Cited by 507RNA Interference and Gene DeliveryImmunotherapy and Immune ResponsesSARS-CoV-2 and COVID-19 Research

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

Open access
Maruggi, Giulietta, Zhang, Cuiling, Li, Junwei, Ulmer, Jeffrey B., Yu, Dong·2019·Molecular Therapy

Abstract

In the last two decades, there has been growing interest in mRNA-based technology for the development of prophylactic vaccines against infectious diseases. Technological advancements in RNA biology, chemistry, stability, and delivery systems have accelerated the development of fully synthetic mRNA vaccines. Potent, long-lasting, and safe immune responses observed in animal models, as well as encouraging data from early human clinical trials, make mRNA-based vaccination an attractive alternative to conventional vaccine approaches. Thanks to these data, together with the potential for generic, low-cost manufacturing processes and the completely synthetic nature, the prospects for mRNA vaccines are very promising. In addition, mRNA vaccines have the potential to streamline vaccine discovery and development, and facilitate a rapid response to emerging infectious diseases. In this review, we overview the unique attributes of mRNA vaccine approaches, review the data of mRNA vaccines against infectious diseases, discuss the current challenges, and highlight perspectives about the future of this promising technology.

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Crossref · 10.1016/j.ymthe.2019.01.020

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Authors
Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D.
Affiliations
  • GlaxoSmithKline (United States) (US)
  • Qingdao Agricultural University (CN)
Corresponding author
  • Maruggi, Giulietta
  • Yu, Dong
Venue
Molecular Therapy
Publisher
Elsevier BV
Published
2019-04
Volume
27
Issue
4
Pages
757-772
ISSN
1525-0016 (ISSN-L)
OpenAlex
W2912850482
Cited by
507
References
168
Citations by year
2026: 41 · 2025: 71 · 2024: 78 · 2023: 67 · 2022: 84 · 2021: 111 · 2020: 46 · 2019: 9
FWCI
5.50
Type
journal article
Language
en
Open access
Locations
  • Molecular Therapy (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
mRNA vaccines, synthetic mRNA, prophylactic vaccines, infectious diseases, vaccine delivery systems, mRNA stability, immune response, vaccine production, emerging infectious diseases, vaccine development
MeSH terms
Animals, Communicable Disease Control, Humans, Lipids, RNA, Messenger, Vaccination, Vaccines, Synthetic, Drug Delivery Systems, Cancer Vaccines, Nanoparticles

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