Intracellular ATP directly blocks K+ channels in pancreatic B-cells
Abstract
It is known that glucose-induced depolarization of pancreatic B-cells is due to reduced membrane K+-permeability and is coupled to an increase in the rate of glycolysis, but there has been no direct evidence linking specific metabolic processes or products to the closing of membrane K+ channels. During patch-clamp studies of proton inhibition of Ca2+-activated K+ channels [GK(Ca)] in B-cells, we identified a second K+-selective channel which is rapidly and reversibly inhibited by ATP applied to the cytoplasmic surface of the membrane. This channel is spontaneously active in excised patches and frequently coexists with GK(Ca) channels yet is insensitive to membrane potential and to intracellular free Ca2+ and pH. Blocking of the channel is ATP-specific and appears not to require metabolism of the ATP. This ATP-sensitive K+ channel [GK(ATP)] may be a link between metabolism and membrane K+-permeability in pancreatic B-cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Metabolic regulation of the KATP channel is mediated by changes in intracellular concentrations of ATP and MgADP, which inhibit and stimulate the channel, respectively.
“Metabolic regulation of the channel is mediated by changes in the intracellular concentrations of ATP and MgADP, which inhibit and stimulate the channel, respectively (127, 163, 328).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [127]
In excised inside-out patches, ATP inhibition of KATP channels is half-maximal at ≈10 μM in the absence of Mg2+, but this increases to 20-30 μM in the presence of Mg2+ due to simultaneous Mg-nucleotide stimulation via SUR1.
“In excised inside-out patches, ATP inhibition is half-maximal at ≈10 μM in the absence of Mg2+ (127), but this increases to 20-30 µM in the presence of Mg2+ due to the simultaneous presence of Mg-nucleotide stimulation via SUR1 (234).”
From Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men (2018) · cites this paper as [127]
Cited by
Sorted by citations
Inagaki, N., Gonoi, T., Clement, J. P., Namba, N., Inazawa, J., Gonzalez, G., Aguilar-Bryan, L., Seino, S., & Bryan, J. (1995) · Science · doi:10.1126/science.270.5239.1166 · Cited by 1,709 · see citing works
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,518 · see citing works
“KATP channels are also found in pancreatic -cells (22, 102), skeletal muscle (739, 740), vascular smooth muscle (40, 349, 353, 741), and neurons (24, 25).”
BackgroundDiversity and ubiquity of K channels.
Rudy, B. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90033-4 · Cited by 1,343 · see citing works
Mammalian G Proteins and Their Cell Type Specific Functions
Wettschureck, N., & Offermanns, S. (2005) · Physiological Reviews · doi:10.1152/physrev.00003.2005 · Cited by 1,161 · see citing works
“High glucose levels result in enhanced intracellular glucose metabolism with ATP accumulation and consecutive closure of ATP-sensitive K channels, leading to the opening of voltage-operated Ca(2) channels and Ca(2) -mediated insulin exocytosis (27, 119).”
BackgroundTriggering and amplifying pathways of regulation of insulin secretion by glucose.
Henquin, J. C. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1751 · Cited by 1,201 · see citing works
“The decrease in K conductance results from the closure of ATP-sensitive K channels (KATP channels) (29,30), the K channels that dominate the resting membrane potential.”
BackgroundCalcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone.
Nelson, M., Patlak, J., Worley, J., & Standen, N. (1990) · American Journal of Physiology · doi:10.1152/ajpcell.1990.259.1.c3 · Cited by 1,140 · see citing works
Electrophysiology of the pancreatic β-cell
Ashcroft, F. M., & Rorsman, P. (1989) · Progress in Biophysics and Molecular Biology · doi:10.1016/0079-6107(89)90013-8 · Cited by 1,127 · see citing works
Inagaki, N., Gonoi, T., Iv, J. P. C., Wang, C.-Z., Aguilar-Bryan, L., Bryan, J., & Seino, S. (1996) · Neuron · doi:10.1016/s0896-6273(00)80124-5 · Cited by 974 · see citing works
Pancreatic β-Cell Electrical Activity and Insulin Secretion: Of Mice and Men
Rorsman, P., & Ashcroft, F. M. (2018) · Physiological Reviews · doi:10.1152/physrev.00008.2017 · Cited by 793 · see citing works
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm
Matschinsky, F. (1996) · Diabetes · doi:10.2337/diab.45.2.223 · Cited by 721 · see citing works
“There are at least four targets of an alteration of the ATP mass-action ratio or of Mg-ADP: i ) the adenine nucleotide-sensitive K channel (33,53); 2) the calcium ATPase of the endoplasmic reticulum (56); 3) ATPsensitive and Ca-independent phospholipase, which generates arachidonic acid as a second messenger (57); and…”
BackgroundProperties and functions of ATP-sensitive K-channels.
