromodulation
MeSH terms: Acetylcholine, Animals, Corpus Striatum, Dopamine, Humans, Synaptic Transmission, Receptors, Dopamine, N-Methylaspartate, Neurotransmitter Agents

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Modulatory functions of neurotransmitters in the striatum: ACh/dopamine/NMDA interactions

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