mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
Open accessAbstract
In the last two decades, there has been growing interest in mRNA-based technology for the development of prophylactic vaccines against infectious diseases. Technological advancements in RNA biology, chemistry, stability, and delivery systems have accelerated the development of fully synthetic mRNA vaccines. Potent, long-lasting, and safe immune responses observed in animal models, as well as encouraging data from early human clinical trials, make mRNA-based vaccination an attractive alternative to conventional vaccine approaches. Thanks to these data, together with the potential for generic, low-cost manufacturing processes and the completely synthetic nature, the prospects for mRNA vaccines are very promising. In addition, mRNA vaccines have the potential to streamline vaccine discovery and development, and facilitate a rapid response to emerging infectious diseases. In this review, we overview the unique attributes of mRNA vaccine approaches, review the data of mRNA vaccines against infectious diseases, discuss the current challenges, and highlight perspectives about the future of this promising technology.
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Kimura, T., Leal, J. M., Simpson, A., Warner, N. L., Berube, B. J., Archer, J. F., Park, S., Kurtz, R., Hinkley, T., Nicholes, K., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.06.017 · Cited by 52 · see citing works
Pandey, M., Ojha, D., Bansal, S., Rode, A. B., & Chawla, G. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.101003 · Cited by 23 · see citing works
Incorporation of 5 methylcytidine alleviates innate immune response to self-amplifying RNA vaccine
Komori, M., Morey, A. L., Quiñones-Molina, A. A., Fofana, J., Romero, L., Peters, E., Matsuda, K., Gummuluru, S., Smith, J. F., Akahata, W., et al. (2023) · doi:10.1101/2023.11.01.565056 · Cited by 21 · see citing works
- Authors
- Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D.
- Affiliations
- GlaxoSmithKline (United States) (US)
- Qingdao Agricultural University (CN)
- Corresponding author
- Maruggi, Giulietta
- Yu, Dong
- Venue
- Molecular Therapy
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 27
- Issue
- 4
- Pages
- 757-772
- ISSN
- 1525-0016 (ISSN-L)
- PMC
- PMC6453507
- OpenAlex
- W2912850482
- Cited by
- 507
- References
- 168
- Citations by year
- 2026: 41 · 2025: 71 · 2024: 78 · 2023: 67 · 2022: 84 · 2021: 111 · 2020: 46 · 2019: 9
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Therapy (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- mRNA vaccines, synthetic mRNA, prophylactic vaccines, infectious diseases, vaccine delivery systems, mRNA stability, immune response, vaccine production, emerging infectious diseases, vaccine development
- MeSH terms
- Animals, Communicable Disease Control, Humans, Lipids, RNA, Messenger, Vaccination, Vaccines, Synthetic, Drug Delivery Systems, Cancer Vaccines, Nanoparticles
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