Thyroxine Therapy in Euthyroid Patients Does Not Affect Body Composition or Muscular Function
Abstract
OBJECTIVE: The main objective of the study was to evaluate the effects of small increments in thyroxine (T4) levels following levothyroxine (L-T4) administration on the body composition of women patients. The secondary objective was to assess the effect of the therapy on energy expenditure and muscular function. METHODS: The prospective, randomized study consisted of a 12-month follow-up of 37 women with thyroid nodules. The patients were divided into two groups for comparison, one treated with L-T4 (20 women) and the other untreated (17 women). L-T4 dose was individually adjusted to obtain a serum thyroid-stimulating hormone in the lower portion of the normal range. Multiple tests, including bioelectrical impedance analysis, dual-energy X-ray absorptiometry, air displacement plethysmography, measurement of waist circumference, and skinfold anthropometry, were used to investigate the muscular, fat, and water compartments; energy expenditure and muscular function were assessed by cycle ergometry. RESULTS: There were no significant differences in body composition, heart rate, energy metabolism, or muscular function between the group of women treated with L-T4 and the untreated group. CONCLUSION: The controlled increase of circulating T4 does not appear to modify the body composition or muscular function in women patients.
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None of the prior long-term LT4 suppression studies investigated other components of energy balance, including food intake, physical activity, or the thermic effect of food.
“None investigated other components of energy balance, including food intake, physical activity, or the thermic effect of food (TEF).”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [11]
Only a handful of studies have reported the metabolic effects of long-term LT4 suppression therapy.
“Only a handful of studies have reported the metabolic effects of long-term LT4 suppression therapy (8-12).”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [11]
Prior long-term LT4 suppression studies did not find significant changes in resting energy expenditure, but some demonstrated effects on body weight or composition.
“While significant changes in resting energy expenditure (REE) were not found, some did demonstrate effects on body weight or composition.”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [11]
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“A study employing 12 months of TSH suppression therapy in euthyroid patients with thyroid nodules did not detect any changes in parameters such as weight, fat mass, waist circumference, and exercise performance compared with patients untreated with LT4, suggesting that LT4 also does not alter body composition or muscl…”
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- Authors
- Dubois, S., Abraham, P., Rohmer, V., Rodien, P., Audran, M., Dumas, J.-F., & Ritz, P.
- Affiliations
- Pôle de maladies métaboliques et médecine interne; Centre Hospitalier Universitaire d'Angers, Angers Cedex 01, France.
- Centre Hospitalier Universitaire d'Angers (FR)
- Inserm (FR)
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2008-01
- Volume
- 18
- Issue
- 1
- Pages
- 13-19
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2065613499
- Cited by
- 24
- References
- 53
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1 · 2012: 3
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Thyroid (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- levothyroxine, thyroxine, euthyroid patients, thyroid nodules, body composition, muscle function, energy expenditure, thyroid-stimulating hormone, women
- MeSH terms
- Adult, Body Composition, Energy Metabolism, Exercise Test, Female, Follow-Up Studies, Heart Rate, Humans, Middle Aged, Prospective Studies, Thyroxine, Thyroid Nodule, Muscle, Skeletal
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