Ashcroft, S., & Ashcroft, F. (1990) · Cellular Signalling · doi:10.1016/0898-6568(90)90048-f · Cited by 702 · see citing works
Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels
Aguilar‐Bryan, L., & Bryan, J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.2.0361 · Cited by 697 · see citing works
“When a patch containing KATP channels is excised into an ATP-free solution, channels open, as was first described by Noma for cardiac myocytes (31) and by Cook and Hales (30) and Trube and Hescheler (32) for pancreatic b-cells.”
BackgroundMethodPKA-Dependent and PKA-Independent Pathways for cAMP-Regulated Exocytosis
Seino, S., & Shibasaki, T. (2005) · Physiological Reviews · doi:10.1152/physrev.00001.2005 · Cited by 558 · see citing works
The pharmacology of potassium channels and their therapeutic potential.
Cook, N. S. (1988) · TIPS - Trends in Pharmacological Sciences · doi:10.1016/0165-6147(88)90238-6 · Cited by 594
A Novel Sulfonylurea Receptor Forms with BIR (Kir6.2) a Smooth Muscle Type ATP-sensitive K+ Channel
Isomoto, S., Kondo, C., Yamada, M., Matsumoto, S., Higashiguchi, O., Horio, Y., Matsuzawa, Y., & Kurachi, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.40.24321 · Cited by 544 · see citing works
The pharmacology of ATP-sensitive potassium channels.
Edwards, G., & Weston, A. (1993) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.003121 · Cited by 547 · see citing works
Miki, T., Liss, B., Minami, K., Shiuchi, T., Saraya, A., Kashima, Y., Horiuchi, M., Ashcroft, F., Minokoshi, Y., Roeper, J., et al. (2001) · Nature Neuroscience · doi:10.1038/87455 · Cited by 547 · see citing works
Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
Miki, T., Nagashima, K., Tashiro, F., Kotake, K., Yoshitomi, H., Tamamoto, A., Gonoi, T., Iwanaga, T., Miyazaki, J., & Seino, S. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.18.10402 · Cited by 541 · see citing works
Mechanisms controlling pancreatic islet cell function in insulin secretion
Campbell, J. E., & Newgard, C. B. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00317-7 · Cited by 631 · see citing works
The sulphonylurea receptor may be an ATP-sensitive potassium channel.
Sturgess, N., Cook, D., Ashford, M., & Hales, C. (1985) · The Lancet · doi:10.1016/s0140-6736(85)90403-9 · Cited by 535 · see citing works
Self-citationA view of sur/KIR6.X, KATP channels.
Babenko, A. P., Aguilar-Bryan, L., & Bryan, J. (1998) · Annual Review of Physiology · doi:10.1146/annurev.physiol.60.1.667 · Cited by 533 · see citing works
ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies.
Seino, S. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.337 · Cited by 521 · see citing works
Physiological and pathophysiological roles of ATP-sensitive K+ channels
Seino, S., & Miki, T. (2003) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(02)00053-6 · Cited by 506 · see citing works
“pancreatic -cells (Ashcroft et al., 1984; Cook and Hales, 1984; Rorsman and Trube, 1985; Aguilar-Bryan et al., 1995; Inagaki et al., 1995c).”
BackgroundAdenosine triphosphate-sensitive potassium channels in the cardiovascular system.
Nichols, C., & Lederer, W. J. (1991) · American Journal of Physiology · doi:10.1152/ajpheart.1991.261.6.h1675 · Cited by 490 · see citing works
Activation of KATP channels by H2S in rat insulin‐secreting cells and the underlying mechanisms
Yang, W., Yang, G.-D., Jia, X., Wu, L.-Y., & Wang, R. (2005) · Journal of Physiology · doi:10.1113/jphysiol.2005.097642 · Cited by 482 · see citing works
“Both whole-cell and single-channel recordings of KATP channel currents were performed as previously described (Cook & Hales, 1984; Zhao et al. 2001).”
