The DOI matches its Crossref record.
Neurotoxic effect of enteral aluminium
Abstract
Long Evans rats were treated for 90 days with water-soluble, insoluble or chelated aluminium compounds. The daily treatments given were as follows: controls, NaCl (100 mg/kg body weight) plus citric acid (30 mg/kg); AlCl3 (30 or 100 mg/kg); Al(OH)3 (100 mg/kg) plus citric acid (30 mg/kg); Al(OH)3 (300 mg/kg). Their learning ability was determined in the labyrinth test at day 90, and the choline-acetyltransferase, acetylcholinesterase activity and aluminium content of the brains were measured. Soluble and chelated aluminium compounds seriously worsened the learning ability, and the aluminium content of the brain was elevated. Acetylcholinesterase activity increased and choline-acetyltransferase activity decreased, resulting in a diminished cholinergic activity, which is a characteristic of Alzheimer's disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Rats orally administered Al (100 mg/kg/day) for 90 days accumulated more Al in their brains, had increased brain acetyl cholinesterase activity and had decreased brain choline acetyltransferase activity (Bilkei-Gorzó, 1993).”
From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Bilkei-Gorzó, 1993
Citations
Cites
Still being checked.
Research works printed but not linked: 22
- Connor, 1988, Chronic, oral aluminium administration to rats: cognition and cholinergic parameters, Pharmacology, Biochemistry and Behavior, 31, 467, 10.1016/0091-3057(88)90375-9 · DOI
- Cutrufo, 1984, Experimental aluminium encephalopathy: quantitative EEG analysis of aluminium bioavailability, Journal of Neurology, Neurosurgery, and Psychiatry, 47, 204, 10.1136/jnnp.47.2.204 · DOI
- Ellman, 1961, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochemical Pharmacology, 7, 88, 10.1016/0006-2952(61)90145-9 · DOI
- Eryurek, 1990, Gamma-glutamyl transpeptidase and acetylcholin-esterase activities in brain capillaries of cholesterol-fed rabbits, Research Communications in Chemical Pathology and Pharmacology, 69, 245
- Graves, 1990, The association between aluminium-containing products and Alzheimer's disease, Journal of Clinical Epidemiology, 43, 35, 10.1016/0895-4356(90)90053-R · DOI
- Hersch, 1977, Re-evaluation of the kinetic mechanism of the choline acetyltransferase reaction, Journal of Biological Chemistry, 25, 4796, 10.1016/S0021-9258(17)40126-8 · DOI
- Hetnarski, 1980, Central cholinergic activity in aluminium-induced neurofibrillary degeneration, Annals of Neurology, 7, 489, 10.1002/ana.410070517 · DOI
- Hewitt, 1988, Risk of simultaneous therapy with oral aluminium and citrate compounds, Lancet, 8615, 849, 10.1016/S0140-6736(88)92809-7 · DOI
- Hosovski, 1990, Mental abilities of workers exposed to aluminium, Medicina del Lavoro, 81, 119
- King, 1983, Aluminium, choline transportation and Alzheimer's disease, Medical Journal of Australia, Oct. 1983, 607
- Lipman, 1988, Aluminium induced encephalopathy in the rat, Life Sciences, 42, 863, 10.1016/0024-3205(88)90385-2 · DOI
- Lowry, 1951, Protein measurement with the Folin reagent, Journal of Biological Chemistry, 193, 265, 10.1016/S0021-9258(19)52451-6 · DOI
- McDermott, 1978, Brain-aluminium concentration in dialysis encephalopathy, Lancet, 8070, 901, 10.1016/S0140-6736(78)90681-5 · DOI
- Marquis, 1984, Aluminium activation and inactivation of bovine caudate acetylcholinesterase, Bulletin of Environmental Contamination and Toxicology, 32, 704, 10.1007/BF01607560 · DOI
- Martyn, 1989, Geographical relation between Alzheimer's disease and aluminium in drinking water, Lancet, 8629, 52
- Miller, 1974, Effects of aluminium salts on cultured neuroblastoma cells, Journal of Neurochemistry, 22, 751, 10.1111/j.1471-4159.1974.tb04290.x · DOI
- Perl, 1980, Alzheimer's disease: X-ray spectrometric evidence of aluminium accumulation in neurofibrillary tangle-bearing neurons, Science, 208, 297, 10.1126/science.7367858 · DOI
- Perl, 1982, Intraneuronal aluminium accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam, Science, 217, 1052, 10.1126/science.7112111 · DOI
- Petit, 1980, Neurofibrillary degeneration, dendritic dying back, and learning-memory deficits after aluminium administration: implications for brain aging, Experimental Neurology, 67, 152, 10.1016/0014-4886(80)90166-1 · DOI
- Petrali, 1991, Effect of an anticholinesterase compound on the ultrastructure and function of the rat blood-brain barrier: a review and experiment, Journal of Submicroscopic Cytology and Pathology, 23, 331
- Rabe, 1982, Learning deficit in immature rabbits with aluminium-induced neurofibrillary changes, Experimental Neurology, 76, 441, 10.1016/0014-4886(82)90220-5 · DOI
- Szerdahelyi, 1988, Intraventricular administration of the cholinotoxin AF64A increases the accumulation of aluminium in the rat parietal cortex and hippocampus, but not in the frontal cortex, Brain Research, 444, 356, 10.1016/0006-8993(88)90946-8 · DOI
Cited by
Sorted by citations
Human Health Risk Assessment for Aluminium, Aluminium Oxide, and Aluminium Hydroxide
Krewski, D., Yokel, R. A., Nieboer, E., Borchelt, D., Cohen, J., Harry, J., Kacew, S., Lindsay, J., Mahfouz, A. M., & Rondeau, V. (2007) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400701597766 · Cited by 998
Aluminium toxicosis: a review of toxic actions and effects
Igbokwe, I. O., Igwenagu, E., & Igbokwe, N. A. (2019) · Interdisciplinary Toxicology · doi:10.2478/intox-2019-0007 · Cited by 395
Metadata
- Authors
- Bilkei-Gorzó, A.
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 1993-05
- Volume
- 31
- Issue
- 5
- Pages
- 357-361
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2120649643
- Cited by
- 84
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 7
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- aluminum neurotoxicity, aluminum chloride, aluminum hydroxide, learning disabilities, choline acetyltransferase, acetylcholinesterase, cholinergic activity, Alzheimer's disease model, Long-Evans rats
- MeSH terms
- Aluminum Chloride, Acetylcholinesterase, Administration, Oral, Aluminum, Aluminum Hydroxide, Animals, Brain, Chelating Agents, Chlorides, Choline O-Acetyltransferase, Female, Male, Motor Activity, Solubility, Aluminum Compounds, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
