The DOI matches its Crossref record; 31 of the 32 references it cites were found in a registry or an index.
Self-replicating Semliki Forest virus RNA as recombinant vaccine
Abstract
Recombinant RNA based on the Semliki Forest virus (SFV) replicon was used to express the nucleoprotein of influenza virus in mice. Two strategies were employed to deliver the RNA. In the first, recombinant RNA was packaged into infectious suicide SFV particles which were used directly for immunization. The second approach involved injection of in vitro-synthesized RNA directly into the quadriceps muscle. Both approaches resulted in the generation of humoral responses with high antibody titres. Immunization with suicide particles showed that a strong, class I-restricted cytotoxic T-cell response can be obtained using only 100 infectious units. We conclude that the self-replicative recombinant SFV RNA may be quite useful as a nucleic acid vaccine.
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“The idea of using in vitro synthesized saRNA as a preventive vaccine was first proposed by Zhou and colleagues in 1994, using a modified Semliki Forest virus (SFV) replicon to express the nucleoprotein (NP) of the influenza virus.197”
From Advances in COVID-19 mRNA vaccine development (2022) · cites this paper as [197]
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mRNA-based therapeutics--developing a new class of drugs
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SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses
Turner, J. S., O’Halloran, J. A., Kalaidina, E., Kim, W., Schmitz, A. J., Zhou, J. Q., Lei, T., Thapa, M., Chen, R. E., Case, J. B., et al. (2021) · Nature · doi:10.1038/s41586-021-03738-2 · Cited by 831
Advances in mRNA Vaccines for Infectious Diseases
Zhang, C., Maruggi, G., Shan, H., & Li, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00594 · Cited by 696
Advances in COVID-19 mRNA vaccine development
Fang, E., Liu, X., Li, M., Zhang, Z., Song, L., Zhu, B., Wu, X., Liu, J., Zhao, D., & Li, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00950-y · Cited by 601
mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.020 · Cited by 507
Metadata
- Authors
- Zhou, X., Berglund, P., Rhodes, G., Parker, S. E., Jondal, M., & Liljeström, P.
- Affiliations
- Karolinska Institutet (SE)
- Vical (United States) (US)
- Corresponding author
- Liljeström, P
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 12
- Issue
- 16
- Pages
- 1510-1514
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2006168695
- Cited by
- 193
- References
- 32
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 9 · 2023: 17 · 2022: 10 · 2021: 13 · 2020: 8 · 2019: 6 · 2018: 1 · 2017: 3 · 2015: 3 · 2014: 7 · 2013: 5 · 2012: 4
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Vaccine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Keywords
- Semliki Forest virus, nucleic acid vaccines, influenza nucleoprotein, humoral immune response, cytotoxic T lymphocytes, self-replicating RNA
- MeSH terms
- Animals, Mice, Inbred BALB C, RNA, Viral, Semliki forest virus, T-Lymphocytes, Cytotoxic, Transfection, Vaccines, Synthetic, Viral Vaccines, Virus Replication, Mice
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