BackgroundMethodThe VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis
Yu, F. H., & Catterall, W. A. (2004) · Science s STKE · doi:10.1126/stke.2532004re15 · Cited by 473 · see citing works
Glucose‐stimulated signaling pathways in biphasic insulin secretion
Straub, S. G., & Sharp, G. W. G. (2002) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.329 · Cited by 419 · see citing works
Effect of Hypoxia on Insulin Secretion by Isolated Rat and Canine Islets of Langerhans
Dionne, K., Colton, C., & Lyarmush, M. (1993) · Diabetes · doi:10.2337/diab.42.1.12 · Cited by 438 · see citing works
“Previous reports have documented the ATP dependence of several of the steps in the exocytotic secretion of hormones (26,32), including transport of secretion vesicles along microtubules (33,34), operation of the secretory vesicle osmotic pump (35,36), glucose-induced depolarization of the p-cell membrane (37,38), and…”
BackgroundATP-sensitive K+ channels and insulin secretion: their role in health and disease
Ashcroft, F., & Gribble, F. (1999) · Diabetologia · doi:10.1007/s001250051247 · Cited by 435 · see citing works
“They were first described in cardiac muscle [40] and then in beta cells [ 15 ] and subsequently have been found in a wide variety of other tissues, including smooth and skeletal muscle, brain neurones, peripheral axons and epithelial cells [10].”
BackgroundVoltage-dependent ATP-sensitive potassium channels of skeletal muscle membrane
Spruce, A., Standen, N., & Stanfield, P. (1985) · Nature · doi:10.1038/316736a0 · Cited by 421 · see citing works
Inagaki, N., Tsuura, Y., Namba, N., Masuda, K., Gonoi, T., Horie, M., Seino, Y., Mizuta, M., & Seino, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.11.5691 · Cited by 419 · see citing works
Weiss, J., & Lamp, S. (1987) · Science · doi:10.1126/science.2443972 · Cited by 401 · see citing works
Glucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP
Rorsman, P., & Trube, G. (1985) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/bf00595682 · Cited by 387 · see citing works
“These values are similar to those found recently by other investigatiors in rat //-cells (Cook and Hales 1984; Ashcroft et al. 1984).”
Wang, Z., & Thurmond, D. C. (2009) · Journal of Cell Science · doi:10.1242/jcs.034355 · Cited by 386 · see citing works
“, 1999; Malaisse and Sener, 1987), triggering closure of ATPsensitive K+ channels (KATP) and cell depolarization (Cook and Hales, 1984; Meglasson and Matschinsky, 1986).”
BackgroundVasopressin V1a and V1b Receptors: From Molecules to Physiological Systems
Koshimizu, T., Nakamura, K., Egashira, N., Hiroyama, M., Nonoguchi, H., & Tanoue, A. (2012) · Physiological Reviews · doi:10.1152/physrev.00035.2011 · Cited by 413 · see citing works
“Also, AVP was previously reported to facilitate the closure of the ATP-sensitive potassium channel, a critical regulator of the plasma membrane potential (97, 324).”
BackgroundObesity-related derangements in metabolic regulation
Muoio, D. M., & Newgard, C. B. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142512 · Cited by 345 · see citing works
Pancreatic β-cell identity, glucose sensing and the control of insulin secretion.
Rutter, G., Pullen, T., Hodson, D., & Martinez-Sánchez, A. (2015) · Biochemical Journal · doi:10.1042/bj20141384 · Cited by 344 · see citing works
Sheppard, D., & Welsh, M. J. (1992) · The Journal of General Physiology · doi:10.1085/jgp.100.4.573 · Cited by 336 · see citing works
ATP-sensitive K+ channels in pancreatic, cardiac, and vascular smooth muscle cells.
Yokoshiki, H., Sunagawa, M., Seki, T., & Sperelakis, N. (1998) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.1998.274.1.c25 · Cited by 331 · see citing works
Lederer, W. J., & Nichols, C. G. (1989) · Journal of Physiology · doi:10.1113/jphysiol.1989.sp017869 · Cited by 328 · see citing works
Effects of hypoxia on rat hippocampal neurones in vitro.
