The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
The rat brain synucleins; family of proteins transiently associated with neuronal membrane
Abstract
The synuclein cDNA was previously cloned from Torpedo califonica using an antiserum against purified synaptic vesicles. Here we show that this gene hybridizes to several clones in a rat brain cDNA library. These clones represent cDNAs coding for different proteins, thus determining a family. These proteins display similar organization to the Torpedo protein. The homology resides within the repetition of 7 amino acids. The diversity is generated by alternative splicing as suggested by Southern analysis, as well as by sequence analysis. These proteins are specifically expressed in the rat brain. In situ hybridization shows expression of synuclein mRNAs in discrete areas of the brain, the hippocampus is the most intensely stained area. This localization is reminiscent of those molecules involved in phosphoinositols second messenger pathways. Synuclein proteins are present in rat brain in dual form--a small form which is soluble and a large form which is associated with synaptosomal membranes in a regulated fashion.
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“αSyn is predominantly expressed within the presynaptic terminals of neurons [141–143]”
From α-synuclein in the pathophysiology of Alzheimer’s disease (2019) · cites this paper as [142]
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Metadata
- Authors
- Maroteaux, L., & Scheller, R. H.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Maroteaux, L.
- ORCID
- Maroteaux, L.
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1991-10
- Volume
- 11
- Issue
- 3-4
- Pages
- 335-343
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W1968390598
- Cited by
- 334
- References
- 29
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 7 · 2022: 12 · 2021: 9 · 2020: 14 · 2019: 15 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 6 · 2014: 6 · 2013: 9 · 2012: 7
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- synuclein, alternative splicing, protein families, hippocampus, synaptosomal membranes, brain-specific expression, rat brain, cDNA cloning
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Brain, DNA, Multigene Family, Molecular Sequence Data, Nerve Tissue Proteins, Oligodeoxyribonucleotides, Organ Specificity, Sequence Homology, Nucleic Acid, Torpedo, Blotting, Northern, Restriction Mapping, Gene Library, Rats, Synucleins
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