Cited by 334Parkinson's Disease Mechanisms and TreatmentsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

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The rat brain synucleins; family of proteins transiently associated with neuronal membrane

Maroteaux, L., Scheller, R.H.·1991·Molecular Brain Research

DOI 10.1016/0169-328x(91)90043-w

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Abstract

The synuclein cDNA was previously cloned from Torpedo califonica using an antiserum against purified synaptic vesicles. Here we show that this gene hybridizes to several clones in a rat brain cDNA library. These clones represent cDNAs coding for different proteins, thus determining a family. These proteins display similar organization to the Torpedo protein. The homology resides within the repetition of 7 amino acids. The diversity is generated by alternative splicing as suggested by Southern analysis, as well as by sequence analysis. These proteins are specifically expressed in the rat brain. In situ hybridization shows expression of synuclein mRNAs in discrete areas of the brain, the hippocampus is the most intensely stained area. This localization is reminiscent of those molecules involved in phosphoinositols second messenger pathways. Synuclein proteins are present in rat brain in dual form--a small form which is soluble and a large form which is associated with synaptosomal membranes in a regulated fashion.

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Authors: Maroteaux, L., & Scheller, R. H.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Maroteaux, L.
ORCID: Maroteaux, L.
Venue: Molecular Brain Research
Publisher: Elsevier BV
Published: 1991-10
Volume: 11
Issue: 3-4
Pages: 335-343
ISSN: 0169-328X (ISSN-L)
DOI: 10.1016/0169-328x(91)90043-w
OpenAlex: W1968390598
Cited by: 334
References: 29
Citations by year: 2026: 3 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 14 · 2019: 15 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 7
FWCI: 0.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: synuclein, alternative splicing, protein families, hippocampus, synaptosomal membranes, brain-specific expression, rat brain, cDNA cloning
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Brain, DNA, Multigene Family, Molecular Sequence Data, Nerve Tissue Proteins, Oligodeoxyribonucleotides, Organ Specificity, Sequence Homology, Nucleic Acid, Torpedo, Blotting, Northern, Restriction Mapping, Gene Library, Rats, Synucleins

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The rat brain synucleins; family of proteins transiently associated with neuronal membrane

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