Fujiwara, N., Higashi, H., Shimoji, K., & Yoshimura, M. (1987) · Journal of Physiology · doi:10.1113/jphysiol.1987.sp016447 · Cited by 325 · see citing works
Kennedy, H., Pouli, A. E., Ainscow, E., Jouaville, L. S., Rizzuto, R., & Rutter, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13281 · Cited by 319 · see citing works
Horie, M., Irisawa, H., & Noma, A. (1987) · The Journal of Physiology · doi:10.1113/jphysiol.1987.sp016572 · Cited by 293 · see citing works
Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion.
Bratanova-Tochkova, T. K., Cheng, H.-Y., Daniel, S., Gunawardana, S., Liu, Y.-J., Mulvaney-Musa, J., Schermerhorn, T., Straub, S. G., Yajima, H., & Sharp, G. W. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s83 · Cited by 301 · see citing works
“In 1984, the ATP-sensitive K (KATP) channel was identified (1) and found to be responsible for glucose-induced depolarization of the -cell (2).”
BackgroundMatching coronary blood flow to myocardial oxygen consumption.
Tune, J., Gorman, M. W., & Feigl, E. (2004) · Journal of applied physiology · doi:10.1152/japplphysiol.01345.2003 · Cited by 298 · see citing works
“These channels are present in a variety of tissues including vascular smooth muscle, arterial endothelial cells, cardiac muscle, skeletal muscle, brain, and pancreatic -cells (9, 35, 107, 144, 153, 158, 182).”
BackgroundEmergence of organized bursting in clusters of pancreatic beta-cells by channel sharing
Sherman, A., Rinzel, J., & Keizer, J. (1988) · Biophysical Journal · doi:10.1016/s0006-3495(88)82975-8 · Cited by 291 · see citing works
Metabolic cycling in control of glucose-stimulated insulin secretion.
Jensen, M., Joseph, J., Ronnebaum, S., Burgess, S. C., Sherry, A., & Newgard, C. (2008) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.90604.2008 · Cited by 282 · see citing works
“The KATP channel-dependent mechanism appears to be particularly important in triggering exocytosis of a small number of granules from the readily releasable pool that are responsible for the first, acute phase of insulin release occurring in the first 10 min following glucose stimulation (4, 15, 72).”
BackgroundHani, E., Boutin, P., Durand, E., Inoue, H., Permutt, M., Velho, G., & Froguel, P. (1998) · Diabetologia · doi:10.1007/s001250051098 · Cited by 282 · see citing works
MacDonald, P. E., & Wheeler, M. B. (2003) · Diabetologia · doi:10.1007/s00125-003-1159-8 · Cited by 264 · see citing works
“In the 1980’s, K+ channels that are closed by glucose [11] and ATP [12] were identified in rat beta cells.”
BackgroundSulfonylurea Receptors, Ion Channels, and Fruit Flies
Boyd, A. E. (1988) · Diabetes · doi:10.2337/diab.37.7.847 · Cited by 281 · see citing works
“Because both nucleotides are present in p-cells, the reduction of the efficiency of ATP in inhibiting the sulfonylurea-blockable K channel may explain why the channel is still active at presumed intracellular ATP concentrations that should completely inactivate the channel (5,6,9,10).”
BackgroundThe pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint
Rorsman, P. (1997) · Diabetologia · doi:10.1007/s001250050706 · Cited by 278 · see citing works
“Using the various recording modes of the patchclamp technique it became possible to demonstrate that the glucose-sensitive resting conductance of the beta cell is due to the activity of K + -channels which are inhibited by intracellular ATP (the K-ATP channel) [7–11].”
MethodCellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1
Gromada, J., Holst, J. J., & Rorsman, P. (1998) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050558 · Cited by 254 · see citing works
“A simple model for glucosestimulated insulin secretion is summarised in Fig. 1. The resting membrane potential of the B-cell is principally determined by the adenosine-5′-triphosphate (ATP)-sensitive K + channels (K ATP channels) [ 11 , 18, 73].”
BackgroundGlucose-sensing mechanisms in pancreatic β-cells
Macdonald, P., Joseph, J., & Rorsman, P. (2005) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2005.1762 · Cited by 270 · see citing works
“Ashcroft et al. (1984) and Cook & Hales (1984) demonstrated the existence of KC channels in rat b-cells that were closed by glucose and ATP, respectively.”
