Alzheimer pathology of patients carrying apoliprotein E ε4 allele
Abstract
A recent report suggested that brains of Alzheimer patients homozygous for APOE epsilon 4 show increased amyloid pathology compared to APOE epsilon 3 homozygotes. We studied APOE allele frequencies in 73 AD patients and 38 controls. We also investigated relation of APOE genotypes to beta/A4 immunopositive plaques, cerebrovascular beta/A4 deposition, neurons expressing paired helical filaments (PHFs), and synaptophysin-like immunopositivity in 22 neuropathologically verified AD patients. We also correlated APOE genotypes of definite AD patients to beta/A4 immunoreactivity in dermal vessel walls detected in lifetime skin biopsy samples. APOE allele epsilon 4 frequency was increased in AD compared to nondemented controls (0.37 vs. 0.11; p = 0.006). The number of beta/A4 immunoreactive plaques, PHFs-containing neurons, the degree of cerebrovascular beta/A4 deposition or synaptophysin-like immunoreactivity did not differ significantly in AD patients with or without epsilon 4. beta/A4 deposition in dermal vessel walls was more frequent in definite AD patients with epsilon 4 (43%) than in patients without epsilon 4 (22%). However, the difference did not reach the statistical significance.
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Several subsequent studies reported conflicting findings on the relationship between plaque density and apoE ε4 allele dose.
“However, several subsequent studies reported conflicting findings (Benjamin et al., 1995; Heinonen et al., 1995; Itoh and Yamada, 1996; Landen et al., 1996b).”
From The role of apolipoprotein E in Alzheimer's disease (2009) · cites this paper as Heinonen et al., 1995
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- Authors
- Heinonen, O.
- Affiliations
- University of Eastern Finland (FI)
- Corresponding author
- Heinonen, O
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 1995-08
- Volume
- 16
- Issue
- 4
- Pages
- 505-513
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2067908285
- Cited by
- 52
- References
- 0
- Citations by year
- 2023: 1 · 2021: 2 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, APOE ε4, APOE genotype, paired helical filaments, synaptophysin, genetic risk factors, neuropathology
- MeSH terms
- Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Analysis of Variance, Apolipoproteins E, Blood Vessels, Brain, Female, Gene Frequency, Genotype, Humans, Male, Neurons, Skin, Synapses, Chi-Square Distribution, Amyloid beta-Peptides, Synaptophysin, Neurofibrillary Tangles, tau Proteins
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