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Cited by 36RNA and protein synthesis mechanismsRNA modifications and cancerBacterial Genetics and Biotechnology

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Binding sites of the antibiotics pactamycin and celesticetin on ribosomal RNAs

Egebjerg, J., Garrett, R.A.·1991·Biochimie
DOI 10.1016/0300-9084(91)90158-w
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Abstract

The binding sites of the antibiotics pactamycin and celesticetin on the rRNAs of Escherichia coli ribosomes were investigated by a chemical footprinting procedure. Pactamycin protected residues G-693 and C-795 in 16S RNA which are located in an important functional region of the 30S subunit participating in initiation complex formation and ribosomal subunit interaction. Celesticetin altered the reactivities of 5 residues A-2058, A-2059, A-2062, A-2451 and G-2505 within the central loop of domain V of 23S RNA which has been implicated in peptidyltransferase activity. Inferences are drawn concerning the mode of action of the antibiotics.

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Research works printed but not linked: 24

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Cited by

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Metadata

Authors
Egebjerg, J., & Garrett, R. A.
Affiliations
  • Aarhus University (DK)
  • University of Copenhagen (DK)
Corresponding author
Garrett, R.A.
ORCID
Garrett, R.A.
Venue
Biochimie
Publisher
Elsevier BV
Published
1991-07
Volume
73
Issue
7-8
Pages
1145-1149
ISSN
  • 0037-9042 (ISSN-L)
  • 0300-9084
DOI
10.1016/0300-9084(91)90158-w
OpenAlex
W2088791227
Cited by
36
References
0
Citations by year
2022: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 1 · 2013: 1
FWCI
0.52
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biochimie (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
Funders
  • Aarhus Universitet
  • Sundhed og Sygdom, Det Frie Forskningsråd
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA modifications and cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
pactamycin, antibiotic binding sites, ribosomal RNA, Escherichia coli ribosome, 16S rRNA, 23S rRNA, 30S subunit, 50S subunit, peptidyl transferase, initiation complex formation, antibiotic mechanism of action, chemical footprinting
MeSH terms
Anti-Bacterial Agents, Base Sequence, Binding Sites, Escherichia coli, Lincomycin, Molecular Sequence Data, Nucleic Acid Conformation, Pactamycin, RNA, Bacterial, RNA, Ribosomal, RNA, Ribosomal, 16S, RNA, Ribosomal, 23S, Lincosamides

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CoChat. (2026). Citation check: Binding sites of the antibiotics pactamycin and celesticetin on ribosomal RNAs. https://app.cochat.ai/papers/10.1016/0300-9084(91)90158-w
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Egebjerg, J., & Garrett, R. A. (1991). Binding sites of the antibiotics pactamycin and celesticetin on ribosomal RNAs. Biochimie. https://doi.org/10.1016/0300-9084(91)90158-w