IAP retrotransposons in the mouse liver as reporters of ageing
Abstract
IAP are endogenous retrovirus-like elements present at a thousand copies in the murine genome. They can modulate the level of expression of the tagged genes into which they have inserted, and conversely their activity could be influenced by the level of activity of the genes and/or DNA sequences into which they are embedded. In this report, we have analysed by Northern blots the pattern of expression of the IAP-related transcripts in the organs of young and ageing mice. We show that IAP transcripts of unexpected size (namely 10 kb and 6 kb) are induced in the liver of ageing mice from all inbred and hybrid strains tested. These transcripts are not detected in young mice, and their intensity disclose variations depending on the strain, as those observed for the two canonical 7.2 and 5.4 kb IAP transcripts. It is suggested that these age-dependent IAP transcripts originate from unique sites within the mouse genome that are 'tagged' by an IAP sequence, which would be sensitive both to strain-dependent cellular factors acting at the level of all IAPs, and to an age-dependent liver-specific cellular factor and/or DNA state, responsible for the position-dependent effect. These age-dependent transcripts should allow the identification of putative genes or factors of 'senescence'.
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Age-associated increases in transposable element activation contributing to genomic instability have been noted in yeast, flies, and mammals.
“studies in yeast, flies and mammals have noted an age-associated increase in the activation of transposable elements, contributing to genomic instability49–51.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [49]
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Self-citation
- Authors
- Dupressoir, A., Puech, A., & Heidmann, T.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 1264
- Issue
- 3
- Pages
- 397-402
- ISSN
- 0167-4781 (ISSN-L)
- OpenAlex
- W2078328707
- Cited by
- 14
- References
- 31
- Citations by year
- 2018: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- aging, mouse liver, inbred mouse strains, hybrid mouse strains, senescence, retrotransposition, gene expression
- MeSH terms
- Aging, Animals, Female, Liver, Male, Mice, Inbred Strains, RNA, Retroelements, Mice
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