The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Abstract
Rat pups 2-14 days of age were exposed daily to handling (15 min of separation from mother and home cage), maternal separation (MS; 180 min of comparable separation), or were left entirely undisturbed (non-handled; NH). As adults, MS rats showed increased hypothalamic corticotropin-releasing factor (CRF) mRNA levels compared with NH rats, while CRF mRNA levels in H rats were significantly lower than either MS or NH animals. Hypothalamic CRF content under basal conditions followed exactly the same pattern. A 20-min period of restraint stress produced significant CRF depletion in all groups, although the percentage of depletion was significantly lower in H animals compared with either MS or NH animals. Restraint stress produced significantly higher increases in plasma corticosterone in MS and NH animals than in H animals. These data reflect the importance of early environmental factors in regulating the development of the hypothalamic CRF system and the responsiveness of the hypothalamic-pituitary-adrenal axis to stress.
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“Short periods of maternal separation, however, can elicit higher rates of licking and grooming from rat mothers, which appears to blunt rises in these HPA products (Plotsky and Meaney, 1993).”
From Quality of maternal and paternal care predicts later stress reactivity in the cooperatively-breeding marmoset (Callithrix geoffroyi) (2013) · cites this paper as Plotsky and Meaney, 1993
In the citing paper
“Repeated and prolonged maternal separation in rodent pups results in exaggerated SNS and HPA-axis responses to stress during adolescence and adulthood (Kalinichev et al., 2002; Plotsky and Meaney, 1993).”
From Developmental psychoneuroendocrine and psychoneuroimmune pathways from childhood adversity to disease (2017) · cites this paper as Plotsky and Meaney, 1993
In the citing paper
“Environmental conditions that increased the frequency of pup LG in the rat are associated with decreased paraventricular CRF expression.66,110-113”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [111]
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Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,515
The Neuroendocrinology of Stress and Aging: The Glucocorticoid Cascade Hypothesis
Sapolsky, R. M., Krey, L. C., & McEwen, B. S. (1986) · Science of Aging Knowledge Environment · doi:10.1126/sageke.2002.38.cp21 · Cited by 2,343
Effect of Neonatal Handling on Age-Related Impairments Associated with the Hippocampus
Meaney, M. J., Aitken, D. H., van Berkel, C., Bhatnagar, S., & Sapolsky, R. M. (1988) · Science · doi:10.1126/science.3340858 · Cited by 1,074
Self-citationSapolsky, R. M., Krey, L. C., & McEwen, B. S. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.19.6174 · Cited by 758
Infantile Experience and Resistance to Physiological Stress
Levine, S. (1957) · Science · doi:10.1126/science.126.3270.405 · Cited by 659
Physiological and behavioral effects of infantile stimulation
Levine, S., Haltmeyer, G. C., Karas, G. G., & Denenberg, V. H. (1967) · Physiology & Behavior · doi:10.1016/0031-9384(67)90011-x · Cited by 553
Krey, L. C., Butler, W. R., & Knobil, E. (1975) · Endocrinology · doi:10.1210/endo-96-5-1073 · Cited by 473
Herman, J. P., Schafer, M., Young, E. A., Thompson, R. C., DOUGLASS, J. O., Akil, H., & Watson, S. J. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03072.1989 · Cited by 467
Meaney, M. J., Aitken, D. H., Viau, V., Sharma, S., & Sarrieau, A. (2008) · Neuroendocrinology · doi:10.1159/000125287 · Cited by 457
Self-citation
Research works printed but not linked: 1
- Shanks, 1992, The effects of endotoxin exposure on hypothalamic-pituitary-adrenal activity in rat pups, Soc. Neurosci. Abst., 18
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Sorted by citations
Child abuse: Adolescent records vs. adult recall
Femina, D. D., Yeager, C. A., & Lewis, D. O. (1990) · Child Abuse & Neglect · doi:10.1016/0145-2134(90)90033-p · Cited by 8,820
Anda, R. F., Felitti, V. J., Bremner, J. D., Walker, J. D., Whitfield, C., Perry, B. D., Dube, S. R., & Giles, W. H. (2006) · European archives of psychiatry and clinical neuroscience · doi:10.1007/s00406-005-0624-4 · Cited by 4,292
“Early stressors cause long-term increases in glucocorticoid responses to stress (Plotsky and Meaney 1993; Ladd 1996) as well as decreased genetic expression of cortisol receptors in the hippocampus and increased genetic expression of corticotrophin-releasing factor in the hypothalamus (HPA) system…”
BackgroundLiu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., Sharma, S., Pearson, D., Plotsky, P. M., & Meaney, M. J. (1997) · Science · doi:10.1126/science.277.5332.1659 · Cited by 3,170
Self-citationHeim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791
Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708
Self-citation
Metadata
- Authors
- Plotsky, P. M., & Meaney, M. J.
- Affiliations
- Salk Institute for Biological Studies (US)
- Douglas Mental Health University Institute (CA)
- Corresponding author
- Meaney, Michael J.
- ORCID
- Meaney, Michael J.
- Venue
- Molecular Brain Research
- Publisher
- Elsevier BV
- Published
- 1993-05
- Volume
- 18
- Issue
- 3
- Pages
- 195-200
- ISSN
- 0169-328X (ISSN-L)
- OpenAlex
- W1984427714
- Cited by
- 1,638
- References
- 34
- Citations by year
- 2026: 26 · 2025: 12 · 2024: 18 · 2023: 21 · 2022: 32 · 2021: 36 · 2020: 40 · 2019: 40 · 2018: 49 · 2017: 47 · 2016: 61 · 2015: 49 · 2014: 83 · 2013: 65 · 2012: 75
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01mh045216-05)
- National Institute of Mental Health (MH45216)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- corticotropin-releasing factor, hypothalamus, maternal separation, early life stress, handling, restraint stress, hypothalamic-pituitary-adrenal axis, corticosterone, median eminence, stress responsiveness, developmental programming
- MeSH terms
- Actins, Aging, Animals, Animals, Newborn, Corticosterone, Corticotropin-Releasing Hormone, Female, Handling, Psychological, Hypothalamus, Maternal Behavior, Median Eminence, Reference Values, Restraint, Physical, RNA, Messenger, Social Isolation, Stress, Psychological, Blotting, Northern, Rats
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