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Cited by 73

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Inhibitory effects of flavourings on mutagenesis induced by chemicals in bacteria

Ohta, T., Watanabe, M., Watanabe, K., Shirasu, Y., Kada, T.·1986·Food and Chemical Toxicology
DOI 10.1016/0278-6915(86)90264-4
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Abstract

The antimutagenic potential of twenty-five flavourings was tested against the activity of several kinds of chemical mutagens in Escherichia coli and Salmonella typhimurium. Anisaldehyde, ethylvanillin and vanillin showed marked antimutagenic effects on mutagenesis induced by 4-nitroquinoline 1-oxide, furylfuramide (AF-2), captan or methylglyoxal in E. coli WP2s. However, they were not effective against mutations provoked by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in S. typhimurium TA98. Despite the decrease in the number of mutants, a remarkable increase was observed in the survival of mutagen-treated WP2s cells after exposure to these flavourings. We assume that these compounds may act as bio-antimutagens by enhancing an error-free recombinational repair system, because this reactivation of survival was strictly dependent on the recA gene function but not on the lexA and uvrA gene functions.

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Research works printed but not linked: 15

  1. Ames, 1975, Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test, Mutation Res., 31, 347, 10.1016/0165-1161(75)90046-1 · DOI
  2. Arimoto, 1980, Inhibition of the mutagenicity of amino acid pyrolysis products by hemin and other biological pyrrole pigments, Biochem. biophys. Res. Commun., 92, 662, 10.1016/0006-291X(80)90384-8 · DOI
  3. Gottesman, 1981, Genetic control of the SOS system in, Cell, 23, 1, 10.1016/0092-8674(81)90261-0 · DOI
  4. Kada, 1981, Antimutagenic activities of human placental extract on ultraviolet light- and gamma-ray-induced mutation in Escherichia coli WP2 B/r trp., J. Radiat. Res., 22, 297, 10.1269/jrr.22.297 · DOI
  5. Kada, 1984, Antimutagenic effects of germanium oxide on Trp-P-2-induced frameshift mutations in Salmonella typhimurium TA98 and TA1538, Mutation Res., 125, 145, 10.1016/0027-5107(84)90066-6 · DOI
  6. Kakinuma, 1984, Cinnamaldehyde: Identification of an antimutagen from a crude drug, cinnamoni cortex, Agric. biol. Chem., 48, 1905
  7. Kakinuma, 1984, Antimutagenic diterpenoids from a crude drug isodonis herba (enmei-so), Agric. biol. Chem., 48, 1647
  8. Kasai, 1982, Mutagenicity of methylglyoxal in coffee, Gann, 73, 681
  9. Little, 1982, The SOS regulatory system of Escherichia coli, Cell, 29, 11, 10.1016/0092-8674(82)90085-X · DOI
  10. Minakata, 1983, Protoanemonin, an antimutagen isolated from plants, Mutation Res., 116, 317, 10.1016/0165-1218(83)90069-1 · DOI
  11. Ohta, 1984, The SOS-function-inducing activity of chemical mutagens in Escherichia coli, Mutation Res., 131, 101, 10.1016/0167-8817(84)90048-8 · DOI
  12. Ohta, 1983, Antimutagenic effects of cinnamaldehyde on chemical mutagenesis in Escherichia coli, Mutation Res., 107, 219, 10.1016/0027-5107(83)90164-1 · DOI
  13. Ohta, 1983, Antimutagenic effects of coumarin and umbelliferone on mutagenesis induced by 4-nitroquinoline 1-oxide or UV irradiation in E. coli, Mutation Res., 117, 135, 10.1016/0165-1218(83)90160-X · DOI
  14. Ohta, 1983, Analysis of the antimutagenic effect of cinnamaldehyde on chemically induced mutagenesis in Escherichia coli, Molec. gen. Genet., 192, 309, 10.1007/BF00392167 · DOI
  15. Witkin, 1976, Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli, Bact. Rev., 40, 869, 10.1128/br.40.4.869-907.1976 · DOI

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Metadata

Authors
Ohta, T., Watanabe, M., Watanabe, K., Shirasu, Y., & Kada, T.
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
1986-01
Volume
24
Issue
1
Pages
51-54
ISSN
0278-6915
DOI
10.1016/0278-6915(86)90264-4
Cited by
73
References
0
Language
en
Licence
Funders
  • Ministerie van Onderwijs, Cultuur en Wetenschap
  • Ministry of Health, Labour and Welfare

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CoChat. (2026). Citation check: Inhibitory effects of flavourings on mutagenesis induced by chemicals in bacteria. https://app.cochat.ai/papers/10.1016/0278-6915(86)90264-4
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Ohta, T., Watanabe, M., Watanabe, K., Shirasu, Y., & Kada, T. (1986). Inhibitory effects of flavourings on mutagenesis induced by chemicals in bacteria. Food and Chemical Toxicology. https://doi.org/10.1016/0278-6915(86)90264-4

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.