Obesity and the regulation of energy balance

Positional cloning of the mouse obese gene and its human homologue

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Central nervous system control of food intake

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Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans

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Leptin and the regulation of body weight in mammals

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Obesity as a medical problem

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Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

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Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1

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Ghrelin induces adiposity in rodents

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Role of leptin in the neuroendocrine response to fasting

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Targeted disruption of the melanocortin-4 receptor results in obesity in mice

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Increasing Prevalence of Overweight Among US Adults

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Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235 · see citing works

Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice

Chen, H., Charlat, O., Tartaglia, L. A., Woolf, E. A., Weng, X., Ellis, S. J., Lakey, N. D., Culpepper, J., More, K. J., Breitbart, R. E., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81294-5 · Cited by 2,214 · see citing works

Transcriptional regulation of adipogenesis.Preprint

Rosen, E., Walkey, C., Puigserver, P., & Spiegelman, B. (2000) · Genes & Development · doi:10.1101/gad.14.11.1293 · Cited by 2,180 · see citing works

Leptin Inhibits Bone Formation through a Hypothalamic Relay

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PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,960 · see citing works

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Fan, W., Boston, B. A., Kesterson, R. A., Hruby, V. J., & Cone, R. D. (1997) · Nature · doi:10.1038/385165a0 · Cited by 1,902 · see citing works

Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein

Ollmann, M. M., Wilson, B. D., Yang, Y.-K., Kerns, J. A., Chen, Y., Gantz, I., & Barsh, G. S. (1997) · Science · doi:10.1126/science.278.5335.135 · Cited by 1,881 · see citing works

Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans

Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. E., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,719 · see citing works

Towards a molecular understanding of adaptive thermogenesis

Lowell, B. B., & Spiegelman, B. M. (2000) · Nature · doi:10.1038/35007527 · Cited by 1,630 · see citing works

Leptin

Ahima, R. S., & Flier, J. S. (2000) · Annual Review of Physiology · doi:10.1146/annurev.physiol.62.1.413 · Cited by 1,428 · see citing works

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.

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Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese

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Regulated Intramembrane Proteolysis

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A role for melanin-concentrating hormone in the central regulation of feeding behaviour

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The Leptin Receptor

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The Response to Long-Term Overfeeding in Identical Twins

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Discrepancy between Self-Reported and Actual Caloric Intake and Exercise in Obese Subjects

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Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice

Klaman, L. D., Boss, O., Peroni, O. D., Kim, J. K., Martino, J. L., Zabolotny, J. M., Moghal, N., Lubkin, M., Kim, Y.-B., Sharpe, A. H., et al. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5479-5489.2000 · Cited by 1,235 · see citing works

From Lesions to Leptin

Elmquist, J. K., Elias, C. F., & Saper, C. B. (1999) · Neuron · doi:10.1016/s0896-6273(00)81084-3 · Cited by 1,160 · see citing works

Mice lacking melanin-concentrating hormone are hypophagic and lean

Shimada, M., Tritos, N. A., Lowell, B. B., Flier, J. S., & Maratos–Flier, E. (1998) · Nature · doi:10.1038/25341 · Cited by 1,152 · see citing works

Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

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Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

Lu, D., Willard, D. H., Patel, I. R., Kadwell, S. H., Overton, L. K., Kost, T., Luther, M., Chen, W., Woychik, R. P., Wilkison, W. O., et al. (1994) · Nature · doi:10.1038/371799a0 · Cited by 1,075 · see citing works

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.Preprint

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Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance

Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014 · see citing works

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

Erickson, J. C., Clegg, K. E., & Palmiter, R. D. (1996) · Nature · doi:10.1038/381415a0 · Cited by 1,009 · see citing works

Reduced Food Intake and Body Weight in Mice Treated with Fatty Acid Synthase Inhibitors

Loftus, T. M., Jaworsky, D. E., Frehywot, G. L., Townsend, C. A., Ronnett, G. V., Lane, M. D., & Kuhajda, F. P. (2000) · Science · doi:10.1126/science.288.5475.2379 · Cited by 1,004 · see citing works