BackgroundGlucose‐stimulated insulin secretion: A newer perspective
Komatsu, M., Takei, M., Ishii, H., & Sato, Y. (2013) · Journal of Diabetes Investigation · doi:10.1111/jdi.12094 · Cited by 256 · see citing works
Trussell, L., & Jackson, M. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-10-03306.1987 · Cited by 252 · see citing works
“It is perhaps analogous to the ATP-inhibited potassium current observed in cardiac and pancreatic cells (Cook and Hales, 1984; Kakei et al., 1985).”
BackgroundThe early steps of glucose signalling in yeast.
Gancedo, J. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00117.x · Cited by 249 · see citing works
Kantor, P., Coetzee, W. A., Carmeliet, E., Dennis, S. C., & Opie, L. (1990) · Circulation Research · doi:10.1161/01.res.66.2.478 · Cited by 249 · see citing works
Cardiac ATP-sensitive K+ channels. Evidence for preferential regulation by glycolysis.
Weiss, J. N., & Lamp, S. T. (1989) · The Journal of General Physiology · doi:10.1085/jgp.94.5.911 · Cited by 228 · see citing works
“In this tissue, ATP-sensitive K + channels, which are responsible for the high resting membrane K + conductance of beta cells in the absence of extracellular glucose, are suppressed when glucose concentration is increased, causing membrane depolarization which triggers Ca+ +-mediated spikes and insulin release (Ashcro…”
The ATP‐sensitivity of K<sup>+</sup> channels in rat pancreatic B‐cells is modulated by ADP
Kakei, M., Kelly, R. P., Ashcroft, S. J. H., & Ashcroft, F. M. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)81533-2 · Cited by 241 · see citing works
Modulation of ATP-sensitive K+ channels in skeletal muscle by intracellular protons
Davies, N. W. (1990) · Nature · doi:10.1038/343375a0 · Cited by 240 · see citing works
Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels
Ashford, M., Boden, P., & Treherne, J. M. (2004) · Pflügers Archiv · doi:10.1007/bf00373626 · Cited by 235 · see citing works
Trube, G., Rorsman, P., & Ohno-Shosaku, T. (1986) · Pflügers Archiv · doi:10.1007/bf00657506 · Cited by 231 · see citing works
“Glucose has recently been shown to depolarize pancreatic B-cells by inducing the closure of a K + channel which is regulated by intracellular ATP (Cook and Hales 1984; Ashcroft et al. 1984; Rorsman and Trube 1985: Findlay et al. 1985b).”
Dunne, M. J., & Petersen, O. H. (1986) · FEBS Letters · doi:10.1016/0014-5793(86)81532-0 · Cited by 229 · see citing works
KATPChannels in the Cardiovascular System
Foster, M. N., & Coetzee, W. A. (2015) · Physiological Reviews · doi:10.1152/physrev.00003.2015 · Cited by 222 · see citing works
ATP-Sensitive K+ Channels in Pancreatic β-Cells: Spare-Channel Hypothesis
Cook, D., Satin, L., Ashford, M., & Hales, C. (1988) · Diabetes · doi:10.2337/diab.37.5.495 · Cited by 222 · see citing works
“, in isolated patches (1,8) and cell-attached patches (2,3)].”
BackgroundMethodInfluentialSelf-citationSpruce, A., Standen, N., & Stanfield, P. (1987) · Journal of Physiology · doi:10.1113/jphysiol.1987.sp016364 · Cited by 222 · see citing works
Drain, P., Li, L., & Wang, J. (1998) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.95.23.13953 · Cited by 219 · see citing works
Brat, D. J., Scheithauer, B., Fuller, G., & Tihan, T. (1991) · Annals of the New York Academy of Sciences · doi:10.1111/j.1750-3639.2007.00082.x · Cited by 216
Are Metabolic Oscillations Responsible for Normal Oscillatory Insulin Secretion?
Tornheim, K. (1997) · Diabetes · doi:10.2337/diab.46.9.1375 · Cited by 211 · see citing works
Suzuki, M., Li, R. A., Miki, T., Uemura, H., Sakamoto, N., Ohmoto‐Sekine, Y., Tamagawa, M., Ogura, T., Seino, S., Marbán, E., et al. (2001) · Circulation Research · doi:10.1161/01.res.88.6.570 · Cited by 208 · see citing works
Beta-cell mitochondria in the regulation of insulin secretion: a new culprit in Type II diabetes
Wollheim, C. (2000) · Diabetologia · doi:10.1007/s001250050044 · Cited by 207 · see citing works
“This was first shown in 1984 in excised beta-cell plasma membrane patches [ 34 ] and in glucose-stimulated intact cells [35].”
