The DOI matches its Crossref record.
A 6-month dietary toxicity study of acidic sodium aluminium phosphate in beagle dogs
Abstract
Sodium aluminium phosphate [NaAl3H14(PO4)8. 4H2O], a leavening acid, was administered to groups of six male and six female beagle dogs at dietary concentrations of 0, 0.3, 1.0 or 3.0% for 6 months. No adverse treatment-related clinical signs were observed. There were no statistically significant differences in mean body weights between test and control groups at any of the weekly determinations. Weekly mean food consumption values of all male treated groups did not differ significantly from those of the control group at any stage of the study. Statistically significant reductions in food consumption occurred sporadically in all treated groups of female dogs. No significant absolute or relative organ-weight differences were found between any of the treated groups and their respective controls. Haematological, blood chemistry and urinalysis data showed no toxicologically significant trends. Histopathological examination revealed no changes considered to be related to treatment. Thus dietary administration of sodium aluminum phosphate for 6 months at concentrations of 3% or lower caused no significant toxicological effects in beagle dogs.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“No alterations in hemoglobin, hematocrit and erythrocyte osmotic fragility were reported in a number of experimental Al exposures (Katz et al., 1984; Gomez et al., 1986; Domingo et al., 1987; Pettersen et al., 1990; Oteiza et al., 1993b; Garbossa et al., 1996 ).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Katz et al., 1984
In the citing paper
“Organ weight and histological changes were not observed in the hearts of dogs that consumed 75 mg Al/kg/day (Katz et al., 1984) or 88 mg Al/kg/day (Pettersen et al., 1990) as sodium Al phosphate in the diet for 6 months.”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Katz et al., 1984
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 2
- Campbell, 1957, Aluminum in the environment of man: a review of its hygienic status, A.M.A. Archs ind. Hlth, 15, 359
- Environmental Protection Agency, 1978, Proposed guidelines for registering pesticides in the U.S.; hazard evaluation: humans and domestic animals, Federal Register, 43, 37364
Cited by
Sorted by citations
Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
“Similarly, no effect on organ weight nor histological changes were found in the hearts of rats that ingested 133 or 284 mg Al/kg/day as Al nitrate in drinking water or base diet for 30 days (Gomez et al., 1986) or 100 days, respectively (Domingo et al., 1987).”
BackgroundMethodInfluential
Metadata
- Authors
- Katz, A. C., Frank, D. W., Sauerhoff, M. W., Zwicker, G. M., & Freudenthal, R. I.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 1984-01
- Volume
- 22
- Issue
- 1
- Pages
- 7-9
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2012073860
- Cited by
- 20
- References
- 0
- Citations by year
- 2023: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2013: 1 · 2012: 3
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Agricultural safety and regulations
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- dietary toxicity, beagle dogs, long-term dietary exposure, food additive safety, organ weight, dietary intake, histopathology
- MeSH terms
- Aluminum, Animals, Body Weight, Diet, Dogs, Feeding Behavior, Female, Food Additives, Male, Phosphates, Sodium, Aluminum Compounds, Sodium Compounds
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A 6-month dietary toxicity study of acidic sodium aluminium phosphate in beagle dogs. https://app.cochat.ai/papers/10.1016/0278-6915(84)90045-0
- The paper
- Katz, A. C., Frank, D. W., Sauerhoff, M. W., Zwicker, G. M., & Freudenthal, R. I. (1984). A 6-month dietary toxicity study of acidic sodium aluminium phosphate in beagle dogs. Food and Chemical Toxicology. https://doi.org/10.1016/0278-6915(84)90045-0
