The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Neuropeptide Y chronically injected into the hypothalamus: A powerful neurochemical inducer of hyperphagia and obesity
Abstract
Neuropeptide Y (NPY), a putative neurotransmitter abundant in the brain, has recently been shown to act within the hypothalamus, inducing a powerful eating response and a specific appetite for carbohydrates. In the present study, NPY (235 pmol) injected bilaterally in the paraventricular nucleus three times a day for 10 days caused approximately a two-fold increase in daily food intake, a six-fold increase in the rate of body weight gain and a three-fold increase in the body fat of female rats. Subsequently, the food intake and body weight of these subjects decreased precipitously, reaching control levels 20 days postinjection. These findings, demonstrating that exogenous NPY is capable of overriding mechanisms of satiety and body weight control, suggest that disturbances in NPY function may play a role in some disorders of eating behavior and body weight regulation.
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“neuropeptide Y (NPY) directly affects feeding behavior, metabolism and body composition [37, 38]”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [37]
Citations
Cites
Tatemoto, K., Carlquist, M., & Mutt, V. (1982) · Nature · doi:10.1038/296659a0 · Cited by 2,254
NEUROPEPTIDE Y AND HUMAN PANCREATIC POLYPEPTIDE STIMULATE FEEDING BEHAVIOR IN RATS
Clark, J. T., Kalra, P. S., Crowley, W. R., & Kalra, S. P. (1984) · Endocrinology · doi:10.1210/endo-115-1-427 · Cited by 1,276
Neuropeptide Y Distribution in the Rat Brain
Allen, Y. S., Adrian, T. E., Allen, J. M., Tatemoto, K., Crow, T. J., Bloom, S. R., & Polak, J. M. (1983) · Science · doi:10.1126/science.6136091 · Cited by 1,097
The anatomy of neuropeptide-y-containing neurons in rat brain
Chronwall, B. M., DiMaggio, D. A., Massari, V. J., Pickel, V. M., Ruggiero, D. A., & O’Donohue, T. L. (1985) · Neuroscience · doi:10.1016/0306-4522(85)90260-x · Cited by 1,088
Hypothalamic lesions and adiposity in the rat
Hetherington, A. W., & Ranson, S. W. (1940) · The Anatomical Record · doi:10.1002/ar.1090780203 · Cited by 1,028
Stanley, B. G., & LEIBOWITZ, S. F. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.11.3940 · Cited by 741
Self-citationNeuropeptide Y distribution in human brain
Adrian, T. E., Allen, J. M., Bloom, S. R., Ghatei, M. A., Rossor, M. N., Roberts, G. W., Crow, T. J., Tatemoto, K., & Polak, J. M. (1983) · Nature · doi:10.1038/306584a0 · Cited by 701
Neuroreptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus
Stanley, B. G., & LEIBOWITZ, S. F. (1984) · Life Sciences · doi:10.1016/0024-3205(84)90032-8 · Cited by 665
Self-citationSawchenko, P. E., Swanson, L. W., Grzanna, R., Howe, P. R. C., Bloom, S. R., & Polak, J. M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902410203 · Cited by 663
Paraventricular nucleus: A primary site mediating adrenergic stimulation of feeding and drinking
LEIBOWITZ, S. F. (1978) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(78)90333-7 · Cited by 439
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Research works printed but not linked: 1
- Stanley, 1985, Hyperphagia and obesity induced by neuropeptide Y injected chronically into the paraventricular hypothalamus of the rat, Soc Neurosci Abstr, 11, 36
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Central nervous system control of food intake
Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451
A role for ghrelin in the central regulation of feeding
Nakazato, M., Murakami, N., Date, Y., Kojima, M., Matsuo, H., Kangawa, K., & Matsukura, S. (2001) · Nature · doi:10.1038/35051587 · Cited by 3,443
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398
Identification of targets of leptin action in rat hypothalamus.
Schwartz, M. W., Seeley, R. J., Campfield, L. A., Burn, P., & Baskin, D. G. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118891 · Cited by 1,499
Adipogenesis and Obesity: Rounding Out the Big Picture
Spiegelman, B. M., & Flier, J. S. (1996) · Cell · doi:10.1016/s0092-8674(00)81359-8 · Cited by 1,262
Metadata
- Authors
- Glenn Stanley, B., Kyrkouli, S. E., Lampert, S., & Leibowitz, S. F.
- Affiliations
- Rockefeller University (US)
- ORCID
- Leibowitz, Sarah F.
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 1986-11
- Volume
- 7
- Issue
- 6
- Pages
- 1189-1192
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2033305745
- Cited by
- 849
- References
- 27
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 7 · 2023: 7 · 2022: 3 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 12 · 2017: 9 · 2016: 14 · 2015: 12 · 2014: 26 · 2013: 24 · 2012: 33
- FWCI
- 5.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention (MN 22879)
- U.S. Public Health Service
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- neuropeptide Y, hypothalamus, paraventricular nucleus, hyperphagia, obesity, dietary intake, weight gain, fat mass, satiety, dietary habits, body weight regulation
- MeSH terms
- Adipose Tissue, Animals, Appetite, Feeding and Eating Disorders, Body Weight, Energy Intake, Female, Hyperphagia, Hypothalamus, Neuropeptide Y, Obesity, Rats, Inbred Strains, Rats
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