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Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs)
Open accessAbstract
The polycyclic aromatic hydrocarbons (PAHs; also referred to as the polynuclear aromatic hydrocarbons or PNAs) are commonly encountered at hazardous waste sites and are often the focus of site remediation activities. However, toxicity criteria are not available for all the PAHs. In the past, EPA has assessed risks posed by mixtures of PAHs by assuming that all carcinogenic PAHs are as potent as benzo[a]pyrene (B[a]P), one of the most potent PAHs. The available information on the toxicity of the PAHs suggests that most are considerably less potent than B[a]P and therefore, the EPA approach is likely to overestimate risks. Several approaches have been developed to allow the relative potency of the different PAHs to be considered in a site-specific risk assessment. This paper evaluates these approaches and presents a modified version that we feel more accurately reflects the state of knowledge on the relative potency of these compounds.
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Citations
Cited by
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He, T., Lamont, B. B., & Pausas, J. G. (2019) · Biological Reviews · doi:10.1111/brv.12544 · Cited by 623
Akhbarizadeh, R., Dobaradaran, S., Amouei Torkmahalleh, M., Saeedi, R., Aibaghi, R., & Faraji Ghasemi, F. (2021) · Environmental Research · doi:10.1016/j.envres.2020.110339 · Cited by 465
Machala, M., Vondráček, J., Bláha, L., Ciganek, M., & Neča, J. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00240-6 · Cited by 323
Xia, Z., Duan, X., Qiu, W., Liu, D., Wang, B., Tao, S., Jiang, Q., Lu, B., Song, Y., & Hu, X. (2010) · Science of The Total Environment · doi:10.1016/j.scitotenv.2010.08.008 · Cited by 323
Metadata
- Authors
- Nisbet, I. C. T., & LaGoy, P. K.
- Venue
- Regulatory Toxicology and Pharmacology
- Publisher
- Elsevier BV
- Published
- 1992-12
- Volume
- 16
- Issue
- 3
- Pages
- 290-300
- ISSN
- 0273-2300 (ISSN-L)
- OpenAlex
- W1983612873
- Cited by
- 2,826
- References
- 0
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). https://app.cochat.ai/papers/10.1016/0273-2300(92)90009-x
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- Nisbet, I. C. T., & LaGoy, P. K. (1992). Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Regulatory Toxicology and Pharmacology. https://doi.org/10.1016/0273-2300(92)90009-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