BackgroundMechanisms of inhibition of insulin release.
Sharp, G. W. (1996) · American Journal of Physiology · doi:10.1152/ajpcell.1996.271.6.c1781 · Cited by 200 · see citing works
Role of potassium channels in cerebral blood vessels.
Kitazono, T., Faraci, F., Taguchi, H., & Heistad, D. (1995) · Stroke · doi:10.1161/01.str.26.9.1713 · Cited by 199 · see citing works
Oscillatory control of insulin secretion
Tengholm, A., & Gylfe, E. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.07.009 · Cited by 188 · see citing works
“However, the discovery that β-cell depolarization with increase of [Ca 2+ ] i depends on ATP (Ashcroft et al., 1984; Cook and Hales, 1984) shifts attention towards oxidative metabolism as most ATP is produced by mitochondria.”
BackgroundThurmond, D., Gonelle-Gispert, C., Furukawa, M., Halban, P., & Pessin, J. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0333 · Cited by 192 · see citing works
Pharmacological Evidence for a Role of ATP‐Dependent Potassium Channels in Myocardial Stunning
Auchampach, J., Maruyama, M., Cavero, I., & Gross, G. (1992) · Circulation · doi:10.1161/01.cir.86.1.311 · Cited by 192
Calcium-independent phospholipases A2 and their roles in biological processes and diseases
Ramanadham, S., Ali, T., Ashley, J. W., Bone, R. N., Hancock, W. D., & Lei, X. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r058701 · Cited by 195 · see citing works
KATP channel openers: Structure‐activity relationships and therapeutic potential
Mannhold, R. (2004) · Medicinal research reviews (Print) · doi:10.1002/med.10060 · Cited by 183
Properties of cloned ATP‐sensitive K+ currents expressed in Xenopus oocytes.
Gribble, F., Ashfield, R., Ammala, C., & Ashcroft, F. M. (1997) · Journal of Physiology · doi:10.1113/jphysiol.1997.sp021843 · Cited by 183 · see citing works
Nutrient–secretion coupling in the pancreatic islet β-cell: recent advances
Rutter, G. A. (2001) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(01)00013-9 · Cited by 179 · see citing works
Sturgess, N., Kozlowski, R., Carrington, C., Hales, C., & Ashford, M. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb16551.x · Cited by 176 · see citing works
Neuronal metabolism governs cortical network response state.
Cunningham, M., Pervouchine, D., Racca, C., Kopell, N., Davies, C., Jones, R. S. G., Traub, R., & Whittington, M. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0600604103 · Cited by 174 · see citing works
Avshalumov, M., & Rice, M. (2003) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1834314100 · Cited by 173 · see citing works
The sulfonylurea controversy: more questions from the heart.
Brady, P., & Terzic, A. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(98)00038-2 · Cited by 168 · see citing works
Pérez-Armendariz, M., Roy, C., Spray, D. C., & Bennett, M. V. (1991) · Biophysical Journal · doi:10.1016/s0006-3495(91)82200-7 · Cited by 165 · see citing works
Kajioka, S., Kitamura, K., & Kuriyama, H. (1991) · Journal of Physiology · doi:10.1113/jphysiol.1991.sp018885 · Cited by 165 · see citing works
Avshalumov, M., Chen, B. T., Koos, T., Tepper, J., & Rice, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4701-04.2005 · Cited by 164 · see citing works
Nevins, A. K., & Thurmond, D. (2003) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00093.2003 · Cited by 162 · see citing works
“This ATP alters the basal ATP/ADP ratio, causing the ATP-sensitive K (KATP) channels to close, depolarizing the cell and leading to the opening of Ca2 channels, overall increasing cytoplasmic Ca2 concentration ([Ca2 ]i) (1, 13, 51, 57).”
BackgroundChen, M.-K., & Simard, J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-17-06512.2001 · Cited by 162 · see citing works
“In contrast, in NRAs, ADP and AMP were completely without effect, and half-maximum block was observed with [ATP]i of 0.8 M.”
