Effect of 3,3′-diiodothyronine and 3,5-diiodothyronine on rat liver oxidative capacity
Abstract
We report that 3,5,3'-triiodothyronine (T3) as well as two other iodothyronines (3,3'-diiodothyronine and 3,5-diiodothyronine (T2s)) stimulate rat liver oxidative capacity (measured as cytochrome oxidase activity (COX)). In hypothyroid rats COX activity and mitochondrial protein content are significantly lower than in normal control animals. The administration of both T3 and T2s to hypothyroid rats significantly enhances hepatic COX activity with T3 having the greatest effect (+60%); moreover, T3 restores the mitochondrial protein content whereas the T2s are ineffective. Administration of T2s results in a faster stimulation (already significant 1 h after the injection) of hepatic COX activity than T3 injection. Our results suggest that T3 acts on the protein synthesis mechanism involved in the regulation of the mitochondrial mass while T2s would act directly at the mitochondrial level.
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3,5-T2 increases the rate of oxygen consumption in perfused rat liver, blood mononuclear cells, and rat liver mitochondria.
“Compound 3,5-T2 by itself increases the rate of oxygen consumption in perfused rat liver (Horst et al. 1989), blood mononuclear cells (Kvetny 1992), and rat liver mitochondria (Lanni et al. 1992, 1993, O'Reilly & Murphy 1992)”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Lanni et al. 1992
3,5-T2 affects the activity of enzymes involved in energy metabolism.
“and affects the activity of enzymes involved in energy metabolism, including α-glycerophosphate dehydrogenase (Lombardi et al. 2000), cytochrome oxidase (Lanni et al. 1992, 1993, Goglia et al. 1994, Arnold et al. 1998), malate dehydrogenase (Ball et al. 1997, Lombardi et al. 2000), glucose-6-phosphate dehydrogenase (Lombardi et al. 2000), and F0F1-ATP synthase (Mangiullo et al. 2010).”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Lanni et al. 1992
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928 · see citing works
Padron, A. S., Neto, R. A. L., Pantaleão, T. U., de Souza dos Santos, M. C., Araujo, R. L., de Andrade, B. M., da Silva Leandro, M., de Castro, J. P. S. W., Ferreira, A. C. F., & de Carvalho, D. P. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0502 · Cited by 69 · see citing works
Thyroxine Therapy in Euthyroid Patients Does Not Affect Body Composition or Muscular Function
Dubois, S., Abraham, P., Rohmer, V., Rodien, P., Audran, M., Dumas, J.-F., & Ritz, P. (2008) · Thyroid · doi:10.1089/thy.2007.0037 · Cited by 24 · see citing works
- Authors
- Lanni, A., Moreno, M., Cioffi, M., & Goglia, F.
- Affiliations
- University of Naples Federico II (IT)
- Corresponding author
- Goglia, F.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 1992-08
- Volume
- 86
- Issue
- 3
- Pages
- 143-148
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2043244692
- Cited by
- 57
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 1 · 2014: 10 · 2013: 3 · 2012: 1
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- triiodothyronine, 3,3'-diiodothyronine, 3,5-diiodothyronine, iodothyronines, cytochrome oxidase activity, mitochondrial protein content, hypothyroidism, rat liver
- MeSH terms
- Animals, Electron Transport Complex IV, Diiodothyronines, Iodide Peroxidase, Liver, Male, Mitochondria, Liver, Oxygen Consumption, Propylthiouracil, Rats, Inbred Strains, Rats
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