The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Glucose-induced changes in cytosolic ATP content in pancreatic islets
Abstract
The cytosolic and mitochondrial contents in ATP, ADP and AMP were measured in islets incubated for 45 min at increasing concentrations of D-glucose and then exposed for 20 s to digitonin. The latter treatment failed to affect the total islet ATP/ADP ratio and adenylate charge. D-Glucose caused a much greater increase in cytosolic than mitochondrial ATP/ADP ratio. In the cytosol, a sigmoidal pattern characterized the changes in ATP/ADP ratio at increasing concentrations of D-glucose. These findings are compatible with the view that cytosolic ATP participates in the coupling of metabolic to ionic events in the process of nutrient-induced insulin release.
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“As intracellular ATP levels never fall below 1 mM in β-cells, even in the absence of glucose (143, 422), KATP channels are largely closed, even at resting glucose concentrations.”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [422]
Citations
Cites
Intracellular ATP directly blocks K+ channels in pancreatic B-cells
Cook, D. L., & Hales, N. (1984) · Nature · doi:10.1038/311271a0 · Cited by 1,208
Stanley, P. E., & Williams, S. G. (1969) · Analytical Biochemistry · doi:10.1016/0003-2697(69)90323-6 · Cited by 907
The stimulus-secretion coupling of glucose-induced insulin release
Malaisse, W. J., Hutton, J. C., Kawazu, S., Herchuelz, A., Valverde, I., & Sener, A. (1979) · Diabetologia · doi:10.1007/bf01223623 · Cited by 426
Self-citationGlucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP
Rorsman, P., & Trube, G. (1985) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00595682 · Cited by 387
Larner, J., Pohl, S. L., & Clarke, W. L. (1984) · Wiley eBooks · Cited by 362
Insulin release: The fuel hypothesis
Malaisse, W. J., Sener, A., Herchuelz, A., & HUTTON, J. C. (1979) · Metabolism · doi:10.1016/0026-0495(79)90111-2 · Cited by 344
Self-citationRapid separation of particulate components and soluble cytoplasm of isolated rat-liver cells
Zuurendonk, P. F., & Tager, J. M. (1974) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(74)90022-x · Cited by 325
Interrelationship of islet metabolism, adenosine triphosphate content and insulin release
Ashcroft, S. J. H., Weerasinghe, L., & Randle, P. J. (1973) · Biochemical Journal · doi:10.1042/bj1320223 · Cited by 301
Wilson, D. F., Stubbs, M., Veech, R. L., Erecińska, M., & Krebs, H. A. (1974) · Biochemical Journal · doi:10.1042/bj1400057 · Cited by 218
(1983) · Analytical Biochemistry · doi:10.1016/0003-2697(83)90635-8 · Cited by 197
Research works printed but not linked: 1
- Malaisse, 1984, Diab. Métab., 9, 313
Cited by
Sorted by citations
Electrophysiology of the pancreatic β-cell
Ashcroft, F. M., & Rorsman, P. (1989) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(89)90013-8 · Cited by 1,122
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793
Imaging cytosolic NADH-NAD(+) redox state with a genetically encoded fluorescent biosensor
Hung, Y. P., Albeck, J. G., Tantama, M., & Yellen, G. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.012 · Cited by 509
“Although metabolic challenges often lead to energy deprivation and decrease in cytosolic ATP:ADP ratio, changes in cytosolic adenine nucleotide pool size are minimal (Schwenke et al., 1981; Malaisse and Sener, 1987) and would not be expected to interfere with Peredox response.”
Eto, K., Tsubamoto, Y., Terauchi, Y., 杉山, 拓., Kishimoto, T. E., Takahashi, N. K., Yamauchi, N., Kubota, N., Murayama, S., Aizawa, T., et al. (1999) · Science · doi:10.1126/science.283.5404.981 · Cited by 492
Wang, Z., & Thurmond, D. C. (2009) · Journal of Cell Science · doi:10.1242/jcs.034355 · Cited by 386
“Intracellular glucose is rapidly metabolized to yield a net increase in the ATP:ADP ratio (Kennedy et al., 1999; Malaisse and Sener, 1987), triggering closure of ATPsensitive K+ channels (KATP) and cell depolarization (Cook and Hales, 1984; Meglasson and Matschinsky, 1986).”
Background
Metadata
- Authors
- Malaisse, W. J., & Sener, A.
- Affiliations
- Université Libre de Bruxelles (BE)
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
- Publisher
- Elsevier BV
- Published
- 1987-02
- Volume
- 927
- Issue
- 2
- Pages
- 190-195
- ISSN
- 0167-4889 (ISSN-L)
- OpenAlex
- W2037863419
- Cited by
- 116
- References
- 29
- Citations by year
- 2023: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2013: 1
- FWCI
- 19.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Funders
- Fondation pour la Recherche Médicale
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Keywords
- glucose, pancreatic islets, cytosolic ATP, ATP/ADP ratio, mitochondrial ATP, digitonin, insulin secretion, energy metabolism
- MeSH terms
- Insulin Secretion, Adenosine Diphosphate, Adenosine Monophosphate, Adenosine Triphosphate, Animals, Cytosol, Digitonin, Glucose, Glutamate Dehydrogenase, Insulin, Ion Channels, Islets of Langerhans, L-Lactate Dehydrogenase, Mitochondria, Potassium, Rats
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