BackgroundInfluentialMolecular aspects of ATP-sensitive K+ channels in the cardiovascular system and K+ channel openers.
Fujita, A., & Kurachi, Y. (2000) · Pharmacology and Therapeutics · doi:10.1016/s0163-7258(99)00050-9 · Cited by 162 · see citing works
Kiekens, R., Veld, P. I. '. '., Mahler, T., Schuit, F., van de Winkel, M., & Pipeleers, D. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115551 · Cited by 161 · see citing works
Cura, A. J., & Carruthers, A. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110024 · Cited by 163 · see citing works
Potassium channel openers and vascular smooth muscle relaxation.
Edwards, G., & Weston, A. (1990) · Pharmacology and Therapeutics · doi:10.1016/0163-7258(90)90082-d · Cited by 160 · see citing works
Fujimura, N., Tanaka, E., Yamamoto, S., Shigemori, M., & Higashi, H. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.1.378 · Cited by 159 · see citing works
“The sensitivity of KATP chan- 1989; Cook and Hales 1984; Kakei et al. 1985; Spruce et al. 1987; Trube and Hescheler 1984).”
Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide.
Ueda, K., Komine, J., Matsuo, M., Seino, S., & Amachi, T. (1999) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.96.4.1268 · Cited by 157 · see citing works
Sequence Variants in the Sulfonylurea Receptor (SUR) Gene Are Associated With NIDDM in Caucasians
Inoue, H., Ferrer, J., Welling, C., Elbein, S., Hoffman, M. D., Mayorga, R., Warren-Perry, M., Zhang, Y., Millns, H., Turner, R., et al. (1996) · Diabetes · doi:10.2337/diab.45.6.825 · Cited by 157 · see citing works
“It is now known that signals derived from the metabolism of glucose in pancreatic p-cells lead to a sequence of events that includes closure of ATP-sensitive potassium channels (IKATP); membrane depolarization; activation of voltagegated Ca channels, which results in increased intracellular Ca; and insulin exocytosis…”
BackgroundFranco, E. D., Saint‐Martin, C., Brusgaard, K., Johnson, A. E. K., Aguilar‐Bryan, L., Bowman, P., Arnoux, J., Larsen, A. R., Sanyoura, M., Greeley, S. A. W., et al. (2020) · Human Mutation · doi:10.1002/humu.23995 · Cited by 179 · see citing works
“ATP‐sensitive potassium (KATP) channels were found to couple glucose metabolism to membrane electrical activity and insulin release over 30 years ago (Ashcroft, Harrison, & Ashcroft, 1984; Cook & Hales, 1984; Rorsman & Trube, 1985).”
BackgroundMiyoshi, Y., Wakatsuki, T., Nomura, M., Saito, K., Nakaya, Y., & Inoue, I. (1992) · Japanese Journal of Pharmacology · doi:10.1161/01.res.70.3.612 · Cited by 154
Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells
Kalwat, M. A., & Thurmond, D. C. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.73 · Cited by 158 · see citing works
Mechanisms underlying episodic gonadotropin-releasing hormone secretion.
Moenter, S., DeFazio, A., Pitts, G. R., & Nunemaker, C. S. (2003) · Frontiers in neuroendocrinology (Print) · doi:10.1016/s0091-3022(03)00013-x · Cited by 152 · see citing works
- Authors
- Cook, D. L., & Hales, N.
- Affiliations
- United States Department of Veterans Affairs (US)
- Venue
- Nature
- Published
- 1984-09
- Volume
- 311
- Issue
- 5983
- Pages
- 271-273
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1985770721
- Cited by
- 1,208
- References
- 24
- Citations by year
- 2026: 11 · 2025: 16 · 2024: 12 · 2023: 22 · 2022: 14 · 2021: 21 · 2020: 12 · 2019: 19 · 2018: 13 · 2017: 9 · 2016: 15 · 2015: 21 · 2014: 34 · 2013: 14 · 2012: 29
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- ATP-sensitive potassium channels, pancreatic beta cells, intracellular ATP, potassium channel inhibition, glycolysis, proton inhibition, calcium-activated potassium channels
- MeSH terms
- Adenosine Triphosphate, Animals, Cell Membrane Permeability, Cells, Cultured, Cytoplasm, Electric Conductivity, Ion Channels, Islets of Langerhans, Potassium, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
