Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins

The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics

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Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

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Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

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<i>TREM2</i> Variants in Alzheimer's Disease

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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Chronic traumatic encephalopathy in athletes: Progressive tauopathy after repetitive head injury

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Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

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Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

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The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

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Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

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CNS synaptogenesis promoted by glia-derived cholesterol

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The role of apolipoprotein E in Alzheimer's disease

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

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Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

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Uber eine eigenartige Erkrankung der Hirnrinde

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Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

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The precursor protein of non-Aβ component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

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Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

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Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

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Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

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Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

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Identification of two distinct synucleins from human brain

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A Clinicopathologic Study of 100 Cases of Parkinson's Disease

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

Yeh, F. L., Wang, Y., Tom, I., Gonzalez, L. C., & Sheng, M. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.015 · Cited by 943 · see citing works

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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Neurovascular mechanisms of Alzheimer's neurodegeneration

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Adult mouse astrocytes degrade amyloid-β in vitro and in situ

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ApoE Promotes the Proteolytic Degradation of Aβ

Jiang, Q., Lee, C. Y. D., Mandrekar, S., Wilkinson, B., Cramer, P., Zelcer, N., Mann, K., Lamb, B., Willson, T. M., Collins, J. L., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.010 · Cited by 876 · see citing works

Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies

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Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition

Bales, K. R., Verina, T., Dodel, R. C., Du, Y., Altstiel, L., Bender, M., Hyslop, P., Johnstone, E. M., Little, S. P., Cummins, D. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1197-263 · Cited by 830 · see citing works

<i>APOE</i> predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging

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LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

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Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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Differential Effects of Apolipoproteins E3 and E4 on Neuronal Growth in Vitro

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Fibrillar amyloid-β burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease

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apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

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Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

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Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E

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Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System

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Microglial Cells Internalize Aggregates of the Alzheimer's Disease Amyloid β-Protein Via a Scavenger Receptor

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P-glycoprotein deficiency at the blood-brain barrier increases amyloid- deposition in an Alzheimer disease mouse model

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Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

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Amyloid β-Protein Assembly and Alzheimer Disease

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Neuropathological and genetic correlates of survival and dementia onset in synucleinopathies: a retrospective analysis

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Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

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Targeted Replacement of the Mouse Apolipoprotein E Gene with the Common Human APOE3 Allele Enhances Diet-induced Hypercholesterolemia and Atherosclerosis

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Comprehensive Research Synopsis and Systematic Meta-Analyses in Parkinson's Disease Genetics: The PDGene Database

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Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

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Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

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ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

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Isoform-specific binding of apolipoprotein E to beta-amyloid.

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ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion

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Neuropathologic substrates of Parkinson disease dementia

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Hepatic uptake of chylomicron remnants

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Apolipoprotein E is essential for amyloid deposition in the <i>APP</i> ^V717F transgenic mouse model of Alzheimer's disease

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Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

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ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition

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Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain

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Cholesterol homeostasis and function in neurons of the central nervous system

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Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro.

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Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide

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Microglia Mediate the Clearance of Soluble Aβ through Fluid Phase Macropinocytosis

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Silver staining of Alzheimer's neurofibrillary changes by means of physical development.

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Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

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Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice

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Neurodegeneration in the Central Nervous System of apoE-Deficient Mice

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<i>In Vivo</i> Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

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Deficiency of ABCA1 Impairs Apolipoprotein E Metabolism in Brain

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Oligomerization and Conformational Change Turn Monomeric β-Amyloid and Tau Proteins Toxic: Their Role in Alzheimer’s Pathogenesis

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Murine Gut Microbiome Association With APOE Alleles

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Key Peptides and Proteins in Alzheimer’s Disease

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Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles

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Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

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Lipid-Binding Proteins in Brain Health and Disease

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The Role of HDL and HDL Mimetic Peptides as Potential Therapeutics for Alzheimer’s Disease

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Toward the Language Oscillogenome

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Recent Progress in Research on Mechanisms of Action of Natural Products against Alzheimer’s Disease: Dietary Plant Polyphenols

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How does apolipoprotein E genotype influence the relationship between physical activity and Alzheimer’s disease risk? A novel integrative model

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Sex and APOE Genotype Alter the Basal and Induced Inflammatory States of Primary Microglia from APOE Targeted Replacement Mice

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