Leptin Differentially Regulates NPY and POMC Neurons Projecting to the Lateral Hypothalamic Area

Elias, C. F., Aschkenasi, C., Lee, C., Kelly, J., Ahima, R. S., Bjorbæk, C., Flier, J. S., Saper, C. B., & Elmquist, J. K. (1999) · Neuron · doi:10.1016/s0896-6273(01)80035-0 · Cited by 924 · see citing works

Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat

Smith, S. J., Cases, S., Jensen, D. R., Chen, H. C., Sande, E., Tow, B., Sanan, D. A., Raber, J., Eckel, R. H., & Farese, R. V. (2000) · Nature Genetics · doi:10.1038/75651 · Cited by 895 · see citing works

Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity

El-Haschimi, K., Pierroz, D. D., Hileman, S. M., Bjørbæk, C., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9842 · Cited by 887 · see citing works

Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity

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A nutrient-sensing pathway regulates leptin gene expression in muscle and fat

Wang, J., Liu, R., Hawkins, M. A., Barzilai, N., & Rossetti, L. (1998) · Nature · doi:10.1038/31474 · Cited by 823 · see citing works

Activation of the human mitochondrial transcriptionfactor A gene by nuclear respiratory factors: a potential regulatory linkbetween nuclear and mitochondrial gene expression in organellebiogenesis.

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Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

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Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord

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Molecular characterization of the mouse agouti locus

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Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency

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Attenuation of the Obesity Syndrome of ob/ob Mice by the Loss of Neuropeptide Y

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Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

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Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy

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Insulin selectively increases SREBP-1c mRNA in the livers of rats with streptozotocin-induced diabetes

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Life without white fat: a transgenic mousePreprint

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Genetics of body-weight regulation

Barsh, G. S., Farooqi, I. S., & O’Rahilly, S. (2000) · Nature · doi:10.1038/35007519 · Cited by 775 · see citing works

Diet-induced obese mice develop peripheral, but not central, resistance to leptin.

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A Unique Metalolic Sysdrone Causes Obesity in the Melanocortin-3 Receptor-Deficient Mouse

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Energy metabolism in uncoupling protein 3 gene knockout mice

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ADD1/SREBP1 activates PPARγ through the production of endogenous ligand

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The role of SOCS-3 in leptin signaling and leptin resistance

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Integration of NPY, AGRP, and Melanocortin Signals in the Hypothalamic Paraventricular Nucleus

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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

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Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice

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SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985

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SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling

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Leptin-independent hyperphagia and type 2 diabetes in mice with a mutated serotonin 5-HT2C receptor gene

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IRS-2 pathways integrate female reproduction and energy homeostasis

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A major quantitative trait locus determining serum leptin levels and fat mass is located on human chromosome 2

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Medicinal strategies in the treatment of obesity

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Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

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Overexpression of Agrt leads to obesity in transgenic mice

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Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

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Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3

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Effect of CL-316,243, a thermogenic beta 3-agonist, on energy balance and brown and white adipose tissues in rats

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The Central Melanocortin System and Energy Homeostasis

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The “Thrifty Genotype” in 19981

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Neuropeptide Y in hypothalamic paraventricular nucleus: a center coordinating energy metabolism

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A Tissue-Specific Coactivator of Steroid Receptors, Identified in a Functional Genetic Screen

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Cholecystokinin and satiety: current perspectives.

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Differentiation-Dependent Expression of the Brown Adipocyte Uncoupling Protein Gene: Regulation by Peroxisome Proliferator-Activated Receptor γ

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Liporegulation in Diet-induced Obesity

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Regulating Adipogenesis*

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Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline

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BROWN ADIPOSE TISSUE, β3-ADRENERGIC RECEPTORS, AND OBESITY

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Leptin, nutrition, and the thyroid: the why, the wherefore, and the wiring

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Central leptin modulates behavioral and neural responsivity to CCK

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Modulation of Estrogen Receptor-α Transcriptional Activity by the Coactivator PGC-1

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Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance

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